A5080466143- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Disaster Response and Management
- COVID-19 epidemiological studies
- Migration, Health and Trauma
- Intensive Care Unit Cognitive Disorders
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Tuberculosis
- Parvovirus B19 Infection Studies
- Antibiotic Use and Resistance
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Pharmaceutical Quality and Counterfeiting
- Heme Oxygenase-1 and Carbon Monoxide
- Lung Cancer Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Infectious Diseases and Mycology
- Coronary Artery Anomalies
- Retinal and Optic Conditions
Genomics (United Kingdom)
2022-2023
UK Health Security Agency
2022-2023
University College London
2014-2023
University College Hospital
2023
Barts Health NHS Trust
2018-2021
Public Health England
2020-2021
OG Technologies (United States)
2021
University of Oxford
2021
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2021
University of Liverpool
2009-2021
ABSTRACT Background There is an urgent need to better understand whether individuals who have recovered from COVID-19 are protected future SARS-CoV-2 infection. Methods A large multi-centre prospective cohort was recruited publicly funded hospital staff in the UK. Participants attended regular PCR and antibody testing (every 2-4 weeks) completed fortnightly questionnaires on symptoms exposures. At enrolment, participants were assigned either positive (antibody or prior PCR/antibody test...
Background: There is an urgent need to better understand whether individuals who have recovered from COVID-19 are protected future SARS-CoV-2 infection.Methods: A large multi-centre prospective cohort was recruited publicly funded hospital staff in the UK. Participants attended regular PCR and antibody testing (every 2-4 weeks) completed fortnightly questionnaires on symptoms exposures. At enrolment, participants were assigned either positive (antibody or prior PCR/antibody test positive)...
Abstract COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these are administered as combinations e.g. casirivimab+imdevimab or, for targeting relatively conserved regions, individually sotrovimab. Unprecedented genomic surveillance SARS-CoV-2 in the UK has enabled a genome-first approach to detect emerging drug resistance Delta and Omicron cases sotrovimab respectively. Mutations occur...
Introduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous COVID-19 is essential to inform ongoing management pandemic. This study aims determine whether prior or vaccination in healthcare workers protects future infection. Methods analysis a prospective cohort design staff members working hospitals UK. At enrolment, participants are allocated into cohorts, positive naïve, dependent on their status, as measured standardised...
There are concerns that sotrovimab has reduced efficacy at reducing hospitalisation risk against the BA.2 sub-lineage of Omicron SARS-CoV-2 variant. We performed a retrospective cohort (n = 8850) study individuals treated with in community, objective assessing whether there were any differences cases compared BA.1. estimated hazard ratio hospital admission length stay 2 days or more was 1.17 for BA.1 (95%CI 0.74-1.86). These results suggest similar between two sub-lineages.
Cytoglobin (Cygb) was first described in 2002 as an intracellular globin of unknown function. We have previously shown the downregulation cytoglobin a key event familial cancer syndrome upper aerodigestive tract.Cytoglobin expression and promoter methylation were investigated sporadic head neck squamous cell carcinoma (HNSCC) using cross-section clinical samples. Additionally, putative mechanisms Cygb explored by subjecting HNSCC lines to hypoxic culture conditions 5-aza-2-deoxycitidine...
Six lineages of Mycobacterium tuberculosis sensu stricto (which excludes M . africanum) are described. Single-country or small observational data suggest differences in clinical phenotype between lineages. We present strain lineage and from 12,246 patients 3 low-incidence 5 high-incidence countries. used multivariable logistic regression to explore the effect on site disease cavities chest radiography, given pulmonary TB; multinomial investigate types extra-pulmonary TB, lineage; accelerated...
The human and financial costs of disasters are vast. In 2011, were estimated to have cost $378 billion worldwide; affected 64% the world's population since 1992. Consequently, disaster risk reduction strategies become increasingly prominent on national international policy agendas. However, function health in often has been restricted emergency response. To mitigate effect social development goals (such as Millennium Development Goals) increase resilience among at-risk populations, should...
Abstract Objectives Sotrovimab is one of several therapeutic agents that have been licensed to treat people at risk severe outcomes following COVID-19 infection. However, there are concerns it has reduced efficacy with the BA.2 sub-lineage Omicron (B.1.1.529) SARS-CoV-2 variant. We compared individuals BA.1 or variant treated in community assess their hospital admission. Methods performed a retrospective cohort study and either had classification. Results Using Stratified Cox regression...
Ebola virus disease (EVD) was first discovered in the Democratic Republic of Congo 1976, and by 2013 had caused approximately 20 recorded outbreaks across East Central Africa. These been restricted to rural areas confined small clusters villages. In each case containment achieved within a few months after fewer than 500 confirmed cases. The world assumed that EVD too efficient at killing its hosts, doomed quickly burn out wherever it arose. 2014 West African outbreak has changed everything....
Abstract Eight lineages of Mycobacterium tuberculosis sensu stricto are described. Single-country or small observational data suggest differences in clinical phenotype between lineages. We present strain lineage and from 12,246 patients 3 low-incidence 5 high-incidence countries. used multivariable logistic regression to explore the effect on site disease cavities chest radiography, given pulmonary TB; multinomial investigate types extra-pulmonary TB, lineage; accelerated failure time Cox...
Abstract Background The overall risk of reinfection in individuals who have previously had COVID-19 is unknown. To determine if prior SARS-CoV-2 infection (as determined by at least one positive commercial antibody test performed a laboratory) healthcare workers confers future immunity to reinfection, we are undertaking large-scale prospective longitudinal cohort study staff across the United Kingdom. Methods Population and Setting: members organisations working hospitals UK At recruitment,...
Abstract The COVID-19 pandemic saw unprecedented resources and funds driven into research for the development, subsequent rapid distribution, of vaccines, diagnostics directly acting antivirals (DAAs). DAAs have undeniably prevented progression life-threatening conditions in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, there are concerns antimicrobial resistance (AMR), antiviral specifically, DAAs. To preserve activity therapy, as well detect...
Background Understanding how pathogen genetic factors contribute to pathology in TB could enable tailored treatments the most pathogenic and infectious strains. New strategies are needed control drug-resistant TB, which requires longer costlier treatment. We hypothesised that severity of radiological on chest radiograph disease was associated with variants arising independently, multiple times (homoplasies) Mycobacterium tuberculosis genome. Methods performed whole genome sequencing...
Summary Some COVID-19 patients are unable to clear their infection or at risk of severe disease, requiring treatment with neutralising monoclonal antibodies (nmAb) and/or antivirals. The rapid roll-out novel therapeutics means there is limited understanding the likely genetic barrier drug resistance. Unprecedented genomic surveillance SARS-CoV-2 in UK has enabled a genome-first approach detection emerging Here we report accrual mutations Delta and Omicron cases treated casirivimab+imdevimab...