A5103235058- Escherichia coli research studies
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Veterinary medicine and infectious diseases
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Cannabis and Cannabinoid Research
- CRISPR and Genetic Engineering
- Cancer Research and Treatments
- Herpesvirus Infections and Treatments
- Lung Cancer Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Salmonella and Campylobacter epidemiology
- Glycosylation and Glycoproteins Research
- Animal Virus Infections Studies
- Galectins and Cancer Biology
- Nitric Oxide and Endothelin Effects
Army Medical University
2012-2024
Alimera Sciences (United States)
2024
Southwest Hospital
2016-2019
Highlights•F. nucleatum infection is enriched in CRC tissues with metastasis•F. promotes cell metastasis to the liver and lung mouse models•EVADR induced by F. increases metastasis•EVADR interacts YBX1 enhance translation of EMT-related factorsSummaryBoth Fusobacterium (F. nucleatum) long non-coding RNA (lncRNA) EVADR are associated colorectal cancer (CRC), but their relationship mechanisms which poorly understood. Here, we report that it can be detected CRC-metastasis colonization models....
Toll-like receptors (TLRs) 2 and 4 play critical roles in intestinal inflammation caused by Fusobacterium nucleatum (F. nucleatum) infection, but the role of TLR2/TLR4 regulation proinflammatory cytokines remains unknown. In this study, through microarray analysis qRT-PCR, we showed that are involved F. nucleatum-induced inflammatory signaling pathway Caco-2 cells, C57BL/6 mice human clinical specimens. TLR2-/- TLR4-/- mice, infection resulted increased colonization bacteria production IL-8,...
Fusobacterium nucleatum (F. nucleatum) plays a critical role in gastrointestinal inflammation. However, the exact mechanism by which F. contributes to inflammation is unclear. In present study, it was revealed that could induce production of proinflammatory cytokines (IL-8, IL-1β and TNF-α) reactive oxygen species (ROS) Caco-2 colorectal) adenocarcinoma cells. Furthermore, ROS scavengers (NAC or Tiron) decrease during infection. addition, we observed autophagy impaired cells after The...
Colorectal cancer (CRC) is a common and highly lethal form of cancer. Although the etiologic role Fusobacterium nucleatum (F. nucleatum) in development CRC has been elucidated, specific tumor molecules involved progression induced by F. have not identified. This study investigated several miRNAs genes nucleatum-induced Affymetrix miRNA microarray technology GeneChip Human Transcriptome Array 2.0. The results suggest that miR-4474 miR-4717 are up-regulated tissues response to infection,...
T492I, a mutation encountered in SARS-CoV-2 nonstructural protein 4 (NSP4), enhances viral replication and alters cleavage, causing potential evolutionary impacts. Through comprehensive comparative analyses based on evolve-and-resequence experiments of wild-type Delta strains with or without we demonstrate that NSP4 T492I not only increases the rate, but also accelerates emergence many mutations characteristic for Omicron variants. Accordingly, populations evolved from ancestors show...
As a principal ingredient of vaccines, adjuvants can directly induce or enhance the powerful, widespread, innate, and adaptive immune responses associated with antigens. Ophiopogonin D (OP-D), purified component extracted from plant Ophiopogon japonicus, has been found to be useful as vaccine adjuvant. The problems low solubility toxicity OP-D effectively overcome by using low-energy emulsification method prepare nanoemulsion ophiopogonin (NOD). In this article, series in vitro protocols for...
Helicobacter pylori infect nearly half of the world’s population and are associated with a spectrum gastric maladies. The cytotoxin-associated gene pathogenicity island (cag PAI) encoding type IV secretion system (T4SS) has been implicated in series host responses during infection. The cag PAI contains about 28 - 30 open-reading frames, for most which exact function is not well characterized or totally unknown delivered effector, CagA that becomes tyrosine phosphorylated upon delivery into...
Backgrounds Enterohaemorrhagic E. coli (EHEC) O157:H7 is a primary food‐borne bacterial pathogen capable of posing serious challenge to the public health worldwide. EspA ( secreted protein A) plays an important role in attaching/effacing lesion. Determination epitopes will be facilitate understanding multipler pathogenicity as well developing vaccine anainst O157:H7. Methods Anti‐EspA mAbs were produced by hybridoma technique. Epitope mapping was carried out truncated immuno‐blotting with...
Both F. nucleatum and long non-coding RNA (lncRNA) EVADR are associated with colorectal cancer (CRC), but their relationship CRC metastasis the mechanisms by which promotes poorly understood. Here, we report that promoted cell to liver lung, it traveled primary tumor cells metastatic sites. Furthermore, upregulated expression of EVADR, can increase ability in vivo vitro . Mechanistically, elevated served as a modular scaffold for YBX1 directly enhance translation epithelial-mesenchymal...