A5005896564- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Robotic Locomotion and Control
- Vestibular and auditory disorders
- Diet and metabolism studies
- Digestive system and related health
- Hydrology and Watershed Management Studies
- Urinary Bladder and Prostate Research
- Robotic Path Planning Algorithms
- Ophthalmology and Eye Disorders
- RNA Research and Splicing
- Hydrology and Drought Analysis
- Smart Agriculture and AI
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Flood Risk Assessment and Management
- Robotics and Automated Systems
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Colorectal and Anal Carcinomas
- Neuroscience of respiration and sleep
- Climate variability and models
Catholic University of Korea
2015-2025
Wonkwang University
2014-2024
Carnegie Mellon University
2023-2024
Korea University
2022-2024
Konkuk University
2005-2024
University of Nevada, Reno
2015-2022
Philadelphia College of Osteopathic Medicine
2022
New York University
2022
Korea Advanced Institute of Science and Technology
2019-2021
Seoul National University
2016-2020
Transcriptome-scale data can reveal essential clues into understanding the underlying molecular mechanisms behind specific cellular functions and biological processes. Transcriptomics is a continually growing field of research utilized in biomarker discovery. The transcriptomic profile interstitial cells Cajal (ICC), which serve as slow-wave electrical pacemakers for gastrointestinal (GI) smooth muscle, has yet to be uncovered. Using copGFP-labeled ICC mice flow cytometry, we isolated...
Genome-scale expression data on the absolute numbers of gene isoforms offers essential clues in cellular functions and biological processes. Smooth muscle cells (SMCs) perform a unique contractile function through specific genes controlled by serum response factor (SRF), transcription that binds to DNA sites known as CArG boxes. To identify SRF-regulated specifically expressed SMCs, we isolated SMC populations from mouse small intestine colon, obtained their transcriptomes, constructed an...
To evaluate the bonding time, shear bond strength (SBS), and adhesive residue index (ARI) of APC(TM) Flash-Free system.Thirty-six extracted human maxillary premolars were randomly divided into three groups (12 per group) used for this in vitro study: group 1, APC Adhesive Coated Appliance System; 2, Clarity ADVANCED Ceramic Bracket pasted manually; 3 (control group), 3M PLUS prepasted brackets bonded with extruded flash removed. Bonding time was measured using a stopwatch. Bond an Instron at...
Platelet-derived growth factor receptor alpha (PDGFRα)+ cells are distributed into distinct morphological groups within the serosal, muscular, and submucosal layers as well myenteric deep muscular plexi. PDGFRα+ directly interact with interstitial of Cajal (ICC) smooth muscle (SMC) in gastrointestinal tissue. These three cell types, SMC, ICC, (SIP cells), form an electrical syncytium, which dynamically regulates motility. We have previously reported transcriptomes SMC ICC. To complete SIP...
Gender and biological sex have distinct impacts on the pathogenesis of type 2 diabetes (T2D). Estrogen deficiency is known to predispose female mice T2D. In our previous study, we found that a high-fat, high-sucrose diet (HFHSD) induces T2D in male through miR-10b-5p/KLF11/KIT pathway, but not females, highlighting hormonal disparities susceptibility. However, underlying molecular mechanisms this protection females remain elusive. To address knowledge gap, utilized ovariectomized,...
Abstract Introduction: Gastric cancer (GC) has high mortality and limited treatment options, with histomorphological features predicting outcomes response. Stricter criteria for undifferentiated GC in Japanese guidelines underscore its poor prognosis. This study developed a deep learning (DL) model to classify as differentiated or undifferentiated, reducing diagnostic variability. The revealed genetic differences aligned distinct from pathologist classifications, providing precise spatial...
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Gender and biological sex have distinct impacts on the pathogenesis of type 2 diabetes (T2D). Estrogen deficiency is known to predispose female mice T2D. In our previous study, we found that high-fat, high-sucrose diet (HFHSD) induces T2D in male through miR-10b-5p/KLF11/KIT pathway, but not females, highlighting hormonal disparities susceptibility. However, underlying molecular mechanisms this protection females remain elusive. To address knowledge gap, utilized ovariectomized,...
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate cascade molecular pathways which include angiogenesis, glycolysis, and various cellcycle control proteins. As we have shown previously, hypoxia activates STAT5 (signal transducer activator transcription 5) increases its binding activity the GAS element mammary epithelial cells. In this study attempted elucidate mechanism by cyclin D1 is regulated protein under hypoxic conditions. Our...
The hypothalamic-pituitary-adrenal (HPA) axis is the primary endocrine system to respond stress. HPA may be affected by increased level of corticotrophin-releasing factors under chronic stress and administration monosodium glutamate (MSG). purpose this study was investigate whether MSG aggravates variable (CVS)-induced behavioral hormonal changes. Twenty-four adult male Sprague-Dawley rats, weighing 200~220 g, were divided into 4 groups as follows: water (CON), (3 g/kg) (MSG), CVS, CVS with...
Little is known about the time course of aging on interstitial cells Cajal (ICC) colon. The aim this study was to investigate change morphology, ICC, and neuronal nitric oxide synthase (nNOS)-immunoreactive in aged rat. proximal colon 344 Fischer rats at four different ages (6, 31, 74 wk, 2 yr) were studied. immunoreactivity c-Kit, nNOS, anti-protein gene product 9.5, synaptophysin counted after immunohistochemistry. c-kit, stem cell factor (ligand Kit), nNOS mRNA measured by real-time PCR....
Serum response factor (SRF) transcriptionally regulates expression of contractile genes in smooth muscle cells (SMC). Lack or decrease SRF is directly linked to a phenotypic change SMC, leading hypomotility the gastrointestinal (GI) tract. However, molecular mechanism behind SRF-induced GI largely unknown. We describe here how plays functional role regulation SMC contractility via myotonic dystrophy protein kinase (DMPK) and L-type calcium channel CACNA1C. expressed Dmpk Cacna1c into...
The therapeutic potential of adiponectin regulation has received interest because its association with diverse human disease conditions, such as diabetes, obesity, atherosclerosis, and cancer. Phenylethylchromone derivatives from Aquilaria malaccensis-derived agarwood promoted secretion during adipogenesis in bone marrow mesenchymal stem cells, 5,6-dihydroxy-2-(2-phenylethyl)chromone (1) was identified a new chromone derivative. A target identification study the most potent...
To report the defecation patterns of brain-injured patients and evaluate relationship between functional ability colon transit time (CTT) in stroke patients.A total 55 were recruited. Patient interviews medical records review pattern brain injury, anatomical site lesion, bowel habits, constipation score, Bristol scale conducted. We divided into (n=29) non-constipation (n=26) groups according to Rome II criteria for constipation. The CTTs segmental assessed using radio-opaque markers...