A5019546965- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- COVID-19 and Mental Health
- Air Quality and Health Impacts
- COVID-19 and healthcare impacts
- Emergency and Acute Care Studies
- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Bacterial Infections and Vaccines
- Childhood Cancer Survivors' Quality of Life
- Congenital Diaphragmatic Hernia Studies
- Systemic Lupus Erythematosus Research
- COVID-19 diagnosis using AI
- Kawasaki Disease and Coronary Complications
- Liver Diseases and Immunity
- Mosquito-borne diseases and control
Universitas Gadjah Mada
2018-2025
Rumah Sakit Umum Pusat Dr. Sardjito
2018-2023
Prince Charles Hospital
2021
ADA University
2020
Abstract Background Heterogeneous respiratory system static compliance ( C RS ) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported previous small-case series or studies conducted at a national level. Methods We designed retrospective observational cohort study rapid data gathering from the international COVID-19 Critical Care Consortium to comprehensively describe —calculated as: tidal volume/[airway...
The objective of this study was to examine the effects extreme temperatures on gene signature and pathways airway epithelial cells in mice asthma patients. We investigated temperature exposure at normal (22°C), low (10°C), high (40°C) fluctuation (40°C for 2 h followed by 10°C next h) B6.Sftpc-CreER T2 ;Ai14(RCL-tdT)-D pediatric adult patient's exposed temperatures. observed that Mmp8, Sftpb, Cxcl15 Cd14 were significantly upregulated model. Cma1, Kit, Fdx1, Elf1a, Cdkn2aipnl, Htatsf1,...
Abstract Background The objective of this study was to examine the associations blood inflammatory phenotypes with acute pediatric asthma exacerbations during different seasons and COVID-19 pandemic. Methods A retrospective conducted involving 32,160 patients from January 2008 December 2021. Asthma were categorized based on low (L) high (H) eosinophils (E) neutrophils (N) (LBE/HBE: ≥ 0.25 × 10 9 /L LBN/HBN: 5 /L, respectively) logistic regression used odds ratio (OR) outcome variables....
Sepsis is the leading cause of death worldwide in pediatric populations. Studies low-resource settings showed that majority patients with sepsis still have a high mortality rate.We retrospectively collected records from 2014 to 2019 who had been diagnosed and admitted PICU our tertiary hospital. Cox proportional hazard regression modeling was used evaluate associations between patient characteristics mortality.Overall, 665 were enrolled this study, 364 (54.7%) boys 301 (46.3%) girls. As many...
and importance: A common gastrointestinal presentation of both COVID-19 multisystem inflammatory syndrome in children (MIS-C) is acute abdominal pain, which sometimes mimics appendicitis. Literature describing with infection concurrent appendicitis growing, understanding these patients' clinical picture necessary for their proper treatment.We present a case series six healthy before they developed classic symptoms At the same time, were also found to have confirmed COVID-19. All patients had...
Historically, qualitative research has complemented quantitative biologic and epidemiologic studies to provide a more complete understanding of pandemics. The COVID-19 pandemic generated unique novel challenges for researchers, who have embraced creative solutions including virtual focus groups rapid analyses continue their work. We present our experience conducting multilingual global study healthcare resilience among teams pediatric oncology professionals during the pandemic. an in-depth...
The mortality of dengue shock syndrome (DSS) in children is still high at 12-44%. Assessment DIC initial score using the International Society on Thrombosis and Haemostasis scoring system can help diagnosing treating DIC, while also predicting pediatric patients with DSS.We retrospectively collected data DSS Dr. Sardjito Hospital between January 2017 June 2021 inclusion criteria such as age 1 month to 18 years laboratory parameters taken within first 24 h after workup.Results showed a sample...
The objective of this study was to examine the association between lung lobe-deposited dose inhaled fine particulate matter (PM
Dengue shock syndrome (DSS) in children is a challenging infectious disease due to its high mortality rate. Several factors can contribute the DSS patients' outcomes. Here we defined associated with clinical outcomes of patients Pediatric Intensive Care Unit (PICU).We retrospectively collected data from January 2016 May 2020 who had been diagnosed and admitted PICU our tertiary referral hospital. Bivariate analysis logistic regression were used evaluate independent predictors study...
Bacterial meningitis causes high mortality rates among children. Even with early diagnosis and prompt treatment, around 15% of patients die especially in the first second days after diagnosis. The neutrophil lymphocyte ratio has been reported to be a predicting factor severity outcome for pneumonia sepsis. However, only few studies are available rate as predictor bacterial meningitis. This study aimed know role meningitis.This retrospective was conducted at Dr. Sardjito General Hospital,...
The chest X-ray (CXR) is still an important examination in the diagnosis of pulmonary tuberculosis low- and middle-income countries [1]. degree abnormalities on CXR reflects overall disease severity culture-positive patients independently predicitve outcome [2]. Footnotes This manuscript has recently been accepted for publication ERJ Open Research . It published here its form prior to copyediting typesetting by our production team. After these processes are complete authors have approved...
Indonesia's national response to COVID-19 evolved rapidly throughout 2020. Understanding pandemic and outcomes is crucial for better mitigation strategies ahead. This study describes the characteristics of patients admitted ICU during early stages pandemic.This a multi-centre prospective observational including from twelve collaborating hospitals in Indonesia. All were clinically suspected or laboratory-confirmed cases between January 2020 March 2021. The primary outcome was monthly...
Background Prolonged stay in the pediatric intensive care unit (PICU) reflects not only disease severity and patient health status, but also performance quality of care.
 Objective To to determine whether surgical procedure, severe malnourishment, cardiovascular condition, sepsis, ventilator use were predictors prolonged PICU stay.
 Methods This nested, case-control study was conducted with secondary data from medical records inpatients at Dr. Sardjito General Hospital, Yogyakarta,...
Pneumonia is still a major cause of death and incurs significant morbidity mortality in developing countries. Thus, patients care does not only focus on treatment but also identifying factors that associated with the patient's outcome. Therefore we defined pediatric pneumonia assessed outcome supported by mechanical ventilation children.We performed cohort retrospective study collecting data who admitted to Pediatric Intensive Care Unit (PICU) at Dr. Sardjito General Hospital, from 2014...
and importance: Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies against red blood cells (RBCs) leading to increased hemolysis. Incidence AIHA in patients with beta-thalassemia major 5 100 thalassemia patients.A 15-year-old female patient refractory was unresponsive steroid therapy. In this report, she treated cyclosporine prednisone addition leucodepleted packed cell (PRC). She successfully got remission during one-year monitoring.Cyclosporine an...
To define the prevalence of mortality and identify factors associated with in pediatric patients extraocular retinoblastoma attending tertiary hospital Indonesia.We retrospectively collected medical records from 2013 to 2019 who were diagnosed retinoblastoma. Cox proportional hazard regression analysis 95% confidence interval (CI) was used evaluate association predictors patient outcomes (Hazard Ratio [HR], CI) significance set as p < .05.Overall, 60 included this study for a retrospective...
Background Sepsis remains one of the causes child morbidity and mortality worldwide. The reference standard diagnosis sepsis is blood culture, but its false negative relatively high. Therefore, a validated triage tool needed for rapid diagnosis. In Indonesia, management pediatric are based on Indonesian National Guidelines 2021. Objective To evaluate performance 2021 in diagnosing bacterial PICU. Methods This cross-sectional study was conducted PICU unit Dr. Sardjito Hospital, Yogyakarta,...
BACKGROUND: There exist disparities in the definitions of sepsis between Indonesia and rest world. The aim this study was to evaluate Goldstein definition compared Sepsis-3 pediatric patients.METHODS: A retrospective conducted on 200 patients admitted Pediatric Intensive Care Unit (PICU) from October 2019 2021. We included aged 1 month 18 years old who were PICU with diagnoses such as respiratory infection, intracranial gastrointestinal tract genitourinary blood culture data for our...
and importance: Typhoid fever is an infection caused by Salmonella typhi. The common complications are intestinal perforation typhoid encephalopathy. Cases of with sepsis and/or disseminated intravascular coagulation (DIC) rarely reported, even though endemic in Indonesia.A 4-year-old male referral case from a district hospital was experiencing fever, decrease consciousness massive bleeding his gastrointestinal tract nose. Investigation revealed results the IgM test using Tubex®TF, score +8....
and importance: Congenital cystic adenomatoid malformation (CCAM) is a rare lesion in the lungs. CCAM might present early neonatal period with symptoms of respiratory distress.A 2-year-old girl was admitted to our Pediatric Intensive Care Unit signs severe distress. She had been diagnosed since she three months old. also undergone several procedures such as thoracotomy decortication then, but still suffered some episodes pulmonary infection. In this admission, her computerized thoracic...
Background Nutritional therapy is an important aspect in managing PICU patients. Careful decisions should be made regarding initiation, route of administration, and achievement based on caloric requirements. Many conditions could affect the application nutritional therapy.Objective To investigate implementation during 1st week after admission.Methods We conducted a retrospective study involving 156 children aged 1 month-18 years who were hospitalized for at least 4 days period January 1st,...
and importance: Congenital diaphragmatic hernia (CDH) is a condition characterized by defect in the diaphragm causing protrusion of abdominal organs into thoracic cavity. Comprehensive management, definitive surgical procedures postoperative care are able to significantly reduce morbidity mortality post-herniorrhaphy patients. Here, we reported case post herniorrhaphy pediatric patient with challenge extubation.A 4-month-old girl chief complaint respiratory distress from was admitted our...
Intracranial infection is a major cause of emergency and death in children. To assist clinical decision-making patient management, we conducted study about factors associated with mortality. This aimed to evaluate mortality pediatric patients intracranial infection.We performed cohort retrospective our tertiary hospital the outcomes admitted intensive care unit (PICU) from 2014 2018. The Chi-square test was determine significance predictor, p < 0.05 considered indicate statistically...