A5059284202- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Respiratory Support and Mechanisms
- Cholesterol and Lipid Metabolism
- Congenital Anomalies and Fetal Surgery
- Breastfeeding Practices and Influences
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Protein Hydrolysis and Bioactive Peptides
- Seed and Plant Biochemistry
- Clinical Nutrition and Gastroenterology
- Muscle metabolism and nutrition
- Neuroscience of respiration and sleep
Maastricht University
2018-2024
Chorioamnionitis, clinically most frequently associated with Ureaplasma, is linked to intestinal inflammation and subsequent gut injury. No treatment available prevent chorioamnionitis-driven adverse outcomes. Evidence increasing that plant sterols possess immune-modulatory properties. Therefore, we investigated the potential therapeutic effects of in lambs intra-amniotically (IA) exposed Ureaplasma. Fetal were IA Ureaplasma parvum (U. parvum, UP) for six days from 127 d–133 d gestational...
Chorioamnionitis, an important cause of preterm birth, is linked to necrotizing enterocolitis (NEC). NEC characterized by a disrupted mucus barrier, goblet cell loss, and endoplasmic reticulum (ER) stress the intestinal epithelium. These findings prompted us investigate mechanisms underlying alterations over time in ovine chorioamnionitis model. Fetal lambs were intra-amniotically (IA) exposed lipopolysaccharides (LPS) for 5, 12, or 24 h, 2, 4, 8, 15 d before premature delivery at 125...
Many whey proteins, peptides and protein-derived amino acids have been suggested to improve gut health through their anti-oxidant, anti-microbial, barrier-protective immune-modulating effects. Interestingly, although the degree of hydrolysis influences peptide composition and, thereby, biological function, this important aspect is often overlooked. In current study, we aimed investigate effects protein fractions with different degrees enzymatic on intestinal epithelium in disease a novel 2D...
Disruption of the intestinal mucus barrier and epithelial endoplasmic reticulum (ER) stress contribute to necrotizing enterocolitis (NEC). Previously, we observed goblet cell loss increased ER following chorioamnionitis. Here, investigated how chorioamnionitis affects cells by assessing their cellular characteristics. Importantly, features are compared with those in clinical NEC biopsies. Mucus thickness was assessed as read-out function. Fetal lambs were intra-amniotically (IA) infected for...
Perinatal inflammation increases the risk for bronchopulmonary dysplasia in preterm neonates, but underlying pathophysiological mechanisms remain largely unknown. Given their anti-inflammatory and regenerative capacity, multipotent adult progenitor cells (MAPC) are a promising cell-based therapy to prevent and/or treat negative pulmonary consequences of perinatal neonate. Therefore, pathophysiology adverse lung outcomes following benefits MAPC treatment at interface prenatal inflammatory...
Chorioamnionitis is a risk factor for necrotizing enterocolitis (NEC). Ureaplasma parvum (UP) clinically the most isolated microorganism in chorioamnionitis, but its pathogenicity remains debated. associated with ileal barrier changes, colonic alterations, including those of mucus barrier, remain under-investigated, despite their importance NEC pathophysiology. Therefore, this study, hypothesis that antenatal UP exposure disturbs integrity, thereby potentially contributing to pathogenesis,...
Preterm infants close to viability commonly require mechanical ventilation (MV) for respiratory distress syndrome. Despite used lung-sparing techniques, rapid lung expansion during MV induces injury, a risk factor bronchopulmonary dysplasia. This study investigates whether with optimized is feasible and it can further minimize injury. Therefore, (OLEV) was compared conventional volume targeted ventilation.