A5100689185- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- CRISPR and Genetic Engineering
- Mental Health Research Topics
- Medical Imaging and Pathology Studies
- Obsessive-Compulsive Spectrum Disorders
- Neurogenesis and neuroplasticity mechanisms
- Advanced Radiotherapy Techniques
- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Child Abuse and Trauma
- Dementia and Cognitive Impairment Research
- Olfactory and Sensory Function Studies
- Treatment of Major Depression
- Acupuncture Treatment Research Studies
- Computational Drug Discovery Methods
- Lung Cancer Diagnosis and Treatment
- Psychosomatic Disorders and Their Treatments
- Traumatic Brain Injury Research
- Burn Injury Management and Outcomes
First Affiliated Hospital of Kunming Medical University
2016-2024
Kunming Medical University
2016-2024
Ningbo Medical Center Lihuili Hospital
2024
Ningbo University
2024
Nanchang University
2016-2019
Shanghai Ocean University
2018
Nanjing Medical University
2011-2014
Wuxi People's Hospital
2011-2013
Palmetto Hematology Oncology
2011
Second Military Medical University
2008
Previous MRI studies confirmed abnormalities in the limbic-cortical-striatal-pallidal-thalamic (LCSPT) network or limbic-cortico-striatal-thalamic-cortical (LCSTC) circuits patients with major depressive disorder (MDD), but few have investigated subcortical structural abnormalities. Therefore, we sought to determine whether focal grey matter (GM) changes might be present MDD at an early stage. We recruited 30 first episode, untreated (MDD) and 26 healthy control subjects. Voxel-based...
Brain size and cognitive skills are the most dramatically changed traits in humans during evolution yet genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys (8 first-generation 3 second-generation) carrying human copies of
Little is known about the pathological mechanism of early adult onset depression (EOD) and later (LOD). We seek to determine whether grey matter volume (GMV) change in EOD LOD are different, which could also delineate LOD.In present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 45, were divided into two groups on basis MDD onset: group (age 18-29) 30-44), a total 130 gender-, age-, matched healthy controls (HC) fit for each patient group....
Magnetic resonance imaging (MRI) methods have been used to detect cerebral anatomical distinction between obsessive-compulsive disorder (OCD) patients and healthy controls (HC). Machine learning approach allows for the possibility of discriminating on individual level. However, few studies this automatic technique based multiple modalities identify potential biomarkers OCD. High-resolution structural MRI diffusion tensor (DTI) data were acquired from 48 OCD 45 well-matched HC. Gray matter...
Objective Previous work exhibited different brain grey matter volume (GMV) changes between patients with early adult onset depression (EOD, age 18–29) and later (LOD, 30–44) by using 30-year-old as the cut-off age. To identify whether regional homogeneity (ReHo) are also EOD LOD same age, we used resting-state functional magnetic resonance imaging (fMRI) to detect abnormal ReHo in present study. Methods Resting-state fMRI scans of 58 EOD, 62 LOD, 60 young healthy controls (HC), 52 old HC...
The causality and etio-pathologic risks for patients with Type 2 Diabetes (T2DM) are important areas in modern medicine. Disease complications largely unpredictable T2DM. In the future, we welcome therapeutics of both cutting-edge traditional anti-diabetic treatments management higher efficiency less cost. Expanding medical knowledge, behavior/life-style notification healthcare, genetic/bioinformatics diagnostic promotion, clinical developments (Traditional Chinese Medicine personalized...
The amelioration of insulin resistance by bilobetin is closely related to its hypolipidaemic effect. aim the present study was determine insulin-sensitizing mechanism elucidating effect on lipid metabolism.Rats fed a high-fat diet were treated with for either 4 or 14 days before applying hyperinsulinaemic-euglycaemic clamp. Triglyceride and fatty acids labelled radioactive isotopes used track transportation fate lipids in tissues. activity metabolism-related enzymes β-oxidation rate...
Abstract To explore the brain structural basis underlying behavioral abnormalities associated with Rett syndrome (RTT), we carried out detailed longitudinal noninvasive magnetic resonance imaging analyses of RTT monkey models created by gene-editing, from weaning, through adolescence, till sexual maturation. Here, report abnormal developmental dynamics white matter (WM) microstructures and network topological organizations via diffusion tensor imaging. Specifically, disrupted WM...
The efficacy and prognosis of major depressive disorder (MDD) are limited by its heterogeneity. MDD with melancholic features is an important subtype MDD. present study aimed to reveal the white matter (WM) network changes in depression. Twenty-three first-onset, untreated MDD, 59 non-melancholic patients 63 health controls underwent diffusion tensor imaging (DTI) scans. WM analysis based on graph theory support vector machine (SVM) were used for image data analysis. Compared HC,...
It is crucial to explore the pathogenesis of major depressive disorder (MDD) at early stage for better diagnostic and treatment strategies. was suggested that MDD might be involving in functional or structural alternations brain network level. However, onset MDD, whether whole white matter (WM) alterations level are already evident still remains unclear. In present study, diffusion MRI scanning adopt depict unique WM topology across entire MDD. Twenty-one first episode, short duration (<1...
Emerging evidence has documented the abnormalities of primary brain functions in major depressive disorder (MDD). The brainstem shown to play an important role regulating basic human brain, but little is known about its MDD, especially roles subregions. To uncover this, present study adopted resting-state functional magnetic resonance imaging with fine-grained atlas 23 medication-free MDD patients and 34 matched healthy controls (HC). analysis revealed significantly increased connectivity...
Major depressive disorder (MDD) is a common mental with high morbidity. As part of the limbic system, amygdala important in processing emotional information. Structural and functional connectivity (FC) abnormalities have been observed MDD patients. The present study was carried out to identify features FC adult patients different ages onset. Sixty-nine first-episode untreated 81 healthy controls (CTLs) were included this underwent 3D structural imaging resting-state MRI scanning. CTLs...
Brain ageing is thought to be related geriatric depression, but the relationship between and depression among middle aged individuals unknown. The present study aimed evaluate whether age-related reduction of brain cortical thickness (CT) can found in adult first-episode MDD patients, as well identify possible genetic effect ANK3 gene polymorphism age-relates CT reduction. This recruited 153 patients with a disease duration < 2 years 276 healthy controls (HC), 68 whole regions two SNPs...