A5100358530- Optical Coherence Tomography Applications
- Cardiac Imaging and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Polarization and Ellipsometry
- Solid State Laser Technologies
- Medical Imaging Techniques and Applications
- Calibration and Measurement Techniques
- Spectroscopy and Chemometric Analyses
- Radiomics and Machine Learning in Medical Imaging
- Infrared Thermography in Medicine
- Advanced Fiber Laser Technologies
- Photorefractive and Nonlinear Optics
- Radiation Dose and Imaging
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Cell Image Analysis Techniques
- Multiple and Secondary Primary Cancers
Sinovac Biotech
2025
Soochow University
2025
Beijing Institute of Technology
2021-2024
Leibniz Institute of Photonic Technology
2024
China Aerodynamics Research and Development Center
2024
Guangxi University
2024
Zhejiang Normal University
2024
Shanghai First People's Hospital
2023
Shanghai Jiao Tong University
2023
Hohai University
2022
Intraoperative imaging of tumor microenvironment reveals correlations between extracellular vesicle density and breast pathology.
We report an automated differentiation model for classifying malignant tumor, fibro-adipose, and stroma in human breast tissues based on polarization-sensitive optical coherence tomography (PS-OCT). A total of 720 PS-OCT images from 72 sites 41 patients with H&E histology-confirmed diagnoses as the gold standard were employed this study. The is trained by features extracted both one OCT-based metric (i.e., intensity) four PS-OCT-based metrics phase difference between two channels ( PD ),...
We report the development and implementation of an intraoperative polarization-sensitive optical coherence tomography (PS-OCT) system for enhancing breast cancer detection. A total 3440 PS-OCT images were intraoperatively acquired from 9 human specimens diagnosed by H&E histology as healthy fibro-adipose tissue (n = 2), stroma or invasive ductal carcinoma (IDC, n 5). standard OCT-based metric (coefficient variation (CV)) PS-OCT-based metrics sensitive to biological birefringence (i.e.,...
Background: The previous study assessed the immune durability of Sabin strain inactivated poliovirus vaccine (sIPV) at four years age; an update on its long-term persistence is warranted. Methods: This Phase IV, open-label, parallel-controlled observational study, required by China's NMPA, involves 6.5-year-olds who received doses sIPV or wIPV 2, 3, 4, and 18 months during III trial. Participants are recruited in a 2:1 ratio contribute blood samples for neutralizing antibody (nAb) assays to...
Objective Major adverse cardiovascular events (MACE) still occur in the normal left ventricular ejection fraction (LVEF) patients with coronary artery disease (CAD). Currently, there are no studies related to prognostic value of diastolic dyssynchrony (LVDD) combination perfusion, systolic dyssynchrony, and risk factors LVEF. Therefore, we aimed investigate incremental LVDD LVEF establish a model predict MACE. Methods This study included 239 suspected or known CAD who underwent gated...
Background: The previous study assessed the immune durability of Sabin strain inactivated poliovirus vaccine (sIPV) at four years age; an update on its long-term persistence is warranted. Methods: This Phase IV, open-label, parallel-controlled observational study, required by China’s National Medical Products Administration (NMPA), involves 6.5-year-old children who received doses sIPV or Salk IPV (wIPV) 2, 3, 4, and 18 months during III trial. Participants are recruited in a 2:1 ratio...
We report the development and implementation of a unique integrated Mueller-matrix (MM) near-infrared (NIR) imaging point-wise diffuse reflectance (DR) spectroscopy technique for improving colonic cancer detection diagnosis. Point-wise MM DR spectra can be acquired from any suspicious tissue areas indicated by imaging. A total 30 paired specimens (normal vs. cancer) were measured using system. Polar decomposition algorithms are employed on images to derive three polarization metrics...
Polarization-sensitive optical coherence tomography (PS-OCT) is a high-resolution label-free biomedical imaging modality that sensitive to the microstructural architecture in tissue gives rise form birefringence, such as collagen or muscle fibers. To enable polarization sensitivity an OCT system, however, requires additional hardware and complexity. We developed deep-learning method synthesize PS-OCT images by training generative adversarial network (GAN) on intensity images. The synthesis...
Whilst radiotherapy (RT) is widely used for cancer treatment, radiodermatitis caused by RT one most common severe side effect affecting 95% patients. Accurate assessment and classification essential to adopt timely management monitoring, which all depend on reliable objective tools grading. We therefore, in this work, reported the development grading performance validation of a low-cost (∼2318.2 CNY) algorithms-based hyperspectral imaging (aHSI) system assessment. The aHSI was enabled...
Herein, a fluorescent probe BFO-HPS was developed for imaging the H2Sn dynamics of macrophage inflammatory regulation in bone homeostasis. The indicated advantages including large response scale, rapid response, steady optical performance various pH conditions, high selectivity, and good selectivity. showed dose-dependent fluorescence at 570 nm concentration with linear range from 0.1 to 100 µM, limit detection 0.11 quantitation 0.10 µM. Based on low cyto-toxicity, provided intracellular...
As the critical dynamic parameters for soil, an extensive examination of elastic modulus Ed and damping ratio λ in coarse-grained soil is significant theoretical practical importance. Currently, there a scarcity experimental equipment methods measuring soils. Moreover, studies examining influence relative density on these soils are largely absent. To investigate behavior under varying densities, number triaxial tests were conducted specific using DYNTTS type test apparatus. The findings...
Defocus aberration in optical systems, including coherence tomography (OCT) systems employing Gaussian illumination, gives rise to the well-known compromise between transverse resolution and depth-of-field. This results blurry images when out-of-focus, whilst other low-order aberrations (e.g., astigmatism, coma, etc.) present both OCT system biological samples further reduce image contrast. Computational adaptive optics (CAO) is a computed interferometric imaging technique that modifies...
Some women die despite the favorable prognosis of small breast cancers. Breast ultrasound features may reflect pathological and biological characteristics a tumor. This study aimed to explore whether could identify cancers with poor outcomes. retrospective examined confirmed size <20 mm diagnosed in our hospital between 02/2008 08/2019. Clinicopathological were compared alive deceased cancer patients. Survival was analyzed using Kaplan-Meier curves. Multivariable Cox proportional hazards...
Abstract Background This study aimed to determine the role of insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3), an N 6 ‐methyladinosine reader, in progression and distant metastasis breast cancer. Methods IGF2BP3 expression was assessed 152 pairs cancer adjacent normal tissue (ANT) by real‐time quantitative polymerase chain reaction 561 cases 163 ANT immunohistochemistry. Survival curves were estimated using Kaplan–Meier method then compared statistically log‐rank test. The...
To document the appearance of artifacts created by commonly encountered surgical conditions and instrumentation on optical coherence tomography (OCT) to compare these findings with histopathology.Ex vivo study.Five canine cadavers.Skin, subcutaneous fat, skeletal muscle, fascia samples were obtained from fresh cadavers. Blood pooling, hemostatic crushing, scalpel blade cut, monopolar electrosurgery, bipolar vessel sealing device, ultrasonic energy induced each tissue type. Each specimen was...
Micropatterning reduces variability and demonstrates that regenerating rod cells preferentially contact other retinal based on their region of origin.
Abstract In this report, we report on the implementation of compressive sensing (CS) and sparse sampling in polarization sensitive optical coherence tomography (PS-OCT) to reduce number B-scans (frames consisting an array A-scans, where each represents a single depth profile reflections) required for effective volumetric (3D dataset composed B-scans) PS-OCT measurements (i.e. OCT intensity, phase retardation) reconstruction. Sparse is achieved through randomization step sizes along slow-axis...
The target feature is sensitive to the aspect angle of SAR observation, making interpretation and recognition image difficult. information acquired from a certain partial incomplete, multi-aspect observations have potential improve performance in this aspect. Three topics fine description are discussed, they 3D extraction, optimum imaging strategy for anisotropic scatterers, scattering extraction. initial results real P band airborne circular (CSAR) data turn table show that encouraging...
We report a diode-pumped Nd:YVO4 laser emitting at 1074 nm, based on the 4 F 3/2-4 I 11/2 transition, generally used for 1064 nm emission. A power of 323 mW has been achieved in continuouswave (CW) operation with fiber-coupled diode 18.2 W 808 nm. Intracavity second-harmonic generation CW mode also demonstrated 18 537 by using LiB3O5 (LBO) nonlinear crystal.
We report on the development of a two-beveled-fiber polarized (TBFP) fiber-optic Raman probe coupled with ball lens for in vivo superficial epithelial measurements endoscopy. The two-beveled fibers positioned symmetrically along lens, synergy paired parallel-polarized polarizers integrated between and maximize signal excitation collection from epithelium where gastrointestinal (GI) precancer arises. Monte Carlo (MC) simulations two-layer tissue phantom experiments show that developed detects...