A5102016703- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Gastric Cancer Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Spondyloarthritis Studies and Treatments
- Tuberculosis Research and Epidemiology
- Rheumatoid Arthritis Research and Therapies
- Ion channel regulation and function
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Diseases and Tuberculosis
- Cardiac Arrest and Resuscitation
- Cancer, Lipids, and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Porphyrin Metabolism and Disorders
- Aortic Disease and Treatment Approaches
- Healthcare Education and Workforce Issues
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Thyroid Disorders and Treatments
- Eosinophilic Esophagitis
- Appendicitis Diagnosis and Management
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
Hanyang University
2009-2025
Biostatistical Consulting (United States)
2019-2023
Kyung Hee University
2011
Abstract There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than those without bronchiectasis. Using 2005–2015 from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause cohort relative to matched cohort. The effect of comorbidities over study period on was also assessed. All-cause significantly (2505/100,000 vs 2142/100,000 person-years, respectively; P < 0.001). Mortality...
The aim of this study is to examine the impact tumor necrosis factor inhibitors (TNFI) on nontuberculous mycobacterium (NTM) infection in rheumatoid arthritis (RA) patients a tuberculosis (MTB) endemic area. We selected 1089 TNFI-treated RA and 4356 untreated using propensity-matching analysis according age, gender, Charlson comorbidity index Korean National Health Insurance Service database from July 2009 December 2010. Both groups were followed-up until end 2016 measure incidence...
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) has the potential to improve neurological outcomes in patients with refractory out-of-hospital cardiac arrest (OHCA), offering an alternative conventional (CCPR). However, its effectiveness OHCA remains controversial despite advancements techniques. Methods: This retrospective single-center study compared and 30-day survival between ECPR CCPR from January 2014 2022. Patients aged 18–75 witnessed OHCA, minimal no flow low times,...
This study aimed to evaluate the prognostic impact of permanent pacemaker (PPM) implantation within first year after mitral valve (MV) surgery combined with Cox-maze procedure, focusing on long-term outcomes, including overall mortality, infective endocarditis (IE) and ischaemic stroke. We conducted a retrospective cohort using data from National Health Insurance Service (NHIS) in South Korea, identifying 10 127 patients who underwent MV procedure between 2005 2020. Patients were classified...
Background/Objectives: We sought to evaluate the association between risk of papillary thyroid carcinoma (PTC) and single-nucleotide polymorphisms (SNPs) breast cancer genes 1 (BRCA1) 2 (BRCA2). Methods: prospectively recruited 515 cases with PTC 296 controls without cancer. The genotypes five BRCA1 SNPs (rs8176318, rs1799966, rs799917, rs16940, rs1799949) three BRCA2 (rs15869, rs1799943, rs1799955) were determined using TaqMan assay. evaluated haplotypes due linkage disequilibrium (LD)....
Abstract Background Emergence delirium is well known as early postoperative behavioral change after general anesthesia. However, it unclear whether children with emergence have negative changes hospital discharge. Aim This observational study investigated the association between and posthospital changes. Methods One‐hundred preschoolers aged 2–7 years undergoing elective surgery were enrolled in 2 tertiary university hospitals. Preoperative anxiety level was assessed using modified Yale...
We investigated the neuroprotective effect and mechanisms of action cilnidipine, a long-acting, second-generation 1,4-dihydropyridine inhibitor L- N-type calcium channels, in PC12 cells that were neuronally differentiated by treatment with nerve growth factor (nPC12 cells). To evaluate cilnidipine on viability, nPC12 treated several concentrations this drug before performing viability assays. Free radical levels intracellular signaling proteins measured fluorescent probe,...
The objective of this study was to investigate spinal radiographic progression in specific age ranges ankylosing spondylitis (AS) patients.
Various approaches are required to prevent and treat heterogeneity-based prostate cancer. Here, we analyzed the anticancer effects of metformin, which has a good toxicity profile is inexpensive.From January 2010 December 2019, analysis was conducted retrospectively in cohort from National Health Insurance Service database. The wash-out period set for cancer diagnosis 2011, subjects (105,279) diagnosed with (ICD C61) 2012 2014 were excluded final (105,216) defined as metformin administration...
Objectives This study aimed to investigate the effect of rapid weight gain (RWG) on incidence central precocious puberty (CPP) using nationwide population-based data. Methods A total 253,967 children (101,841 boys and 152,126 girls) who underwent regular health consultations under National Health Insurance Service from 2007 2010 were followed up until age 10 years for 9 girls. We calculated differences in Z-scores 4–6 months 9–12 (infancy) 18–24 or 30–36 (toddlerhood) lambda-mu-sigma method....
Neurodevelopmental disorder (NDD) in preterm infants has become of great interest. We aimed to investigate the impact birth on proportion NDD using nationwide data provided by Korean National Health Insurance Service. included 4894 extremely or low-birth-weight (EP/ELBW; <28 weeks gestation weight < 1000 g) infants, 70,583 other (OP/LBW; 28−36 2500 and 264,057 full-term born between 2008 2015. observed their neurodevelopment until 6 years age year 2019, whichever occurred first. Diagnoses...
Mucinous breast carcinoma (MBC) is a rare type of cancer. Although patients with MBC may have better prognosis than that invasive ductal carcinoma, many clinicians administer adjuvant chemotherapy regimens similar to those for other tumors. Using data from nationwide clinical database, this study evaluated the significance systemic and whether it can be omitted in patients.We included 3,076 diagnosis recorded Korean Breast Cancer Registry between January 1990 August 2016. We used...
Background: Neuron-specific enolase (NSE) has traditionally been used as a biomarker to predict neurologic outcomes after cardiac arrest. This study aimed evaluate the utility of NSE in predicting patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). Methods: observational cohort included 47 consecutive adult ECPR (median age, 59.0 years; 74.5% males) treated between January 2018 and December 2021 at tertiary life support center. The primary outcome was poor outcome,...
ABSTRACT Introduction Helicobacter pylori infects over 50% of the global population, prompting issuance guidelines for effective diagnosis and treatment. However, research on guideline dissemination adherence is limited. Therefore, we assessed nationwide status H. eradication therapies in Korea before after updates. Methods Using data from Korean National Health Insurance Service, this retrospective cohort study analyzed changes across three periods: Phase I (2006–2007), II (2014–2015), III...
This study aimed to analyze pregnancy outcomes based on biologic agents use in women using the nationwide population-based database.
To assess the efficacy and safety of intra-articular sacroiliac glucocorticoid injection in ankylosing spondylitis (AS).Patients with AS undergoing fluoroscopy-guided were enrolled between 2012 2018. Efficacy was assessed by numeric pain rating scale, acute phase reactants, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Functional Index, Score (ASDAS). Patients who started biologics within 3 months despite intervention compared those not starting biologics, hence: nonbiologic...
Abstract Colorectal cancer is the third leading cause of cancer-related death in Western countries. Chemotherapeutic agents with different mechanisms action have shown an increase cure rates. In present study, we investigated effect a combination low concentration paclitaxel (taxol, 5 nM) and topoisomerase 1 inhibitor camptothecin (CPT) on HCT116 colon cells. Although viability cells treated taxol alone was similar to that control cells, sequential treatment CPT exhibited high cytotoxicity....
The meta-evaluation of dental education evaluation and accreditation was conceptualized as 'evaluating the system' in order to improve quality evaluation. In perform accreditation, which seeks improvement directions by comprehensively systematically evaluating analyzing development criteria should be preceded. purpose this study is redefine direction establish improve-ment plans developing for confirming its validity. study, sub-evaluation system Korean Institute Dental Education Evaluation...