A5100768381- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Medical Research and Treatments
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Pharmacological Effects of Natural Compounds
- Pancreatitis Pathology and Treatment
- Cancer Mechanisms and Therapy
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- MRI in cancer diagnosis
- Endoplasmic Reticulum Stress and Disease
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
Huazhong University of Science and Technology
2015-2025
Tongren Hospital
2025
Shanghai Jiao Tong University
2025
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Shenzhen University
2025
Jiangsu Cancer Hospital
2022-2024
Tongji Hospital
2017-2024
University of Central Florida
2019-2024
West China Hospital of Sichuan University
2024
Doxorubicin (Dox), an antitumor antibiotic, has therapeutic effects on many kinds of tumors. However, Dox can produce some serious side that limit its clinical application. Thus, exploration effective drug targets or active lead compounds against Dox-induced organ damage is necessary. Dioscin, one natural product, potent renal injury and cardiotoxicity. the dioscin hepatotoxicity have not been reported. In this study, results showed significantly ameliorated cell injury, reduced reactive...
Abstract 3-Hydroxybutyrate (3HB) is a small ketone body molecule produced endogenously by the in liver. Previous studies have shown that 3HB can reduce blood glucose level type 2 diabetic (T2D) patients. However, there no systematic study and clear mechanism to evaluate explain hypoglycemic effect of 3HB. Here we demonstrate reduces fasting level, improves tolerance, ameliorates insulin resistance mice through hydroxycarboxylic acid receptor (HCAR2). Mechanistically, increases intracellular...
Globally, 50% of people consume rice (Oryza sativa), which is among the most abundant and extensively ingested cereal grains. Rice bran a by-product industry also considered beneficial waste product processing industry. oil (RBO) created from (20–25 wt% in bran), outermost layer kernel; has lipid content up to 25%; considerable source plethora bioactive components. The main components RBO include high levels fiber phytochemicals, including vitamins, oryzanols, fatty acids, phenolic...
Deregulation of ubiquitin ligases is related to the malignant progression human cancers. F-box only protein 22 (FBXO22), an E3 ligase, a member family. However, biological function FBXO22 in HCC and underlying molecular mechanisms are still unclear. In this study, we explored role its mechanism promoting tumor development. We examined expression normal liver cell lines, tissue microarrays fresh specimens. The correlation between clinical features was analyzed retrospective study 110 pairs...
Bone is the second most frequent site of metastasis for HCC, which leads to an extremely poor prognosis. HCC bone typically osteolytic, involving activation osteoclasts. Long noncoding RNA H19 plays important role in pathogenesis human cancers. Nonetheless, mechanism underlying participation remains unclear.The current study established a mouse model by using serial intracardiac injection and cell isolation obtain cells with distinct ability. was highly expressed these clinical specimens....
Background Since December 2019, the cumulative number of coronavirus disease 2019 (COVID-19) deaths worldwide has reached 1,013,100 and continues to increase as writing. Of these deaths, more than 90% are people aged 60 older. Therefore, there is a need for an easy-to-use clinically predictive tool predicting mortality risk in older individuals with COVID-19.
Peripartum cardiomyopathy (PPCM) is characterized by left ventricular systolic dysfunction and heart failure. However, its pathogenesis not clear. Our preliminary study revealed that autoantibodies against β1-adrenergic receptors (β1R-AABs) M2-muscarinic (M2R-AABs) participated in failure regardless of primary disease. Whether β1R-AABs M2R-AABs participate the PPCM still unknown.Totally 37 diagnosed patients 36 normal pregnant women were enrolled this study. Clinical assessment 2-dimensional...
Our recent study revealed recurrent chromosomal losses and somatic mutations of genes in the Hippo pathway mucinous tubular spindle cell carcinoma (MTSCC). Here, we performed an integrative analysis 907 renal (RCC) samples (combined from The Cancer Genome Atlas in-house studies) Knepper data set microdissected rat nephrons. We identified VSTM2A IRX5 as novel cancer-specific lineage-specific biomarkers MTSCC. then assessed their expression by RNA situ hybridization (ISH) 113 tumors, including...
BACKGROUND The survival and therapeutic outcome vary greatly among glioblastoma (GBM) patients. Treatment resistance, including resistance to temozolomide (TMZ) radiotherapy, is a great obstacle for these therapies. In this study, we aimed evaluate the predictive value of SEC61G on response in GBM MATERIAL AND METHODS Survival analyses were performed assess correlation between expression patients from Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) datasets. Univariate multivariate Cox...
ABSTRACTS This research aimed to explore effects of SIX1 and DACH1 on hepatocellular carcinoma (HCC) cell proliferation, apoptosis cycle. Fifty paired tissues were screened for differentially expressed genes. expressions subjected qRT-PCR western blot in tumor cells. The knockdown efficiency siRNAs transfection cDNAs validated by as well. Then colony formation assay flow cytometry applied observe cycle changes. Immunofluorescence co-localization immunoprecipitation used analyze the...
Objective: APBB1IP is a Rap1-binding protein that mainly acts as regulator of leukocyte recruitment and pathogen clearance through complement-mediated phagocytosis. However, the role in tumor immunity remains unclear. This study was carried out to evaluate prognostic landscape pan-cancer analysis investigate relationship between expression immune infiltration. Methods: We explored pattern value Kaplan-Meier Plotter multiple databases, including TCGA, Oncomine. then assessed correlation cell...
The purpose of this study was to investigate the role endothelial-mesenchymal transition (EndoMT) in pathological retinal angiogenesis and identify key molecular mediators retina angiogenesis. RNA sequencing (RNA-seq) performed on tissue from an oxygen-induced retinopathy (OIR) mouse model analyze gene expression patterns. Gene Set Enrichment Analysis used examine correlation between epithelial-mesenchymal (EMT) sets. Fibronectin (FN1) evaluated endothelial cells, its function assessed...
Percutaneous vertebral augmentation is an effective and commonly surgical treatment for osteoporotic compression fractures, but the problem of bone cement leakage still cannot be prevented. It has been reported that occurs in approximately 20% vertebroplasty procedures, with symptomatic manifestations 1.6% cases. Leakage into spinal canal increases risk cord nerve injury. The objective this study was to introduce a smart assistive device specifically designed facilitate both injection...
18β-Glycyrrhetinic acid (GA) is the active ingredient of traditional Chinese medicine, Glycyrrhrzae Radix et Rhizoma. Here, we explored effects GA on hepatocellular carcinoma (HCC) in vitro and vivo underlying molecular mechanisms. We confirmed that suppressed proliferation various HCC cell lines. Treatment caused G0/G1 arrest, apoptosis autophagy cells. GA-induced were mainly due to unfolded protein response. compared roles ATF4/CHOP IRE1α/XBP1s UPR pathways, which both induced by GA. The...
Fam134b (JK‐1, RETREG1) was first identified as an oncogene in esophageal squamous cell carcinoma. However, the roles of FAM 134B during tumorigenesis hepatocellular carcinoma ( HCC ) and epithelial‐to‐mesenchymal transition EMT were previously unclear. In this study, we investigated function related mechanisms, well how induces . We detected expression a normal hepatic line, lines, fresh specimens, tissue microarray. A retrospective study 122 paired microarrays used to analyze correlation...
Abstract This study aims to investigate the effects of Cyclin D1 silencing on cell cycle, proliferation, and apoptosis hepatocellular carcinoma cells (HCC). Cells were divided into blank group, negative control group (HCC transfected with shRNA), shRNA normal (human liver L‐02 cells). Expressions D1, Caspase‐3, Bcl‐2, C‐myc detected by RT‐qPCR Western blotting. Cell proliferation was Counting Kit‐8. cycle flow cytometry. Tumor xenograft in nude mice performed detect vivo tumorigenesis. HCC...
In order to investigate the potential of nanostructured lipid carriers for efficient and targeted delivery curcumin, pharmacokinetic parameters curcumin-loaded (Cur-NLC) were evaluated in rats after a single intraperitoneal dose Cur-NLC. addition, anticancer activity Cur-NLC against human lung adenocarcinoma A549 cells was verified by cellular uptake study, cytotoxicity apoptosis assay. Bioavailability better than that native curcumin (p > 0.01), as seen from area under plasma...
To the Editor: The study by Allen et al. (May 22 issue) 1 showed that pasireotide reduced risk of clinically relevant pancreatic fistula after either pancreaticoduodenectomy or distal pancreatectomy, whether not duct was dilated. It would be useful to provide details regarding presence a dilated soft texture in group, because they were factors for but pancreatec