A5004327096- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Pain Management and Treatment
- Acute Ischemic Stroke Management
- Muscle activation and electromyography studies
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Dementia and Cognitive Impairment Research
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Dietary Effects on Health
- Long-Term Effects of COVID-19
- Anesthesia and Pain Management
- Heart Rate Variability and Autonomic Control
- Spinal Cord Injury Research
- Climate Change and Health Impacts
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Diet and metabolism studies
- Healthcare Systems and Practices
- Osteoarthritis Treatment and Mechanisms
- Neurological Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Ferrocene Chemistry and Applications
University of Oklahoma Health Sciences Center
2022-2025
Universidade de São Paulo
2017-2025
University of Oklahoma
2024-2025
Oklahoma City University
2025
Northwestern University
2020-2024
Harvard University
2016-2022
Spaulding Rehabilitation Hospital
2016-2022
Massachusetts General Hospital
2020-2022
Instituto de Neurociencia Biomédica
2017-2020
Topiwala National Medical College & BYL Nair Charitable Hospital
2006-2012
Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI critical for comprehending disease progression and enabling preventative intervention.
Phantom limb pain (PLP) is a frequent complication in amputees, which often refractory to treatments. We aim assess factorial trial the effects of transcranial direct current stimulation (tDCS) and mirror therapy (MT) patients with traumatic lower amputation; whether motor cortex plasticity changes drive these results. In this large randomized, blinded, 2-site, sham-controlled, 2 × trial, 112 participants amputation were randomized into treatment groups. The interventions active or covered...
Abstract Impaired cerebrovascular function contributes to the genesis of age‐related cognitive decline. In this study, hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network predict dysfunction older adults. Cerebromicrovascular working memory healthy young ( n = 21, 33.2±7.0 years) aged 30, 75.9±6.9 participants are assessed. To determine NVC functional connectivity (FC) during a (n‐back) paradigm, oxy‐ deoxyhemoglobin concentration changes from...
Abstract Introduction The exact mechanisms underlying the development and maintenance of phantom limb pain (PLP) are still unclear. This study aimed to identify factors affecting intensity in patients with chronic, lower limb, traumatic PLP. Methods is a cross‐sectional analysis We assessed amputation‐related pain‐related clinical demographic variables. used univariate multivariate models evaluate associated modulating PLP residual (RLP) intensity. Results included 71 unilateral amputees....
BackgroundAlthough evidence has indicated a positive effect of transcranial direct current stimulation (tDCS) on reducing pain, few studies have focused the elderly population with knee osteoarthritis (KOA).ObjectiveTo evaluate whether tDCS reduces KOA pain in individuals dysfunctional descending inhibitory system (DPIS).MethodsIn double-blind trial, ≥ 60 years and DPIS, we randomly assigned patients to receive 15 daily sessions 2 mA over primary motor cortex (anode) contralateral...
Mild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up 20% of the aging population worldwide. Patients with MCI have an annual conversion rate dementia 15-20%. Thus, conditions that increase from are utmost public health concern. The COVID-19 pandemic poses significant impact on our decline as one leading complications following recovery acute infection. Recent findings suggest increases in older adults. Hence, we aim uncover mechanism for induced and progression pave...
Background: Despite the multiple available pharmacological and behavioral therapies for management of chronic phantom limb pain (PLP) in lower amputees, treatment this condition is still a major challenge results are mixed. Given that PLP associated with maladaptive brain plasticity, interventions promote cortical reorganization such as non-invasive stimulation methods including transcranial direct current (tDCS) mirror therapy (MT), respectively, may prove to be beneficial control PLP. Due...
Selective serotonin reuptake inhibitors (SSRIs) are currently widely used in the field of neuromodulation not only because their anti-depressive effects but also due to ability promote plasticity and enhance motor recovery patients with stroke. Recent studies showed that fluoxetine promotes after stroke through its on serotonergic system enhancing outputs facilitating long term potentiation, key factors neural plasticity. However, little is known regards exact mechanisms underlying these...
Introduction Fibromyalgia (FM) is a common debilitating condition with limited therapeutic options. Medications have low efficacy and are often associated adverse effects. Given that FM defective endogenous pain control system central sensitisation, combining interventions such as transcranial direct current stimulation (tDCS) aerobic exercise (AE) to modulate pain-processing circuits may enhance control. Methods analysis A prospective, randomised (1:1:1:1), placebo-controlled, double-blind,...
Data on the precise mechanisms of complex interactions factors related to clinical impact knee osteoarthritis (KOA) in elderly population remain limited. To find predictors that explain pain intensity, physical function, and quality life KOA subjects, we performed a cross-sectional analysis baseline data from randomized trial. The trial included 104 subjects (aged ≥60) with dysfunctional endogenous pain-inhibitory system activity assessed by conditioned modulation (CPM). Three multiple...
Background. Although recent evidence has shown a new role of fluoxetine in motor rehabilitation, results are mixed. We conducted randomized clinical trial to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with increases upper limb function stroke. Methods. Twenty-seven hemiparetic patients within 2 years ischemic stroke were into 3 groups: Combined (active rTMS + fluoxetine), Fluoxetine (sham or Placebo placebo fluoxetine). Participants received 18 sessions...
There are multiple available treatments to enhance stroke rehabilitation, although few interventions have confirmed significant clinical improvements on motor function in pivotal Randomized Clinical Trials. Development of large Trials is limited by several barriers and low enrollment rate considered an important factor. Consequently, most the evidence comes from small sample size studies, often leading conclusions. According National Institute Health (NIH), about 80% trials United States do...
Advanced methods of gait research, including approaches to quantify variability, and orderliness/regularity/predictability, are increasingly used identify patients at risk for the development cognitive impairment. Cerebral small vessel disease (CSVD) is highly prevalent in older adults known contribute vascular impairment dementia (VCID). Studies preclinical models demonstrate that subclinical alterations precede CSVD-related coordination. In humans, CSVD also associates with abnormalities....
The development of vascular neurology as the primary specialty for stroke evaluation and treatment is a relatively recent advancement. Vascular well-established in United States, ensuring most patients receive specialized care, but many globally are managed by physicians without training cerebrovascular neurological medicine that partly manifested availability institutions incorporate dedicated training. Our goal to evaluate providers worldwide identify who leading care different regions,...
Background: Reperfusion therapies are highly time-sensitive, necessitating streamlined protocols to ensure that each step meets target times. This is especially critical for wake-up strokes where emergent brain magnetic resonance imaging (eMRI-brain) included in the evaluation process. Stroke alerts, particularly patients with aphasia or altered mental status, present additional challenges confirming absence of metal foreign bodies, leading time-consuming imaging. Implementing integrate a...
Access to acute stroke care varies widely worldwide, with significant gaps in low- and middle-income countries rural areas. Ensuring equitable access requires a standardized approach identify current coverage potential sites for new centers. In the U.S., center distribution is inconsistent across states, around 77% of counties deemed "medical deserts" due lack healthcare services. Methods: We conducted comprehensive survey hospitals Oklahoma assess accessibility therapies. gathered data on...
Background: Stroke is a leading cause of long-term disability worldwide. Timely and adequate rehabilitation crucial for post-stroke recovery, but access limited due to an overburdened healthcare system, medical personnel shortages, insurance barriers. Rehabilitation especially stroke survivors in rural low-income regions. Innovative solutions like telerehabilitation are needed expand access. This study examines current practices, costs, global models, as well barriers utilization. Methods:...
Cancer resistance to chemotherapeutic agents such as cisplatin presents a significant challenge, leading treatment failure and poor outcomes. Novel metal-based compounds offer promising strategy overcome drug enhance efficacy. Four Ru(II) complexes with fenamic acid derivatives were synthesized characterized: [Ru(L)(bipy)(dppp)]PF6, where L represents (HFen, complex 1), mefenamic (HMFen, 2), tolfenamic (HTFen, 3), flufenamic (HFFen, 4). Their composition was supported by molar conductivity,...