A5100318426- Viral Infections and Vectors
- Genomics and Phylogenetic Studies
- Aquaculture Nutrition and Growth
- Insect symbiosis and bacterial influences
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Neurological diseases and metabolism
- Crustacean biology and ecology
- Plant Pathogens and Fungal Diseases
- Neurobiology and Insect Physiology Research
- Microbial Community Ecology and Physiology
- Mosquito-borne diseases and control
- Prion Diseases and Protein Misfolding
- Insect behavior and control techniques
- Gout, Hyperuricemia, Uric Acid
- Peatlands and Wetlands Ecology
- Insect Utilization and Effects
- Animal Disease Management and Epidemiology
- Microbial Metabolism and Applications
- Immune responses and vaccinations
- Zoonotic diseases and public health
- Plant and animal studies
- Sepsis Diagnosis and Treatment
- Fungal Biology and Applications
Wuhan Institute of Virology
2018-2024
Chinese Academy of Sciences
2015-2024
University of Chinese Academy of Sciences
2016-2024
Hefei National Center for Physical Sciences at Nanoscale
2024
University of Science and Technology of China
2024
Institute of Genetics and Developmental Biology
2024
Kunshan Industrial Technology Research Institute
2024
Institute of Applied Ecology
2023
Institute of Microbiology
2014-2022
Institute of Hydrobiology
2018-2021
ABSTRACT Since its emergence in 2013, the H7N9 low-pathogenic avian influenza virus (LPAIV) has been circulating domestic poultry China, causing five waves of human infections. A novel highly pathogenic (HPAIV) variant possessing multiple basic amino acids at cleavage site hemagglutinin (HA) protein was first reported two cases infection January 2017. More seriously, those HPAIV variants have transmitted and caused outbreaks on farms eight provinces China. Herein, we demonstrate presence...
Significance Influenza A virus (IAV) is one of the most important human pathogens, and it crucial to understand its life cycle develop antiviral strategies. However, IAV uncoating, an essential step in viral infection, has remained incomprehensible. Here, via construction infectious virions encapsulating quantum dots, we tracked uncoating ribonucleoprotein complex (vRNP) dynamics single virions. Our results reveal that after fusion vRNP segments are released separately into cytosol,...
Genomic information is essential for taxonomic, phylogenetic, and functional studies to comprehensively decipher the characteristics of microorganisms, explore microbiomes through metagenomics, answer fundamental questions nature human life. However, large gaps remain in available genomic sequencing published bacterial archaeal species, are even larger fungal type strains. The Global Catalogue Microorganisms (GCM) leads an internationally coordinated effort sequence strains close maps...
The Zika virus (ZIKV) epidemic poses a substantial threat to the public, and development of safe effective vaccines is demanding challenge. In this study, we constructed kind self-assembling nanovaccine which confers complete protection against ZIKV infection. envelop protein domain III (zEDIII) was presented on recombinant human heavy chain ferritin (rHF) form zEDIII-rHF nanoparticle. Immunization mice with nanoparticle in absence an adjuvant induced robust humoral cellular immune...
Ebola virus (EBOV) causes severe hemorrhagic fever in humans with high mortality. In disease (EVD) survivors, EBOV persistence the eyes may break through inner blood–retinal barrier (iBRB), leading to ocular complications and EVD recurrence. However, mechanism by which affects iBRB remains unclear. Here, we used vitro model simulate retinal tissue found that virus-like particles (EBO-VLPs) could disrupt iBRB. Cytokine screening revealed EBO-VLPs stimulate pericytes secrete vascular...
Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar with propensity for invading hypothalamus, leading to devastating endocrine and metabolic disorders. Here, we developed two autochthonous animal models that faithfully recapitulate molecular pathology, clinical manifestations, transcriptomic profiles of papillary...
The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads wide spectrum clinical manifestations. Ocular abnormalities have been reported in association COVID-19, but nature impairments was not specified. Here, we report case female patient diagnosed glaucoma on re-hospitalization for ocular complications two months after being discharged...
To determine the variation of water quality in rice-crayfish (Procambarus clarkii) integrated systems (RCIS) China, eleven parameters were measured monthly a typical RCIS located Qianjiang City (Hubei Province) from July 2014 to June 2015, analyzed with principal component analysis (PCA) and compared between trenches rice areas during fallow period (Nov-May). The trench area comprehensive results showed that pH (7.48-8.68), NH4+-N (0.2-1.09 mg/L), NO2--N (<0.052 mg/L) conductivity (435-951...
Single-virus tracking provides a powerful tool for studying virus infection with high spatiotemporal resolution. Quantum dots (QDs) are used to label and track viral particles due their brightness photostability. However, labeling QDs is not easy. We developed new method by using the Strep-tag II/streptavidin system. In this method, were site-specifically ligated proteins in live cells then packaged into viral-like (VLPs) of tick-borne encephalitis (TBEV) Ebola during assembly. With TBEV...
Recent discovery on van der Waals (vdW) ferroelectrics has inspired extensive explorations of two-dimensional emerging heterostructures and devices with exotic functionalities. Their innate layer degree freedom allows the realization an interfacial antiferroelectric state, which is a challenge in bulk perovskite ferroelectrics. Here, we report observation gate-tunable interlayer antiferroelectricity 2H-stacked α-In2Se3 direct electric transport evidence consolidated by nonlinear optical...
Ebola virus (EBOV) causes severe hemorrhagic fever with high mortality rates. EBOV can infect many types of cells. During infection, polarized epithelial and endothelial cells are damaged, which promotes vascular instability dysregulation. However, the mechanism causing these symptoms is largely unknown. Here, we studied infection in Vero C1008 grown on semipermeable Transwell by using EGFP-labeled virus-like particles (VLPs). Our results showed that VLPs preferred to enter from apical cell...
Abstract Quarantine insects are economically important pests that frequently invade new habitats. A rapid and accurate monitoring method to trace the geographical sources of invaders is required for their prevention, detection, eradication. Current methods based on genetics typically time-consuming. Here, we developed a novel tracing insect gut microbiota. The source location microbiota can be used rapidly determine origin insect. We analyzed 179 samples from 591 individuals 22 quarantine...
In article number 1703207, Jianjun Chen, Zongqiang Cui, and co-workers develop an intranasal nanovaccine which provides protection against homo- heterosubtypic influenza. The 3M 2e-rHF is constructed by displaying three-sequential repeats of the influenza conserved antigen M2e on self-assembling recombinant human heavy chain ferritin (rHF) cage. Intranasal vaccination with 3M2e-rHF in absence adjuvants confers complete a lethal infection homosubtypic H1N1 H9N2 virus.
The global movement of people and goods has increased the risk biosecurity threats their potential to induce large economic, social, environmental harm. Integration biosafety monitoring networks become a top priority for addressing issues. In order resolve data standards integration problems in field China, Biosafety Surveillance Conceptual Data Model (BSCDM), which is an object-oriented, hierarchically designed, flexible scalable surveillance concept model, proposed this article. This model...