A5101984331- Phytochemicals and Medicinal Plants
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Diverse Scientific Research Studies
- Enzyme Production and Characterization
- Nigella sativa pharmacological applications
- Birth, Development, and Health
- Essential Oils and Antimicrobial Activity
- Date Palm Research Studies
- Moringa oleifera research and applications
- Garlic and Onion Studies
- Genetic and Environmental Crop Studies
- Computational Drug Discovery Methods
- Child Nutrition and Water Access
- COVID-19 Clinical Research Studies
- Erythrocyte Function and Pathophysiology
- COVID-19 diagnosis using AI
- Transgenic Plants and Applications
- Kawasaki Disease and Coronary Complications
- Healthcare and Environmental Waste Management
- Brain Metastases and Treatment
- SARS-CoV-2 detection and testing
- Molecular Communication and Nanonetworks
- Genomics, phytochemicals, and oxidative stress
- Tannin, Tannase and Anticancer Activities
Era's Lucknow Medical College and Hospital
2019-2025
Integral University
2023
Indian Institute of Technology BHU
2020
Banaras Hindu University
2020
Yashoda Hospital
2017
Patna Medical College and Hospital
1944
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel etiological agent of disease 2019 (COVID-19). Nigella sativa, commonly known as black seed or cumin, has been historical and traditional plant since thousands years. Based on their therapeutic efficacy, the chief components terpenoids flavonoids were selected from N. sativa seeds oil. This study was designed to check antiviral efficacy main phytoconstituents against five potential targets SARS-CoV-2 using in silico...
Abstract Background Phoenix dactylifera L. has a diverse set of pharmacological properties due to its distinct phytochemical profile. The purpose this study was investigate the anticancer potential seed extract (PDSE) in human breast cancer MDA-MB-231 and MCF-7 cells, as well liver HepG2 efficacy triple-negative followed by silico validation molecular interaction between active components PDSE caspase-3, an apoptosis executioner protein . Methods In study, cell lines were cultured...
Abstract Ajwa dates ( Phoenix dactylifera L.) are used by traditional therapeutic practitioners for several health benefits but most remain to be scientifically validated. In this study, we evaluated the apoptosis-inducing effect of ethanolic extract date pulp (ADP) on human hepatocellular carcinoma (HCC) HepG2 cells. High performance liquid chromatography analysis revealed presence polysaccharide β-D-glucan in ADP extract. Treated HCC cells morphological characteristics apoptosis under...
Moringa oleifera is an excellent source of phenolics and flavonoids comprise various pharmacological activities. The fourth widespread leading cause the patients' death liver cancer. This study was formulated to perform antiproliferative activity fruit (MOF) extract on human cancer HepG2 cells computational validation cell death. line treated with 25, 50, 75, 100, 200 µg/ml MOF for 48 hr, analyzed using MTT assay, nuclear condensation, annexin V-FITC/PI double stain, ROS generation,...
SARS-CoV-2 has been responsible for causing 6,218,308 deaths globally till date and garnered worldwide attention. The lack of effective preventive therapeutic drugs against further worsened the scenario bolstered research in area. N-terminal C-terminal RNA binding domains (NTD CTD) nucleocapsid protein represent attractive drug targets. Naturally occurring compounds are an excellent source novel candidates due to their structural diversity safety. Ten major bioactive were identified...
Intense cancer research is underway to discover possible therapies but no major breakthrough appears be in sight terms of its cure when diagnosed late. The cytostatic and growth inhibitory effect high pressure on cells well documented. In the present study, two cell lines viz . MDA-MB-231 (breast carcinoma) A549 (lung one normal line (Vero) were subjected increased 18 psi a specially constructed chamber. It was found that induced significant change parameters both versus cells. Exposure...
Allium sativum L. has been used medicinally and traditionally since antiquity. This study sought to examine the ethanolic extract (ASEE) in inducing apoptosis human triple-negative breast cancer (TNBC) MDA-MB-231 cells molecular interactions of identified components with cell death markers using silico method. Cytotoxicity ASEE was tested on MCF-7, MDA-MB-231, Normal Vero cells. The ROS production, apoptosis, MMP, cycle were conducted utilizing flow cytometer, western blot also performed for...
There is currently a dearth of specific therapies to treat respiratory infections caused by the three related species coronaviruses viz. SARS-CoV-2, SARS-CoV and MERS-CoV. Prevention from disease safest most convenient alternative available. The present study aimed evaluate preventive therapeutic effect fifteen phytoconstituents medicinal plants Ayurveda against in silico screening. All exhibited rapid GI absorption bioavailability them had no toxicity versus reference drug chloroquine. BAS...
Japanese encephalitis is one of the serious vector-borne viral diseases found worldwide and poses a major threat to public health. Most virus (JEV) infections are subclinical; only 1: 250 1:1000 infected persons develop clinical presentations. Delay in proper diagnosis JE affects timeliness treatment initiation increases mortality rate patients. Therefore, there an extreme need potential biomarkers, which might improve can become basis for development new therapeutics. The microRNAs...
Covid-19 disease, a pandemic condition, is extremely challenging for entire world and human being. The virus, officially called coronavirus 2 (SARS-CoV-2) severe acute respiratory syndromes, widely recognized as the COVID-19 virus recently discovered subsequent disease known COVID-19. In large percentage of cases, SARS-CoV-2 was released due to faecal matter during in currently underway outbreak This eventually proves that wastewater could be cause SARS-CoV-2. Through its function, sewage...
Abstract Prevention from disease is presently the cornerstone of fight against COVID-19. With rapid emergence novel variants SARS-CoV-2 viz . B.1.1.7 (UK), B.1.351 (South Africa), P.1 (Brazil), delta variant B.1.617.2 (India) and recently emerged Omicron B.1.1.529 there an urgent need for prophylactic agents that have ability to strengthen fortify immune system. To this effect, Withania somnifera (WS) its phytoconstituent(s) immense untapped immunomodulatory therapeutic potential. The in...
Caffeic acid, a prevalent phytoconstituent in plants, serves as potent bioactive compound recognized for its robust antioxidant and anticancer properties.It is classified hydroxycinnamic acid renowned role mitigating oxidative stress inflammation.This attribute makes it an invaluable component both natural remedies biomedical research.This study presents approach focused on the development assessment of caffeic loaded nanoemulsion (CALN), targeting potential application combating human...
Carcinomatous meningitis is defined as metastatic infiltration of cerebrospinal fluid (CSF) and leptomeninges by cancer with primary focus at some other site.This not so common complication lung cancer.Bronchogenic carcinoma presenting primarily central nervous symptoms even more uncommon.Demonstration neoplastic cells in the CSF key to diagnosis.This impacts on poor survival well performance status afflicted individual.A rare case such a manifestation described.
Japanese encephalitis virus (JEV) is one of the most important causes acute and uncontrolled inflammatory disease in Asia. Matrix metalloproteinases (MMPs) chemokines play a detrimental role host response to JE disease, aetiology, outcome. Evidently, MMPs are widely circulated brain regulate various process including microglial activation, inflammation, blood-brain barrier disruption as well affects central nervous system (CNS). The present study was assess association single nucleotide...