A5011745193- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Artificial Intelligence in Healthcare and Education
- Lipoproteins and Cardiovascular Health
- Acute Kidney Injury Research
- Cardiac Valve Diseases and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diabetes Treatment and Management
- Frailty in Older Adults
- Thermal Regulation in Medicine
- Balance, Gait, and Falls Prevention
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetic Foot Ulcer Assessment and Management
- Machine Learning in Healthcare
- COVID-19 Clinical Research Studies
- Medical Coding and Health Information
- Infrared Thermography in Medicine
- Healthcare Operations and Scheduling Optimization
- Peripheral Artery Disease Management
Fu Wai Hospital
2022-2024
Peking Union Medical College Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
State Key Laboratory of Cardiovascular Disease
2022-2024
National Clinical Research
2023
Renji Hospital
2020-2021
Shanghai Jiao Tong University
2020-2021
Abstract Aims Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly binds to ACE2 (angiotensin-converting enzyme 2) facilitate cellular entry. Compared with the lung or tract, human heart exhibits greater expression. However, little substantial damage was found in tissue, and no viral particles were observed cardiac myocytes. This study aims analyse SARS-CoV-2 spike (S) protein proteases at single-cell level, explore involvement COVID-19 improve our understanding of potential...
Lipoprotein(a) is a possible causal risk factor for atherosclerosis and related complications. The distribution prognostic implication of lipoprotein(a) in patients undergoing coronary artery bypass grafting remain unknown. This study aimed to assess the impact high on long-term prognosis grafting.
Abstract Aims Preoperative risk assessment is crucial for cardiac surgery. Although previous studies suggested machine learning (ML) may improve in-hospital mortality predictions after surgery compared to traditional modeling approaches, the validity doubted due lacking external validation, limited sample sizes, and inadequate considerations. We aimed assess predictive performance between ML modelling while addressing these major limitations. Methods results Adult cases (n = 168 565) 2013...
Background Current approaches for initial coronary artery disease (CAD) assessment rely on pretest probability (PTP) based risk factors and presentations, with limited performance. Infrared thermography (IRT), a non-contact technology that detects surface temperature, has shown potential in assessing atherosclerosis-related conditions, particularly when measured from body regions such as faces. We aim to assess the feasibility of using facial IRT temperature information machine learning...
Abstract Objective Warfarin anticoagulation management requires sequential decision-making to adjust dosages based on patients’ evolving states continuously. We aimed leverage reinforcement learning (RL) optimize the dynamic in-hospital warfarin dosing in patients after surgical valve replacement (SVR). Materials and Methods 10 408 SVR cases with dosage–response data were retrospectively collected develop test an RL algorithm that can continuously recommend daily doses multidimensional...
Background: The impact of concomitant impairments left and right ventricular (LV RV) strain on the long-term prognosis acute ST-elevation myocardial infarction (STEMI) is not clear. Methods: We analyzed CMR images followed up 420 first STEMI patients from EARLY Assessment MYOcardial Tissue Characteristics by in (EARLY-MYO-CMR) registry (NCT03768453). These received timely primary percutaneous coronary intervention (PCI) within 12 h examination 1 week (median, 5 days; range, 2–7 days) after...
This manuscript [1] presents an interesting study that explores temporal trends in various performance metrics for different types of prediction models used the in-hospital mortality after cardiac surgery United Kingdom from 2012 to 2019.The data set was divided into 2 periods: 2016 model training and internal validation 2017 2019 external validation.The evaluated 5 models: logistic regression, support vector machine (SVM), random forest, extreme gradient boosting (XGBoost), neural network,...
Abstract Aims Cardiovascular disease (CVD) may not be detected in time with conventional clinical approaches. Abnormal gait patterns have been associated pathological conditions and can monitored continuously by video. We aim to test the association between non-contact, video-based information general CVD status. Methods results Individuals undergoing confirmatory evaluation were included a prospective, cross-sectional study. Gait videos recorded Kinect camera. features extracted from...
Cardiac surgery-associated acute kidney injury (CSA-AKI) is prevalent and increasingly reported. Its diagnosis traditionally follows the Kidney Disease: Improving Global Outcomes (KDIGO) AKI criteria. However, little evidence supports its appropriateness for cardiac surgery patients, particularly regarding subtle serum creatinine change (ΔSCr) that defines mild AKI.
Background: Biomarkers like coronary artery calcium (CAC) and traditional risk factors are well-validated for disease (CAD) assessment but not always available, with limited workup efficiency potential radiation risk. Facial features contain biological information related to atherosclerosis. Aims: We aim extract CAC factor-associated digital biomarkers from facial images evaluate their value in predicting CAD status compared conventional clinical approaches. Methods: Suspected individuals...
Backgrounds: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommended the initiation of multiple supportive measures in patients at high risk for cardiac surgery associated acute kidney injury (CSA-AKI). Heart failure with preserved ejection fraction (HFpEF) was known as a critical factor CSA-AKI. Purpose: Our study designed to assess effectiveness KDIGO and CSA-AKI following coronary artery bypass grafting (CABG) among HFpEF. Methods: This retrospective cohort included...
Backgrounds: Cardiac surgery associated acute kidney injury (CSA-AKI) is a prevalent and detrimental complication following cardiac surgery, with significant effects on both in-hospital long-term morbidity mortality. The renal protective effect of statins for patients undergoing remains unclear. Purpose: This study aims to evaluate the association between perioperative statin therapy risk CSA-AKI coronary artery bypass grafting (CABG). Methods: retrospective cohort included consecutive CABG...
Backgrounds: Cardiac surgery associated acute kidney injury (CSA-AKI) is a prevalent and detrimental complication following cardiac surgery, with significant effects on both in-hospital long-term morbidity mortality. The effect renal prognosis of recombinant human brain natriuretic peptide (rhBNP) for patients undergoing remains unclear. Purpose: This study aims to evaluate the association between postoperative rhBNP risk CSA-AKI coronary artery bypass grafting (CABG). Methods: retrospective...
Background: Recent studies showed that sodium-glucose cotransporter 2 inhibitors (SGLT2i) significantly reduce the risk of atrial fibrillation (AF) and recurrence AF after catheter ablation in diabetic patients. However, there is no evidence a relationship between SGLT2i use incidence postoperative (POAF), common complication coronary artery bypass grafting (CABG). Additionally, protective mechanisms on cardiomyocytes suggest possible association with reduced myocardial injury. Methods: was...
Background: Previous studies have suggested a strong association of liver fibrosis scores with cardiovascular outcomes in patients different diseases, especially people abnormal glucose metabolism. However, the prognostic implication prediabetes or diabetes undergoing coronary artery bypass grafting (CABG) has not been investigated yet. Purpose: This study aimed to investigate impact fibrosis, assessed by Fibrosis-4 (FIB-4) index on clinical following CABG diabetes. Methods: Adult stable...
Background: Cardiac surgery-associated AKI (CSA-AKI) is prevalent and its diagnosis currently adheres to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, commonly used criteria developed for general populations. Limited evidence exists on their appropriateness prognostic value CSA-AKI, which exhibits unique mechanisms clinical courses. Aims: We aimed assess of KDIGO diagnostic CSA-AKI explore potentially more prognostically relevant cardiac surgery. Methods: Patients...