A5031390279- Diet and metabolism studies
- Gut microbiota and health
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Peptidase Inhibition and Analysis
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Nutrition and Health in Aging
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Neuropeptides and Animal Physiology
- Aquaculture Nutrition and Growth
- Diabetes Treatment and Management
- Genomic variations and chromosomal abnormalities
- Pancreatitis Pathology and Treatment
- Moyamoya disease diagnosis and treatment
- Neonatal Respiratory Health Research
- Lipoproteins and Cardiovascular Health
- Eating Disorders and Behaviors
- Genetic and phenotypic traits in livestock
- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
Kiel University
2018-2025
University Hospital Schleswig-Holstein
2019-2025
University of Lübeck
2019-2025
Universitäts Hautklinik Kiel
2025
Marqués de Valdecilla University Hospital
2023
University Medical Center
2022-2023
Clinical Research Center Kiel
2022
Recent rodent microbiome experiments suggest that besides Akkermansia, Parasutterella sp. are important in type 2 diabetes and obesity development. In the present translational human study, we aimed to characterize our European cross-sectional FoCus cohort (n = 1,544) followed by validation of major results an independent Canadian 438). addition, examined abundance response a weight loss intervention 55). was positively associated with BMI independently reduced α/β diversity low-grade...
Abstract Background The traditional binary classification of diabetes into Type 1 and 2 fails to capture the heterogeneity among patients. This study aims identify characterize subtypes within German FoCus cohort, using ANDIS cohort's framework, explore subtype-specific variations in metabolic markers, gut microbiota, lifestyle, social factors, comorbidities. Methods We utilized data from 416 participants (208 with 208 matched metabolically healthy controls) cohort. Participants were...
The interplay between bile acids (BAs) and metabolic diseases has gained importance in recent years, with a variety of studies investigating their relationship diverging results. Therefore, the present study we performed detailed analysis BA metabolism 492 subjects different phenotypes. Besides microbiomics metabolomics this investigation included silico community to examine interchange microbes as well human host. Our findings revealed distinct changes profiles patients diabetes...
Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. For several years DPP-4 inhibitors in addition to GLP-1 analogues are major importance clinical management obesity and type 2 diabetes. also known as CD26 represents membrane bound protease on surface eukaryotic cell types. Of interest, DPP-4, like ACE2, has been shown serve binding partner for corona-like viruses enter host immune cells. Since metabolic diseases risk factors present COVID-19 pandemic, we examined...
Physical inactivity is one of the leading causes chronic metabolic disease including obesity. Increasing physical activity (PA) has been shown to improve cardiometabolic and musculoskeletal health be associated with a distinct gut microbiota composition in trained athletes. However, impact PA on inconclusive for individuals performing their day-to-day life. This study examined role hand-grip strength microbiome middle-aged adults (40-65 years, n = 350) normal (18.5-24.9 kg/m2 ) overweight...
Background and Purpose— We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods— Copy number variation was identified in high-density single-nucleotide polymorphism microarray data IS patients from CADISP (Cervical Artery Dissection Ischemic Stroke Patients) SiGN (Stroke Genetics Network)/GISCOME (Genetics Ischaemic Functional Outcome) networks. Genetic imbalance, defined as total protein-coding genes affected by copy variations an...
ABSTRACT Background Hypertension affects over 1.28 billion adults worldwide, including a significant number of women. Although the gut microbiome is implicated in onset and progression hypertension, few studies have examined relationship middle-aged Methods Within an established cohort, we investigated between microbiota its metabolites normotensive vs. hypertensive women (n=108) matched for age (56.6±0.91 years) body mass index (24.3±0.24 kg/m²). Fecal analysis was performed using 16S rRNA...
This study re-evaluates the microbial degradation of rutin and genistein, emphasizing health-related metabotypes novel transformation products these compounds. In silico predictions calculations were made to determine molecular formulae metabolites derived from precursor molecules by methylation, sulfation, dehydroxylation. To validate these, anaerobic, ex vivo experiments conducted with pooled fecal samples obese non-obese test persons (n=7 per group) over 48 hours, followed 16S rRNA gene...
Abstract Context Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. It exists in membrane-bound form and soluble (sDPP-4). Initial human studies suggested sDPP-4 to be an adipokine involved metabolic inflammation. However, recent mechanistic data genetically modified mice has questioned these findings. Objectives We examined circulating cohort n = 451 humans with different phenotypes during 3 weight loss interventions (n 101) further clarify its role physiology diseases....
Abstract Background Biomedical and lifestyle factors in Western populations have significantly shifted recent decades, influencing public health contributing to the increasing prevalence of non-communicable diseases (NCDs) that share inflammation as common pathology. Methods We investigated relationship between these 11 NCDs cross-sectional FoCus cohort ( n = 1220), using logistic regression models. Associations with age-at-disease-onset were specifically analyzed for type 2 diabetes (T2D,...
Obesity is associated with a "natriuretic handicap" indicated by reduced N-terminal fragment of proBNP (NT-proBNP) concentration. While gastric bypass surgery improves the natriuretic handicap, it presently unclear if sleeve gastrectomy exhibits similar effects. We examined NT-proBNP serum concentration in n = 72 obese participants without heart failure before and 6 months after (n 28), 19), 3-month 800 kcal/day very-low calorie diet 25). A significant weight loss was observed all...
The present study explored the effects of ascorbic-acid (AA)/retinol and timed inflammation on stemness, regenerative potential, transcriptomics profile gingival mesenchymal stem/progenitor cells’ (G-MSCs). STRO-1 (mesenchymal stem cell marker) immuno-magnetically sorted G-MSCs were cultured in basic medium (control group), with IL-1β (1 ng/mL), TNF-α (10 ng/mL) IFN-γ (100 ng/mL, inflammatory-medium), AA (250 µmol/L) retinol (20 (AA/retinol group) or inflammatory AA/retinol...
The Food Chain Plus (FoCus) cohort was launched in 2011 for population-based research related to metabolic inflammation. To characterize this novel pathology a comprehensive manner, data collection included multiple omics layers such as phenomics, microbiomics, metabolomics, genomics, and metagenomics well nutrition profiling, taste perception phenotyping social network analysis. set-up represent Northern German population of the Kiel region. Two-step recruitment randomised enrolment...
The present study aimed to prove the metyrapone short test in a day clinic be suitable for examining integrity of hypothalamic-pituitary-adrenal (HPA) axis patients with suspected secondary and tertiary adrenal insufficiency identify novel effector molecules acute stress response.44 were prospectively enrolled. Based on stimulated 11-deoxycortisol levels, divided into physiological (11-deoxycortisol ≥70 μg/L) pathological <70 response group. Clinical follow-up examination was performed...
Clara cell 16-kDa protein (CC16) is an anti-inflammatory, immunomodulatory secreted pulmonary with reduced serum concentrations in obesity according to recent data. Studies focused solely on bodyweight, which does not properly reflect obesity-associated implications of the metabolic and reno-cardio-vascular system. The purpose this study was therefore examine CC16 a broad physiological context considering cardio-metabolic comorbidities primary diseases. quantified samples subset FoCus (N =...