A5043048511- Neuroinflammation and Neurodegeneration Mechanisms
- Sodium Intake and Health
- Neurological Disease Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Cerebrospinal fluid and hydrocephalus
- S100 Proteins and Annexins
- Immune cells in cancer
- Advanced Glycation End Products research
- Cystic Fibrosis Research Advances
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Management of metastatic bone disease
- Eicosanoids and Hypertension Pharmacology
- Spinal Dysraphism and Malformations
- Acute Ischemic Stroke Management
- Peroxisome Proliferator-Activated Receptors
- Neonatal Respiratory Health Research
- Menopause: Health Impacts and Treatments
- Renin-Angiotensin System Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Blood Pressure and Hypertension Studies
- Fatty Acid Research and Health
Tokushima University
2012-2022
St. Michael's Hospital
2015-2019
University of Toronto
2015-2019
Sunnybrook Health Science Centre
2015
Engelhardt Institute of Molecular Biology
2015
Lomonosov Moscow State University
2015
Max Planck Institute for Heart and Lung Research
2015
Princess Margaret Cancer Centre
2015
Background and Purpose— Subarachnoid hemorrhage (SAH) is a complex stroke subtype characterized by an initial brain injury, followed delayed cerebrovascular constriction ischemia. Current therapeutic strategies nonselectively curtail exacerbated constriction, which necessarily disrupts the essential protective process of cerebral blood flow autoregulation. This study identifies smooth muscle cell autocrine/paracrine signaling network that augments myogenic tone in murine model experimental...
Heart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between artery cystic fibrosis transmembrane conductance regulator (CFTR) expression altered cerebrovascular reactivity in HF SAH. In SAH, CFTR corrector compounds (C18 or lumacaftor) normalize pathological alterations expression, vascular reactivity, without affecting systemic hemodynamic parameters. normalization...
High mobility group box 1 (HMGB1) elevation after cerebral ischemia activates inflammatory pathways via receptors such as the receptor for advanced glycation end products (RAGE) and toll-like (TLRs) leads to brain damage. Eicosapentaenoic acid (EPA), a peroxisome proliferator-activated gamma (PPARγ) agonist, attenuates postischemic inflammation damage in male animals. However, HMGB1 signaling effects of EPA on ovariectomized (OVX(+)) rats remain unclear. We hypothesized that OVX(+)...
The incidence of cerebral aneurysms is higher in women than men, especially postmenopause. Although hypertension thought to be associated with a high stroke, not all patients unruptured are hypertensive. possibility water-free Na + storage has been raised. However, whether the increase body /water ratio that characterizes accumulation formation remains obscure. To examine this relationship, Sprague-Dawley female rats subjected carotid artery ligation were divided into 3 groups: high-salt...
Cerebral ischemia triggers inflammatory changes, and early complications unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment various cell types to ischemic area. Although anti-inflammatory M2-type macrophages are thought exert protective effects against cerebral ischemia, little has been clarified regarding significance post-ischemic phase-dependent modulation macrophages. To test our hypothesis that represents a potential therapy damage, on rats an...
Cancers in adolescents and young adults (AYAs) (age 15-39 years) often present with unique characteristics poor outcomes. To date, spinal cord glioblastoma, a rare tumor, remains poorly understood across all age groups, including AYAs. This comparative study aimed to investigate the clinical outcomes of glioblastoma AYAs older 40-74 years), given limited availability studies focusing on
Background and Purpose: Peripheral macrophages include M1- M2 macrophages; they produce pro-inflammatory anti-inflammatory cytokines, respectively. Inflammation produces group-specific component protein-derived macrophage activating factor (GcMAF). The role of activated by GcMAF in the post-ischemic brain remains unclear. We hypothesized that after ischemia is time-dependently different dominant activation facilitates repair. Methods: After subjecting 7-week-old male Wistar rats to 2-hr...
Background and Purpose— Neuroprotection after ischemia by pretreatment with a peroxisome proliferator-activated receptor gamma (PPARγ) agonist was associated the transcriptional activation of anti-apoptotic- survival genes via p-STAT3 in oophorectomized (OVX) rats. Based on this finding, we hypothesized that post-stroke PPARγ contributes to neurogenesis. Methods— To examine proliferation differentiation cerebral innate- bone marrow (BM)-derived stem cells, treated 13 week-old OVX Wistar rats...
Background and Purpose— Cerebral ischemia triggers the acute inflammation that has been associated with an increase in brain damage. In male rats exposed to ischemic insult, high-mobility group protein box-1 (HMGB1) activates inflammatory pathways via its receptor for advanced glycation products (RAGE) toll-like receptors (TLRs). We examined role of these molecules female experimental further investigated efficacy eicosapentaenoic acid (EPA) against cerebral effect on HMGB1 signaling....
Background and Purpose— Hypertension is thought to be associated with a high incidence of stroke. However, not all patients unruptured cerebral aneurysms are hypertensive. In the DOCA-salt rats increase in body water-free Na+ storage hypertension suggested. We hypothesized that oophorectomized fed salt diet, accumulation may increased, leading formation aneurysms. To address relationship between Na+-to-water ratio characterizes aneurysms, we focused on vascular Na efflux pump Na+/K+ ATPase....
Abstract Background Cerebral ischemia triggers inflammatory changes, and early complications unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment various cell types to ischemic area. Although phenotype-specific monocytes/macrophages appear play a role, detailed effects remain unclear. To test our hypothesis that post-ischemic phase-dependent modulation macrophages may represent potential therapy against damage, we studied significance inducing...