A5112281747- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Renal Transplantation Outcomes and Treatments
- Advanced MRI Techniques and Applications
- Mechanical Circulatory Support Devices
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Potassium and Related Disorders
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Electrolyte and hormonal disorders
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Lipoproteins and Cardiovascular Health
- Signaling Pathways in Disease
- Cardiac electrophysiology and arrhythmias
- Bone and Dental Protein Studies
- Peptidase Inhibition and Analysis
Vanderbilt University Medical Center
2013-2024
VA Tennessee Valley Healthcare System
2013-2024
Nashville VA Medical Center
2019
Lipscomb University
2017-2018
Boston University
2002-2016
Vanderbilt University
2008-2016
Newton Wellesley Hospital
2016
Brigham and Women's Hospital
2002-2016
Harvard University
2016
Tufts University
2016
Background: Conversations about goals of care and cardiopulmonary resuscitation (CPR)/intubation for patients with advanced heart failure can be difficult. This study examined the impact a video decision support tool patient checklist on advance planning failure. Methods: was multisite, randomized, controlled trial video-assisted intervention versus verbal description in 246 ≥64 years age an estimated likelihood death >50% within 2 years. Intervention participants received...
For patients awaiting heart transplant, hepatitis C-positive donors offer an opportunity to expand the donor pool, shorten wait times, and decrease wait-list mortality. While early reported outcomes among few transplant recipients have been promising, knowledge of 1-year in larger cohorts is critical shared decision-making with about this option.To better define association volumes, duration, transmission cure donor-derived C, morbidity mortality at 1 year.This was a prospective,...
In patients with chronic heart failure (HF), the pulmonary circulation is a major source of endothelin-1 (ET), and ET levels correlate vascular resistance (PVR). The role in causing vasoconstriction HF not known, however, part because confounding effects receptor antagonists on systemic hemodynamics.To directly test hypothesis that causes HF, we infused selective ET(A) antagonist sitaxsentan at increasing rates (0.3125 to 10 mg/min) into left lower-lobe segmental artery 8 ventricular (LV)...
Osteopontin, also known as cytokine Eta-1, plays an important role in postmyocardial infarction remodeling by regulating collagen accumulation. Aldosterone promotes synthesis and structural of the heart. The osteopontin aldosterone-induced fibrosis myocardial is unknown. Osteopontin expression left ventricular functional were determined wild-type knockout mice after aldosterone infusion.Immunohistochemical analyses showed increased interstitial protein ventricle 7 days infusion. After 4...
Increased myocyte loss and extracellular matrix (ECM) turnover are central mechanisms that contribute to pathological myocardial remodeling in chronic heart failure (HF). We tested the hypothesis episodes of acute HF syndrome (AHFS) associated with transient increases markers injury ECM beyond those observed stable HF.Markers were assessed 80 patients prospectively divided into 3 groups: AHFS (n=39); systolic (n=21); control subjects without (n=20). Myocyte was by measuring plasma troponin...
Chronic hypercapnia is commonly found in patients with severe hypoxic lung disease and associated a greater elevation of pulmonary arterial pressure than that due to hypoxia alone. We hypothesized worsens hypertension by augmenting vascular remodeling vasoconstriction (HPV). Rats were exposed chronic [inspiratory O 2 fraction ([Formula: see text]) = 0.10], (inspiratory CO 0.10), hypoxia-hypercapnia text]= 0.10, inspiratory or room air. After 1 3 wk exposure, muscularization resistance blood...
Background: Heart transplantation (HT) is the definitive therapy for end-stage heart failure. However, with improving post-HT survival in modern era, recipients are increasingly cumulatively exposed to unique risk factors cardiovascular-kidney-metabolic (CKM) dysfunction. An expanded understanding of incidence and prevalence CKM dysfunction may inform screening therapeutic strategies mitigate adverse events. Objectives: The aim this study was characterize adult pediatric HT at a high-volume...
Background Left ventricular ( LV ) energy supply‐demand imbalance is postulated to cause “energy starvation” and contribute heart failure HF in nonischemic dilated cardiomyopathy NIDCM ). Using cardiac magnetic resonance CMR [ 11 C] acetate positron emission tomography PET ), we evaluated perfusion oxidative metabolism the effects of spironolactone on relations. Methods Results Twelve patients with underwent at baseline after ≥6 months therapy added a standard regimen. The myocardial reserve...
Anticoagulation reversal agents (ARAs) can minimize bleeding complications associated with mechanical circulatory support devices (MCSDs) explantation at the time of heart transplantation (HT); data on thromboembolic (TE) risk ARAs are limited in this patient population. In single-center study, we retrospectively analyzed 118 consecutive adults who were supported durable MCSDs and underwent HT between May 2013 October 2016. Patients categorized based intraoperative use (recombinant factor...
Abstract Aims We sought to clarify the role of ventriculo–arterial (V–A) coupling in treatment nonischemic dilated cardiomyopathy (NIDCM) by adding a mineralocorticoid receptor antagonist (MRA) conventional anti‐failure therapy. Methods and results employed cardiac magnetic resonance imaging quantify left ventricular (LV) contractility V–A normal subjects at rest ( n = 11) patients with NIDCM 12) before after long term therapy, which MRA was added After ≥6 months' patients, LV volumes mass...