A5102725516- Statistical Methods and Inference
- Pulmonary Hypertension Research and Treatments
- Genetic Associations and Epidemiology
- Neuroscience and Neuropharmacology Research
- Advanced Causal Inference Techniques
- Healthcare Policy and Management
- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- Pharmacological Effects and Toxicity Studies
- Reproductive Physiology in Livestock
- Statistical Methods and Bayesian Inference
- Epilepsy research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Nutrition and Health in Aging
- Child Nutrition and Water Access
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Burkholderia infections and melioidosis
- Healthcare and Venom Research
- Bioinformatics and Genomic Networks
- Multiferroics and related materials
- Reproductive Biology and Fertility
- Digital Media and Visual Art
Michigan State University
2024-2025
Norwegian University of Science and Technology
2019-2024
University of Washington
2021-2024
First Hospital of Jiaxing
2023
Jiaxing University
2023
Shenzhen Third People’s Hospital
2023
Southern University of Science and Technology
2023
Shanghai Jiao Tong University
2009-2022
Sichuan Agricultural University
2010-2022
Shanghai Sixth People's Hospital
2022
Background: Pulmonary arterial hypertension (PAH) is a complex disease characterized by progressive right ventricular (RV) failure leading to significant morbidity and mortality. Investigating metabolic features pathways associated with RV dilation, mortality, measures of severity can provide insight into molecular mechanisms, identify subphenotypes, suggest potential therapeutic targets. Methods: We collected data from prospective cohort PAH participants performed untargeted metabolomic...
Decreased mechanical loading results in skeletal muscle atrophy. The transient receptor potential canonical type 1 (TRPC1) protein is implicated this process. Investigation of the regulation TRPC1 vivo has rarely been reported. In present study, we employ mouse hindlimb unloading and reloading model to examine involvement atrophy regrowth, respectively. We establish physiological relevance concept that manipulation could interfere with regrowth processes following an atrophy-inducing event....
Apoptosis signal-regulating kinase 1 (ASK1) not only causes neuronal programmed cell death via the mitochondrial pathway but also is an essential component of signalling cascade during microglial activation. We hypothesize that ASK1 selective deletion modulates inflammatory responses in microglia/macrophages(Mi/Mϕ) and attenuates seizure severity long-term cognitive impairments epileptic mouse model.Mi/Mϕ-specific conditional knockout (ASK1 cKO) mice were obtained for experiments by mating...
To investigate the correlation between initial response to antiepileptic drugs (AEDs) and long-term outcomes after 3 years in patients with newly diagnosed epilepsy.This prospective study included 204 epilepsy, who were followed-up for at least 36 months. The seizure freedom months (36MSF) was evaluated 6 (6MSF) or 12 (12MSF) treatment vs those no (6MNSF) (12MNSF). Univariate analysis a multiple logistic regression model used analyze association of potential confounding variables AEDs.The...
BACKGROUND: Pulmonary arterial hypertension (PAH) is a disease of progressive right ventricular (RV) failure with high morbidity and mortality. Our goal to investigate proteomic features pathways associated RV-focused outcomes including mortality, RV dilation, NT-proBNP (N-terminal pro-B-type natriuretic peptide) in PAH. METHODS: Participants single-institution cohort 3 years follow-up underwent profiling their plasma using 7288 aptamers (targeting 6467 unique human proteins). Partial least...
The development of the follicular wall and apoptosis corresponding cells are dependent upon stage follicle growth levels endogenous hormones. However, prehierarchical follicles in geese is insufficiently known. In order to obtain an understanding about microstructure, geese, firstly, a histological method was used investigate morphological structure follicles. Results showed that thickness granulosa cell layers increased first, then decreased lowest when grew 9-10 mm diameter, theca also...
In contrast to the later stages of follicle development, little is known about characteristics and mechanisms associated with early folliculogenesis in avian species. The objectives present study were examine compare histomorphological molecular changes primordial, primary, secondary follicles from duck goose ovaries during first 6 post-hatching week. Morphological analysis showed that length width both increased steadily weeks 1 5 but acutely at week 6, whereas a greater increment was...
Rationale: The global burden of sepsis is greatest in low-resource settings. Melioidosis, infection with the gram-negative bacterium Burkholderia pseudomallei, a frequent cause fatal endemic tropical regions such as Southeast Asia. Objectives: To investigate whether plasma metabolomics would identify biological pathways specific to melioidosis and yield clinically meaningful biomarkers. Methods: Using comprehensive approach, differential enrichment metabolites was systematically evaluated...
FASN plays a critical role in lipid metabolism, which is involved regulating ovarian follicular development. However, the molecular mechanisms of how regulate function cells still remain elusive. In this study, by overexpression or interference pre-hierarchical follicle granulosa (phGCs) and hierarchical (hGCs), we analyzed their effects on cell transcriptome metabolome profiles using RNA-Seq LC-MS/MS, respectively. The results showed that promoted proinflammatory factors expression...
Background Community health workers (CHWs) have been placed in many rural areas India to increase villagers’ connections basic preventive care. In this study, we describe how pregnant women and mothers of young children react when CHWs inform them that they, or their child, are at high risk pregnancy-related complications early childhood developmental delays, further screening care from a physician is recommended. Methods longitudinal study villages West Bengal, India, mothers, as well aged...
Bi vacancy formation upon epitaxial (001)-strain in BiFeO<sub>3</sub> was investigated by Density Functional Theory (DFT) calculations.
Monitoring outcomes of health care providers, such as patient deaths, hospitalizations, and hospital readmissions, helps in assessing the quality care. We consider a large database on patients being treated at dialysis facilities United States, problem identifying with that are better than or worse expected. Analyses data have been commonly based random fixed facility effects, which shortcomings can lead to unfair assessments. A primary issue is they do not appropriately account for...
<b><i>Objectives:</i></b> Classical methods for combining summary data from genome-wide association studies only use marginal genetic effects, and power can be compromised in the presence of heterogeneity. We aim to enhance discovery novel associated loci heterogeneity effects subgroups defined by an environmental factor. <b><i>Methods:</i></b> present a <i>p</i>value-assisted subset testing associations (pASTA) framework that...
Epitaxial strain is known to significantly influence the structural and functional properties of oxide thin films. However, its impact on point defect concentration has been less explored. Due challenges in experimentally measuring thin-film stoichiometry, computational studies become crucial. In this work, we use first-principles calculations based density theory investigate formation stability Bi vacancies Bi-O vacancy pairs BiFeO
Modeling and drawing inference on the joint associations between single-nucleotide polymorphisms a disease has sparked interest in genome-wide studies. In motivating Boston Lung Cancer Survival Cohort (BLCSC) data, presence of large number single nucleotide interest, though smaller than sample size, challenges their with outcome. similar settings, we find that neither debiased lasso approach (van de Geer et al., 2014), which assumes sparsity inverse information matrix, nor standard maximum...