A5101672256- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Angiogenesis and VEGF in Cancer
- Heavy Metal Exposure and Toxicity
- Axon Guidance and Neuronal Signaling
- Advanced Proteomics Techniques and Applications
- Biosensors and Analytical Detection
- Lung Cancer Treatments and Mutations
- RNA regulation and disease
- Vibrio bacteria research studies
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Planarian Biology and Electrostimulation
- Apelin-related biomedical research
- Bioinformatics and Genomic Networks
- Hippo pathway signaling and YAP/TAZ
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Dye analysis and toxicity
- Ferroptosis and cancer prognosis
- Cellular transport and secretion
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2009-2023
Wenzhou Medical University
2009-2023
Zhejiang Academy of Medical Sciences
2022
Xi’an Children’s Hospital
2022
Wuxi People's Hospital
2021
Nanjing Medical University
2021
First Affiliated Hospital of Xi'an Jiaotong University
2018-2020
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2020
Increasing evidence indicates that the dysregulation of microRNAs (miRNAs) play critical roles tumor progression and metastasis, but very few papers had reported function miR-9-5p in lung cancer, especially NSCLCs. In this study, we investigated role non-small cell cancers (NSCLCs). MiR-9-5p level were analyzed 62 clinical NSCLC tissue samples adjacent normal tissues by RT-PCR. The target was predicted TargetScan luciferase reporter assay used to verify binding site on TGFBR2 mRNA. MTT...
Mounting evidence indicates that microRNAs play important roles in the development of various cancers. Aberrant expression microRNA-199a-5p has been frequently reported cancer studies; however, mechanistic details role colorectal still remain unclear. Our study aimed to explore cells by targeting Rho-associated coiled coil-containing protein kinase 1. Here, we showed was significantly downregulated cell lines and tissue samples associated with a poor prognostic phenotype. MicroRNA-199a-5p...
Aims: To investigate the concentration of urinary 8-hydroxydeoxyguanosine (8-OHdG) among electroplating workers in Taiwan. Methods: Fifty were selected from five chromium (Cr) plants central The 20 control subjects office with no previous exposure to Cr. Urinary 8-OHdG concentrations determined using high performance liquid chromatography electrochemical detection. Results: Cr (1149.5 pmol/kg/day) higher than those group (730.2 pmol/kg/day). There was a positive correlation between and ( r =...
Purpose:The influence of X-inactive specific transcript (XIST) and X-chromosome inactivation associated long non-coding RNAs (lncRNAs) just proximal to XIST (JPX) on hepatocellular carcinoma (HCC) remains controversial in light previous reports, which the present study aimed verify. Materials Methods:The DIANA lncRNA-microRNA (miRNA) interaction database was used explore miRNA interactions with JPX or XIST.JPX, XIST, miR-155-5p expression levels paired HCC specimens adjacent normal tissue...
Objective To investigate the prognostic significance of 23 matrix metalloproteinase ( MMP) genes in patients diagnosed with ovarian carcinoma. Methods The MMP carcinoma was investigated using Kaplan–Meier plotter (KM plotter), which uses gene expression data and overall survival information cancer that were downloaded from Gene Expression Omnibus, Cancer Biomedical Informatics Grid Genome Atlas datasets. correlation between mRNA levels individual MMPs (MMP2, MMP9, MMP10, MMP12, MMP13 MMP25)...
Recently, long non-coding RNAs (lncRNAs) were involved in promoting gastric cancer (GC) initiation and progression. In the current study, we revealed that expression level of LINC02163 was elevated GC cell lines tissues. Knockdown inhibited cells growth invasion both vitro vivo. Mechanismly, exerted as a ceRNA negatively regulated miR-593-3p expression. addition, FOXK1 identified down-stream target miR-593-3p. The miR-593-3p/FOXK1 axis mediated LINC02163's effect on GC. To best our...
Endothelial progenitor cells (EPCs) can migrate to the tumor tissue and enhance angiogenesis of hepatocellular carcinoma (HCC); thus, they are associated with a poor prognosis. However, specific molecular mechanism underlying homing EPCs HCC neovasculature remains unrevealed. Co-culture experiments endothelial modulation EphA1 were performed in vitro. Using as angiogenic promoters by injecting them into xenograft-bearing nude mice via their tail veins test ability changed according different...
Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined role of miR-1 in mobility migration gastric cells. was down-regulated Sorcin, which supports invasion, highly expressed cell lines as compared to control. The overexpression significantly inhibited cells, while, its knockdown exerted an oppoiste effect. In addition, while suppressed expression siRNA Sorcin counteracted effect inhibitor on...
Previous studies have reported on several genetic variants related to breast cancer, but a substantial proportion of mutation loci not yet been identified. In the current study, we aimed evaluate association between single nucleotide polymorphisms (SNPs) interleukin-10 (IL-10) and susceptibility cancer in Shaanxi Han women China.Six SNPs were genotyped 530 patients 628 healthy from First Affiliated Hospital Xi'an Jiaotong University Hospital. Odds ratios 95% confidence intervals calculated...
Numerous reports have found that long non‑coding (lnc) RNAs were associated with pancreatic cancer (PC) initiation and development. The lncRNA titin antisense RNA 1 (TTN‑AS1) was identified as a tumor promoter in certain types of cancer; however, its role mechanism PC remain unclear. aim the present study to investigate TTN‑AS1 elucidate underlying mechanism. Reverse transcription‑quantitative PCR analysis performed examine mRNA expression level TTN‑AS1, microRNA(miR)‑589‑5p forkhead box...
Diabetic patients are more sensitive to ischemic injury than non-diabetics. Endoplasmic reticulum (ER) stress has been reported be closely associated with the pathophysiology of in diabetes. The aim present study was investigate mechanisms involved progression diabetes complicated by myocardial infarction (MI) and further verify role CCAAT/enhancer binding protein (C/EBP)-homologous (CHOP) using an vitro model diabetes/MI. rats were exposed 65 mg/kg streptozotocin (STZ) left anterior...
Objectives Listeria meningoencephalitis (LMM) is very rare in healthy children. We aimed to assess the clinical features, differential diagnosis, treatment options, and outcomes of LMM immunocompetent children through a retrospective study. Methods The symptoms, laboratory findings, imaging antibiotic use, metagenomic next-generation sequencing (mNGS) results cerebrospinal fluid (CSF) were obtained from who diagnosed with admitted Xi'an Children's Hospital May 2018 July 2020. Results data 8...
Previous studies have shown that miR-224 regulates the progression of liver cancer. The aim this study was to investigate underlying mechanisms.The miR-224, p-STAT3 and SMAD4 expression levels were checked with tissue or/and serum samples HCC patients by qRT-PCR or IHC methods. regulatory role IL-6 in investigated Western-blot. targeted gene verified both Western-blot luciferase reporter assay. Furthermore, carcinogenesis cell experiments vitro mouse xenograft model vivo imaging vivo.It...
Networks of nanotubes and microtubules are highly valued in cellular communication, collective cancer movement has been revealed to be associated with cell information exchange. In the present study, communication was demonstrated participate mammosphere growth, differentiation invasion. By promoting differentiation, networks cells microtubule‑like structures were verified. Analyses cycle progression, stemness markers gene expression indicated that mammospheres had characteristics...
NLIPMT, as a tumor suppressive lncRNA, has only been investigated in breast cancer, while its roles other types of cancer remain unknown. This study aimed to explore the role NLIPMT colorectal (CRC).Expression levels and TGF-β1 two CRC tissue (Non-tumor tissues tissues) were measured compared by qRT-PCR paired t-test, respectively. Correlations between expression analyzed performing linear regression. The effects transfections on cell invasion migration evaluated Transwell assays.We found...
Radiotherapy stands as a promising therapeutic modality for colorectal cancer (CRC); yet, the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC remission.
Abstract Regulated ER-to-Golgi trafficking is a fundamental cellular process that enables ER-resident transcription factors to sense perturbations in the ER environment and activates transcriptional programs restore homeostasis. Current models suggest sensor activation initiated by dissociation from its binding partners. Here we challenge this model demonstrating unfolded protein ATF6 sorted Golgi as newly synthesized peripheral membrane beyond reach of retainer, translocon inhibition alone...
Abstract Treatment and relevant targets for breast cancer (BC) remain limited, especially triple-negative BC (TNBC). We quantified the proteomes of 76 human cell lines using data independent acquisition (DIA) based proteomics, identifying 6091 proteins. then established a 24-protein panel distinguishing TNBC from other types. Integrating prior multi-omics datasets with present proteomic results to predict sensitivity 90 drugs, we found that proteomics improved drug predictions. The drugs was...