A5101852736- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Endometriosis Research and Treatment
- Lymphatic System and Diseases
- Hedgehog Signaling Pathway Studies
- Intraperitoneal and Appendiceal Malignancies
- Cancer Cells and Metastasis
- Cancer and Skin Lesions
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- Cancer Research and Treatments
- Blood transfusion and management
- Nonmelanoma Skin Cancer Studies
- RNA modifications and cancer
- Vitamin K Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic and Kidney Cyst Diseases
- Ovarian cancer diagnosis and treatment
- Nerve injury and regeneration
- Congenital heart defects research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
- Tissue Engineering and Regenerative Medicine
Peking University
2024
Peking University Third Hospital
2024
University of Tsukuba
2023
China Medical University
2018-2021
Second Affiliated Hospital of Zhejiang University
2021
National Heart Lung and Blood Institute
2020
National Institutes of Health
2020
Beijing Shijitan Hospital
2019
Capital Medical University
2019
Beijing Anzhen Hospital
2019
Difficulty in wound healing is one common complication of diabetes mellitus. The study explored whether the therapeutic effect human umbilical cord mesenchymal stem cells (hUCMSCs) on diabetic ulcer was enhanced by activation Wnt signaling pathway. Rat model established intraperitoneal injection Streptozotocin (STZ). hUCMSCs were purified and seeded collagen–chitosan laser drilling acellular dermal matrix (CCLDADM) scaffold, which subsequently implanted into cutaneous normal rats, followed...
Abstract Blood and lymphatic vessels structurally bear a strong resemblance but never share lumen, thus maintaining their distinct functions. Although initially arise from embryonic veins, the molecular mechanism that maintains separation of these two systems has not been elucidated. Here, we show genetic deficiency Folliculin, tumor suppressor, leads to misconnection blood in mice humans. Absence Folliculin results appearance lymphatic-biased venous endothelial cells caused by ectopic...
Abstract OBJECTIVES The use of cardiopulmonary bypass (CPB) in cardiac surgery is a major risk factor for postoperative bleeding. We hypothesized that consumptive coagulopathy and haemodilution influence the coagulation factors; therefore, we aimed to estimate activity profiles factors II, VII X during CPB circulation. METHODS A 120-min was surgically established cynomolgus monkeys (n = 7). Activities were measured at 6 time points experiment (baseline, 0, 30, 60, 120 min 60 after bypass)....
Extramammary Paget's disease (EMPD), a rare skin malignancy with non-specific manifestations, is often misdiagnosed as eczema of scrotum or tinea cruris. Although the diagnosis EMPD could be confirmed by biopsy, it can delayed patients are reluctant to receive invasive operations. Herein, we investigated serum miRNA expressions and compared that cruris well health volunteers for potential diagnostic markers EMPD. Altogether 45 subjects including 16 diagnosed EMPD, 12 17 healthy were enrolled...
Peritoneal metastasis frequently occurs in patients with advanced ovarian cancer and is the main basis for a poor prognosis. The mechanism underlying preferential spread to peritoneum not well understood.Herein, we investigated significance fibrosis of mesothelial cells promoting peritoneal implantation cancer. We have assessed cell fibroblast transformation process tissues omentum fibrotic release chemokines promote dissemination by scanning electron microscopy, ELISA, Western blot,...
Perivascular adipose-derived stem cells (PVASCs) can contribute to vascular remodeling, which are also capable of differentiating into multiple cell lineages. The present study aims investigate the mechanism PVASC differentiation toward smooth muscle (SMCs) and endothelial (ECs) as well its function in neointimal hyperplasia.Single-cell sequencing bulk mRNA were applied for searching key genes regarding role remodeling. PVASCs induced differentiate SMCs ECs vitro, was quantitatively...
Appropriate immunohistochemistry (IHC) scoring criteria can guarantee the reliability of mutation detection results. Most current studies suggest that "four-grade criterion" may be best among all systems. The aim this study is to discuss influence different four-grade on test results.Three were respectively used evaluate EGFR status 83 cases non-small cell lung cancer (NSCLC) samples. sensitivity, specificity, positive predictive value (PPV), negative (NPV), agreement each criterion compared...
To determine the application of serum thymidine kinase 1 (STK1) in general health screening for early detection premalignant/early malignant tumors.A cross sectional study was carried out 26 055 screenings from 8 centers Changsha 2011. The concentration STK1 determined by a sensitive chemiluminescent dot blot ECL assay.In elevated group 60.35% showed diseases with higher risk premalignant/ cancerous progression. positive rate (>2.0 pmol/L) 2.61%. There significantly moderate/severe type...
Abstract Natto, known for its high vitamin K content, has been demonstrated to suppress atherosclerosis in large-scale clinical trials through a yet-unknown mechanism. In this study, we used previously reported mouse model, transplanting the bone marrow of mice expressing infra-red fluorescent protein (iRFP) into LDLR-deficient mice, allowing unique and non-invasive observation foam cells iRFP atherosclerotic lesions. Using 3 natto strains, meticulously examined effects varying levels on...