A5101462863- Marine Ecology and Invasive Species
- Plant-derived Lignans Synthesis and Bioactivity
- Marine Biology and Environmental Chemistry
- Enzyme Catalysis and Immobilization
- Bioactive Natural Diterpenoids Research
- Identification and Quantification in Food
- Phytochemical compounds biological activities
- Cancer Mechanisms and Therapy
- Signaling Pathways in Disease
- Vibrio bacteria research studies
- Multicomponent Synthesis of Heterocycles
- Renal and related cancers
- Gastric Cancer Management and Outcomes
- Environmental Toxicology and Ecotoxicology
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Redox biology and oxidative stress
- Environmental DNA in Biodiversity Studies
- Microplastics and Plastic Pollution
- Autophagy in Disease and Therapy
- Medicinal Plants and Neuroprotection
- Analytical Chemistry and Chromatography
- Heat shock proteins research
- Meat and Animal Product Quality
- Research on Leishmaniasis Studies
Soochow University
2025
Huazhong Agricultural University
2012-2024
Harbin Engineering University
2020-2024
China Agricultural University
2024
Nanjing University
2022
Nanjing General Hospital of Nanjing Military Command
2022
Northwest A&F University
2018-2021
Shanghai University
2021
Shanghai University of Traditional Chinese Medicine
2021
Jilin University
2017-2018
Future therapeutic applications of differentiated human embryonic stem cells (hESC) carry a risk teratoma formation by contaminating undifferentiated hESC. We generated 10 monoclonal antibodies (mAbs) against surface antigens hESC, showing strong reactivity undifferentiated, but not The mAbs did cross react with mouse fibroblasts and showed weak to no embryonal carcinoma cells. Notably, one antibody (mAb 84) is cytotoxic hESC NCCIT in concentration-dependent, complement-independent manner....
Arctigenin (ARG) has been previously reported to exert high biological activities including anti-inflammatory, antiviral and anticancer. In this study, the anti-tumor mechanism of ARG towards human hepatocellular carcinoma (HCC) was firstly investigated. We demonstrated that could induce apoptosis in Hep G2 SMMC7721 cells but not normal hepatic cells, its apoptotic effect on stronger than SMMC7721. Furthermore, following study showed treatment led a loss mitochondrial out membrane potential,...
Arctigenin (ARG) has been reported to be a bioactive lignan from Arctium lappa exerting various activities including anti-cancer and immune-regulation. The present study aimed investigate the anti-metastasis activity mechanism of ARG against hepatocellular carcinoma in vitro vivo. results showed that exhibited significant cytotoxicity on Hep G2 SMMC 7721 cells (but not normal liver LO2). In addition, migration invasion were also remarkably repressed. Furthermore, attenuated Wnt/β-catenin...
Apolipoprotein M (ApoM), a protein component of lipoproteins, is closely related to the development atherosclerosis, but specific mechanism remains elusive. Mitochondrial DNA damage can contribute so this study was designed investigate whether ApoM influences structure and function mitochondria during progression atherosclerosis explore underlying mechanism. Atherosclerosis models were established in male ApoM-deficient (ApoM-/- ) wild-type (ApoM+/+ C57BL/6 mice fed high-fat diet (HFD),...
Arctigenin (ARG) has been proved to inhibit the viability of hepatocellular carcinoma (HCC) via inducing apoptosis. However, precise mechanism remains unknown. The present study was aimed further investigate ARG against HCC in vitro and vivo.Arctigenin applied vivo. Western blotting, immunohistochemistry, etc., were used mechanisms.The time-dependent enhancement Bax/Bcl-2 ratio, cytochrome c release, Fas FasL levels, caspase cascade activation loss mitochondrial out membrane potential...
Pin1 isomerizes the phosphorylated Ser/Thr-Pro peptide bonds and regulates functions of its binding proteins by inducing conformational changes. Involvement in aging process has been suggested based on phenotype Pin1-knockout mice interaction with lifespan regulator protein, p66Shc. In this study, we utilize a proteomic approach identify peroxiredoxin 1 (PRDX1), another aging, as novel protein. binds to PRDX1 through interacting phospho-Thr90-Pro91 motif PRDX1, is abolished when Thr90...
Arctigenin (ARG), one of the most active ingredients abstracted from seeds Arctium lappa L., has been proved to exert promising biological activities such as immunomodulatory, anti-viral, and anti-cancer etc. However, mechanism behind its immunomodulatory function still remains elusive be further investigated. In this study, we found that ARG had no significant effects on cell proliferation in both porcine alveolar macrophage line (3D4/21) primary derived macrophage. It remarkably increased...
A nano-biocatalyst has been successfully prepared via coordination between zinc ion and the nitrogen atoms of amide groups in Candida sp. 99-125 lipase. The as-prepared nanoparticle an excellent hierarchical structure with a large number separate petals. In regioselective acylation arbutin, showed enhanced enzyme activities to about 4.3-folds than free enzyme. Meanwhile, exhibited good operational reusability only 6% activity lost during 10 continuous reaction-recycles.
Fructus arctii is commonly used in Chinese medicine, and arctiin arctigenin are its main active ingredients. Arctiin has low bioavailability the human body needs to be converted into by intestinal microbes before it can absorbed blood. Arctigenin antiviral, anti-inflammatory, anti-tumour effects development important value. In this study, we external microbial fermentation with Aspergillus awamori Trichoderma reesei process convert from F. powder arctigenin, hence increasing bioavailability....
Ballast water has a negative impact on marine environment; the existing combined ultraviolet (UV) filtration system that for treating ballast relatively low effective rate and instability in inactivating microorganisms. In this study, established high gradient magnetic separation-ultraviolet photocatalysis (HGMS-UV/TiO 2 ) was taken, back propagation (BP) neural network TracePro used to simulate analyse UV field intensity optimizing. Further experimental verification carried out with...
Oxidative stress-induced chondrocyte apoptosis and degradation of the extracellular matrix (ECM) play an important role in progression osteoarthritis (OA). In addition, tert-butylhydroquinone (TBHQ) is activator nuclear factor erythroid derived-2-related 2 (Nrf2). The present study aimed to determine effectiveness TBHQ preventing chondrocytes matrix, induced by oxidative stress, vitro. Therefore, rat were exposed 20 μM tert-butyl hydroperoxide (TBHP) for 24 h establish damage model,...
Ballast Water Treatment System (BWTS) is a system designed to remove biological organisms from ballast water. However, the existing BWTSs often have problems in practical applications. In this study, multiwave ultraviolet (UV)-modified TiO 2 photocatalyst inactivation (longwave UV, UVA+shortwave UVC+vacuum VUV/Cu-N-TiO ) for microorganism water was established. The results showed that UVA+UVC+VUV/Cu-N-TiO improved UV light quantum yield and catalyst activity photocatalytic reaction fully...
To study the pharmacokinetic process of Danshensu in cerebal ischemia injury model rats and correlation with its anti-cerebral effect. In this study, middle cerebral artery occlusion (MCAO) was established, which all were intravenously injected at a single dose 40 mg x kg(-1). The HPLC-DAD method applied to determine plasma concentration different time points draw drug-time curve. Meanwhile, superoxide dismutase (SOD) lactate dehydrogenase (LDH) activity determined time-effect DAS 3.2. 6...
ABSTRACT In this study, modified Fe3O4@SiO2@PAC magnetic seeds were prepared to explore the separation efficiency and mechanism of algae particles in high-turbidity ballast water under different influencing factors. The results showed that when mass ratio Fe3O4@SiO2 PAC was 1:3, removal rate turbidity increased by 20 15.7% compared with unmodified seed. When dosage seed 217.5 mg/L, stirring time 129.2 s, speed 211.6 r/min, pH 8, rates 83.23 97.85%, respectively. secondary after compounding...