Catalina Bazacliu
A5090081994- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Neonatal Health and Biochemistry
- Neonatal and Maternal Infections
- Birth, Development, and Health
- Dialysis and Renal Disease Management
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Cardiovascular Conditions and Treatments
- Chronic Kidney Disease and Diabetes
- Ultrasound in Clinical Applications
- Child Nutrition and Feeding Issues
- Neuroendocrine regulation and behavior
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Pediatric Hepatobiliary Diseases and Treatments
- Retinopathy of Prematurity Studies
- Retinal Diseases and Treatments
- Breastfeeding Practices and Influences
- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
University of Florida
2016-2025
Florida College
2022-2025
UF Health Shands Hospital
2016
Augusta University Health
2012
Abstract Antibiotic use in neonates can have detrimental effects on the developing gut microbiome, increasing risk of morbidity. A majority preterm receive antibiotics after birth without clear evidence to guide this practice. Here metabolomic, and immune marker results from routine early antibiotic symptomatic Neonates (REASON) study are presented. The REASON is first trial randomize or not 48 h birth. Using 16S rRNA sequencing stool samples collected longitudinally for 91 neonates, effect...
<h3>Importance</h3> Understanding why and how extremely preterm infants die is important for practitioners caring these infants. <h3>Objective</h3> To examine risk factors, causes, timing, circumstances of death in a modern cohort <h3>Design, Setting, Participants</h3> A retrospective review enrolled the Preterm Erythropoietin Neuroprotection Trial between December 13, 2013, September 26, 2016, was conducted. total 941 born 24 0/7 27 6/7 weeks gestation at 19 US sites comprising 30 neonatal...
Bronchopulmonary dysplasia (BPD) is the most common complication of very premature birth, leading not only to lifelong respiratory complications, but also developmental impairment. While impact adequate postnatal growth in mitigating complications birth well documented, meeting nutritional needs infants with variable demands that change rapidly disease state remains challenging for neonatologists. In absence effective treatments, focus research BPD on preventative strategies addressing...
Within a randomized prospective pilot study of preterm infants born at less than 33 weeks’ gestation, weekly fecal samples from 19 were collected and metabolomic analysis was performed. The objective to evaluate for differences in metabolites exposed antibiotics vs. not the first 48 h after birth. Metabolomics performed on 123 stool samples. Significant seen no groups, including pathways related vitamin biosynthesis, bile acids, amino acid metabolism, neurotransmitters. Early antibiotic...
Abstract Objective We aim to assess the feasibility of a pragmatic randomized trial antibiotics vs. no in symptomatic premature infants after birth. Most are exposed birth without evidence benefit or harm for this practice. No study date has attempted randomize vs Study Design Infants <33 weeks’ gestation admitted University Florida Neonatal Intensive Care Unit were assigned one three groups birth: (A) high risk – indicated (B) low not (C) eligible un-blinded randomization (no...
Abstract Antibiotic use in neonates can have detrimental effects on the developing gut microbiome, increasing risk of morbidity. A majority preterm receive antibiotics after birth without clear evidence to guide this practice. Here metabolomic, and immune marker results from Routine Early SymptOmatic Neonates (REASON) study are presented. The REASON is first trial randomize symptomatic or not 48 hours birth. Using 16S rRNA sequencing stool samples collected longitudinally for 91 neonates,...
Abstract Within a randomized prospective pilot study of preterm infants born less than 33 weeks gestation, fecal samples were collected weekly and metabolomic analysis was performed. The objective is to evaluate for differences in metabolites exposed antibiotics vs not the first 48hours after birth. Significant seen no group, including pathways related vitamin biosynthesis, bile acids, amino acid metabolism neurotransmitters. Early antibiotic exposure may alter intestinal tract infants....
Early life stress (ELS) is linked to cardiovascular disease in adulthood. We used a mouse model of maternal separation with early weaning (MSEW) study ELS‐mediated adult pathology. hypothesized that MSEW induces vascular dysfunction, and sensitizes male C57BL/6 vasoactive factors. litters were subjected 4h/day (postnatal days (PD) 2–5) 8h/day (PD6‐16), weaned at PD17. Control undisturbed until PD21. performed wire myography on thoracic aortas 12‐week‐old mice. blunted maximum...