A5063732125- Ion Channels and Receptors
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Ion channel regulation and function
- Cardiac tumors and thrombi
- Birth, Development, and Health
- Aldose Reductase and Taurine
- Neurobiology and Insect Physiology Research
- Muscle Physiology and Disorders
- Diet, Metabolism, and Disease
- Sarcoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Pharmacological Effects of Natural Compounds
- Neuroendocrine Tumor Research Advances
- Teratomas and Epidermoid Cysts
- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Salivary Gland Tumors Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Retinoids in leukemia and cellular processes
- Heme Oxygenase-1 and Carbon Monoxide
- Wnt/β-catenin signaling in development and cancer
First Affiliated Hospital of Xiamen University
2021-2024
Peking University International Hospital
2020-2022
Peking University
2020-2022
Catholic University of Korea
2014-2020
First Affiliated Hospital of Dalian Medical University
2018
Dalian Medical University
2018
University of Waterloo
2010-2016
Southern Illinois University School of Medicine
2012-2014
Memorial Medical Center
2011-2014
Emmanuel Bible College
2012
Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role specific in development cirrhosis not definite. The present study aims to identify and explore its possible mechanisms promoting cirrhosis.Thirty two cirrhotic patients 27 healthy volunteers were enrolled. Age, gender, Child-Pugh classification serum collected. Liquid chromatography tandem mass spectrometry (LC-MS) was utilized determine concentrations 12 acids...
AKR1B10 (aldo-keto reductase 1B10) is overexpressed in liver and lung cancer, plays a critical role tumour development progression through promoting lipogenesis eliminating cytotoxic carbonyls. secretory protein potential marker; however, little known about the regulatory mechanism of expression. The present study showed that induced by mitogen EGF (epidermal growth factor) insulin AP-1 (activator protein-1) signalling pathway. In human HCC (hepatocellular carcinoma) cells (HepG2 Hep3B), (50...
Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) specifically expressed in the colonic epithelium, downregulated cancer. This study was aimed to investigate etiopathogenic role of AKR1B10 ulcerative CAC.Ulcerative CAC biopsies (paraffin-embedded sections) frozen tissues were collected examine expression. 1B8 (the ortholog human AKR1B10) knockout (AKR1B8(-/-)) mice...
Class IIa histone deacetylases (HDACs) are found both in the cytoplasm and nucleus where they repress genes involved several major developmental programs.In response to specific signals, repressive activity of class HDACs is neutralized through their phosphorylation on multiple N-terminal serine residues 14-3-3-mediated nuclear exclusion.Here, we demonstrate that subjected signal-independent export relies constitutive phosphorylation.We identify EMK C-TAK1, two members microtubule...
Obesity is a major factor central to the development of insulin resistance and type 2 diabetes. The identification characterization genes involved in regulation adiposity, sensitivity, glucose uptake are key design new drug therapies for this disease. In study, we show that polarity kinase Par-1b/MARK2 required regulating metabolism vivo . Mice null Par-1b were lean, hypersensitive, resistant high-fat diet-induced weight gain, hypermetabolic. 18 F-FDG microPET hyperinsulinemic–euglycemic...
Biphasic glucose-stimulated insulin secretion involves a rapid first phase followed by prolonged second of secretion. The biochemical pathways that control these 2 phases are poorly defined. In this study, we used gas chromatography mass spectroscopy-based metabolomics approach to perform global analysis cellular metabolism during biphasic A time course metabolomic the clonal β-cell line 832/13 cells showed glycolytic, tricarboxylic acid, pentose phosphate pathway, and several amino acids...
Defining the key metabolic pathways that are important for fuel-regulated insulin secretion is critical to providing a complete picture of how nutrients regulate secretion. We have performed detailed metabolomics study clonal β-cell line 832/13 using gas chromatography-mass spectrometer (GC-MS) investigate potential coupling factors link Mid-polar and polar metabolites, extracted from β-cells, were derivatized then run on GC/MS identify quantify metabolite concentrations. Three hundred...
The metabolic pathways that are involved in regulating insulin secretion from pancreatic β-cells still incompletely understood. One potential regulator of the phenotype is transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia-inducible (HIF)-1β. ARNT/HIF-1β levels profoundly reduced islets obtained type 2 diabetic patients. However, no study to date has investigated key release lack ARNT/HIF-1β. In this study, we confirm siRNA-mediated knockdown inhibits...
Mitsugumin 53 (MG53) participates in the membrane repair of various cells, and skeletal muscle is major tissue that expresses MG53. Except for regulatory effects MG53 on SERCA1a, role(s) unique functions such as contraction have not been well examined. Here, a new MG53-interacting protein, Orai1, identified muscle. To examine functional relevance MG53-Orai1 interaction, was over-expressed mouse primary or C2C12 myotubes properties were examined using cell physiological biochemical...
The aim of this study is to investigate the effect maternal nicotine exposure (MNE) on development metabolic associated fatty liver disease (MAFLD) in adulthood offspring and underlying mechanism.Pregnant mice (n = 22) were subcutaneously injected with either saline vehicle 11) or twice a day gestational days 11-21. Offspring 176) from both groups weaned at postnatal 21, for 6 months after 96 fed standard chow diet 48) high-fat 48). Serum lipid indicators, function insulin, mitochondrial...
Abstract Objectives Preoperative identification of different stromal subtypes pleomorphic adenoma (PA) the salivary gland is crucial for making treatment decisions. We aimed to develop and validate a model based on histogram analysis (HA) ultrasound (US) images predicting tumour stroma ratio (TSR) in PA. Methods A total 219 PA patients were divided into low-TSR (stroma-low) high-TSR (stroma-high) groups enrolled training cohort (n = 151) validation 68). The least absolute shrinkage selection...
Abstract Stromal interaction molecule 1 (STIM1) along with Orai1 mediates extracellular Ca 2+ entry into the cytosol through a store-operated (SOCE) mechanism in various tissues including skeletal muscle. However, role(s) of STIM2, homolog STIM1, muscle has not been well addressed. The present study, first, was focused on searching for STIM2-binding proteins from among mediating functions. This study used binding assay, quadrupole time-of-flight mass spectrometry, and co-immunoprecipitation...
Type 2 diabetes is associated with impaired nutrient-regulated anaplerosis and insulin secretion in pancreatic β-cells. One key anaplerotic substrate that may be involved regulating release α-ketoglutarate (αKG). Since prolyl hydroxylase domain proteins (PHDs) can metabolize cytosolic αKG, we sought to explore the role of this enzyme regulation β-cell function. The oxygen-sensing PHDs regulate stability hypoxia-inducible factor 1α (HIF1α) as well other proline-containing by catalyzing...
Abstract Stromal interaction molecule 1 (STIM1) mediates extracellular Ca 2+ entry into the cytosol through a store-operated (SOCE) mechanism, which is involved in physiological functions of various tissues, including skeletal muscle. STIM1 also associated with muscle diseases, but its pathological mechanisms have not been well addressed. The present study focused on examining mechanism(s) mutant (R429C) that causes human muscular hypotonia. R429C was expressed mouse primary myotubes, and...
Sildenafil relaxes vascular smooth muscle cells and is used to treat pulmonary artery hypertension as well erectile dysfunction. However, the effectiveness of sildenafil on skeletal benefit its clinical use have been controversial, most studies focus primarily tissues organs from disease models without cellular examination. Here, effects at level were examined using mouse primary myoblasts (the proliferative form stem cells) myotubes, along with single-cell Ca2+ imaging experiments...
Abstract We have investigated whether inflammasomes and pyroptosis are activated in maternal nicotine exposure (MNE) offspring mice they involved MNE‐promoted metabolic associated fatty liver disease (MAFLD) adult offspring. injected pregnant subcutaneously with saline vehicle or twice a day on gestational days 11–21. Offspring from both groups were fed normal diet (ND) high‐fat (HFD) for 6 months at postnatal 21 to develop the MAFLD model. Serum biochemical indices analyzed, histology was...
Purpose: Chilaiditi's syndrome is the hepatodiaphragmatic interposition of colon. Its diagnosis poses challenge to clinicians, and misdiagnosis may results in unnecessary exploratory laparotomy being performed. The purpose this study was report our experience diagnosis, management, clinical outcome patients with syndrome. Methods: Nine cases from April 2005 January 2007 at one institute. characteristic, imaging studies, management were recorded. Results: Six presented abdominal distension (2...
Pathologically, retroperitoneal liposarcoma (RPLS) is a group of malignant tumors, which originates from adipose tissue in space, accounting for almost 70% all tumors. RPLS has no optimal treatment. Surgical resection (R0/R1) the most effective therapy; however, recurrence rate very high. Grossly incomplete surgical (R2) an important risk factor early RPLS.[1] Cisplatin, frequently used platinum-based chemotherapeutic agent, plays significant role treatment various malignancies. Generally,...
Surgery is the main treatment for recurrent retroperitoneal liposarcoma (RPLS). The aim of present study was to explore factors associated with blood loss during surgery RPLS.This retrospective included patients first recurrence RPLS who were treated at our hospital between January 2015 and December 2019. Factors intraoperative identified by univariate multivariate logistic regression analyses. Receiver-operating characteristic (ROC) curve analyses conducted evaluate whether tumor size...
We report a case of fetal nasal chondromesenchymal hamartoma (NCMH) first noted on prenatal ultrasound at 34 weeks. A solid-cystic mass which predominantly hyperechoicgenic and relatively clear margin, was located the left cavity pharynx, with anterior extension moderate blood flow. Further follow-up examination depicted an enlargement tumor. Fetal magnetic resonance imaging (MRI) showed inhomogeneous signal lesion involving ethmoid sinuses, cavity, pharynx. The infant, delivered via...