Martin Christian
A5024221918- Renal Diseases and Glomerulopathies
- Adolescent and Pediatric Healthcare
- Renal Transplantation Outcomes and Treatments
- Ion Transport and Channel Regulation
- Childhood Cancer Survivors' Quality of Life
- Pregnancy and Medication Impact
- Electrolyte and hormonal disorders
- Infant Nutrition and Health
- Renal function and acid-base balance
- Pediatric Urology and Nephrology Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Clinical Nutrition and Gastroenterology
- Breastfeeding Practices and Influences
- Neonatal Health and Biochemistry
- Child Nutrition and Feeding Issues
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Dialysis and Renal Disease Management
- Renal and related cancers
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Immunodeficiency and Autoimmune Disorders
- Organ Donation and Transplantation
Nottingham University Hospitals NHS Trust
2007-2024
The Royal Free Hospital
2024
Roland Hill (United Kingdom)
2024
University College London
2018-2024
Cardiff University
2024
Bambino Gesù Children's Hospital
2023
Queen's Medical Centre
2011-2021
European Society for Paediatric Oncology
2018
Great Ormond Street Hospital
2018
Sydney Children’s Hospitals Network
2017
BackgroundIndividuals with rare kidney diseases account for 5–10% of people chronic disease, but constitute more than 25% patients receiving replacement therapy. The National Registry Rare Kidney Diseases (RaDaR) gathers longitudinal data from these conditions, which we used to study disease progression and outcomes death failure.MethodsPeople aged 0–96 years living 28 types were recruited 108 UK renal care facilities. primary cumulative incidence mortality failure in individuals diseases,...
Up to 95% of children presenting with steroid-resistant nephrotic syndrome in early life will have a pathogenic single-gene mutation 1 24 genes currently associated this disease. Others may be affected by polymorphic variants. There is no accepted diagnostic algorithm for clinical genetic testing. The hypothesis was that the increasing reliability next generation sequencing allows comprehensive one-step investigation group and similar patient groups.This study used screen 446 genes,...
Primary membranoproliferative GN, including complement 3 (C3) glomerulopathy, is a rare, untreatable kidney disease characterized by glomerular deposition. Complement gene mutations can cause familial C3 and studies have reported rare variants in genes nonfamilial primary GN.We analyzed whole-genome sequence data from 165 GN cases 10,250 individuals without the condition (controls) as part of National Institutes Health Research BioResource-Rare Diseases Study. We examined copy number, common...
Abstract Background There is paucity of information on rituximab-associated hypogammaglobulinemia (HGG) and its potential infectious consequences in children treated for idiopathic nephrotic syndrome (INS). Methods A survey was distributed by the European Society Pediatric Nephrology to members. It addressed screening management practices pediatric nephrology units recognizing treating RTX-associated HGG morbidity mortality. Eighty-four centers which had an overall 1328 INS with RTX...
Objective To describe the perspectives on life participation by young adults with childhood-onset chronic kidney disease (CKD). Design Semi-structured interviews; thematic analysis. Setting Multiple centres across six countries (Australia, Canada, India, UK, USA and New Zealand). Participants Thirty aged 18 to 35 years diagnosed CKD during childhood. Results We identified themes: struggling daily restrictions (debilitating symptoms side effects, giving up valued activities, impossible attend...
In children with corticosteroid-sensitive nephrotic syndrome, many relapses are triggered by upper respiratory tract infections. Four small studies found that administration of daily low-dose prednisolone for 5 to 7 days at the time an infection reduced risk relapse, but generalizability their findings is limited location and selection study population.To investigate use treatment infection-related relapses.This double-blind, placebo-controlled randomized clinical trial (Prednisolone in...
Background and objectives Membranoproliferative GN C3 glomerulopathy are rare overlapping disorders associated with dysregulation of the alternative complement pathway. Specific etiologic data for pediatric membranoproliferative GN/C3 lacking, outcome based on retrospective studies without data. Design, setting, participants, & measurements A total 80 prevalent patients underwent detailed phenotyping long-term follow-up within National Registry Rare Kidney Diseases (RaDaR). Risk factors...
<h3>AIMS</h3> To address some of the issues in ongoing debate over optimal diagnostic imaging following childhood urinary tract infection (UTI), by determining risk missing renal cortical scarring which would be detected on a technetium-99m dimercaptosuccinic acid (DMSA) gold standard if ultrasound alone were used, factoring for clinical features (upper or lower tract), UTI recurrence, and age group (infants, preschool, school age). <h3>METHODS</h3> Details recurrence recorded 990 children...
Relapses of childhood steroid-sensitive nephrotic syndrome (SSNS) are treated with a 4- to 8-week course high-dose oral prednisolone, which may be associated significant adverse effects. There is clear association between upper respiratory tract infection (URTI) and relapse development. Previous studies in developing nations have suggested that introducing 5- 7-day daily prednisolone during an URTI prevent the need for treatment prednisolone. The aim PREDNOS 2 evaluate effectiveness 6-day...
<h3>Introduction</h3> Steroid-sensitive nephrotic syndrome (SSNS) is the most common form of kidney disease in children worldwide. Genome-wide association studies (GWAS) have demonstrated SSNS with genetic variation at <i>HLA-DQ/DR</i> and identified several non-<i>HLA</i> loci that aid further understanding pathophysiology. We sought to identify additional associated Sri Lankan European ancestry. <h3>Methods</h3> conducted a GWAS cohort individuals comprising 420 pediatric patients 2339...
In a 12-month, multicenter, open-label study, 106 children were randomized at 4 to 6 weeks after kidney transplantation switch everolimus with reduced TAC (EVR/rTAC) and steroid elimination from month 5 posttransplant or continue standard tacrolimus mycophenolate mofetil (sTAC/MMF) steroids. The cumulative incidence of co-primary efficacy end point (biopsy-proven acute rejection [BPAR], graft loss, death randomization 12) was 10.3% EVR/rTAC 5.8% sTAC/MMF (difference 4.4%; P = .417). BPAR...
Rituximab is an effective treatment for children with steroid dependent or frequently relapsing nephrotic syndrome. The optimum dosing schedule rituximab has not been established. We hypothesized that a single low dose of 375 mg/m2 would have comparable outcomes to higher doses in reducing the frequency relapse and time B cell reconstitution. conducted multicenter retrospective observational cohort study steroid-sensitive Data were extracted from clinical records including dates diagnosis,...
Background Type I pseudohypoaldosteronism (PHA1) is a rare condition characterised by profound salt wasting, hyperkalaemia and metabolic acidosis due to renal tubular resistance aldosterone (PHA1a) or defective sodium epithelial channels (PHA1b systemic PHA). Our aim was review the clinical presentation related genotype in patients with PHA1. Methods A questionnaire-based cross-sectional survey undertaken through British Society of Paediatric Endocrinology Diabetes (BSPED) examining...
CRADLE was a 36-month multicenter study in pediatric (≥1 to <18 years) kidney transplant recipients randomized at 4 6 weeks posttransplant receive everolimus + reduced-exposure tacrolimus (EVR rTAC; n = 52) with corticosteroid withdrawal 6-month or continue mycophenolate mofetil standard-exposure TAC (MMF sTAC; 54) corticosteroids. The incidence of composite efficacy failure (biopsy-proven acute rejection [BPAR], graft loss, death) month 36 9.8% vs 9.6% (difference: 0.2%; 80% confidence...
Background The colon salvages energy from starch, especially when the capacity of small intestine to digest it is limited. aim this study was determine site and relative extent starch digestion fermentation in infants. Methods Thirteen infants (10 male 3 female infants), median age 11.8 months (range, 7.6–22.7 months), were fed a starchy breakfast containing 13C-labeled wheat flour after an overnight fast. Duplicate breath samples obtained before every 30 minutes for 12 hours. Breath 13CO2...