A5101524613- Viral Infections and Immunology Research
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- Microbial Natural Products and Biosynthesis
- Tendon Structure and Treatment
- Marine Biology and Environmental Chemistry
- Microplastics and Plastic Pollution
- Periodontal Regeneration and Treatments
- Nanoparticles: synthesis and applications
- Connexins and lens biology
- Wastewater Treatment and Nitrogen Removal
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- Plant biochemistry and biosynthesis
- Genetic diversity and population structure
- Gut microbiota and health
- Insect symbiosis and bacterial influences
- Inflammasome and immune disorders
- Chromosomal and Genetic Variations
- Wound Healing and Treatments
- Animal Virus Infections Studies
- Genetic and phenotypic traits in livestock
- Wildlife Ecology and Conservation
- Vasculitis and related conditions
- Berberine and alkaloids research
Chinese Academy of Agricultural Sciences
2023-2025
Agricultural Genomics Institute at Shenzhen
2024-2025
Innovation Team (China)
2025
China Agricultural University
2024-2025
Max Planck Institute for Biology
2024-2025
Harbin Veterinary Research Institute
2024-2025
Institute of Vegetables and Flowers
2024
Hunan Agricultural University
2024
Chinese Academy of Sciences
2018-2024
Beijing University of Technology
2023-2024
Aging impairs tendon stem/progenitor cell function and homeostasis, however, effective treatments for aging-induced diseases are lacking. Exosomes naturally derived nanoparticles that contain bioactive molecules, therefore, have attracted great interest in tissue engineering regenerative medicine. In this study, it is shown young exosomes secreted by stem cells from human exfoliated deciduous teeth (SHED-Exos) possess abundant anti-aging signals. These bio-nanoparticles can alleviate the...
Abstract Tendon injuries disrupt the balance between stability and mobility, causing compromised functions disabilities. The regeneration of mature, functional tendons remains a clinical challenge. Here, we perform transcriptional profiling tendon developmental processes to show that extracellular matrix-associated protein periostin (Postn) contributes maintenance stem/progenitor cell (TSPC) promotes regeneration. We recombinant (rPOSTN) proliferation stemness TSPCs, maintains tenogenic...
Mechanical force plays an important role in modulating stem cell fate and behaviours. However, how periodontal ligament cells (PDLSCs) perceive mechanical stimulus transfer it into biological signals, thereby promote alveolar bone remodelling, is unclear.An animal model of force-induced tooth movement a compressive vitro was used. After application, distance, mesenchymal osteoclast number, proinflammatory cytokine expression were detected tissues. Then, rat primary PDLSCs with or without...
Abstract Pyroptosis, an inflammatory caspase-dependent programmed cell death, plays a vital role in maintaining tissue homeostasis and activating responses. Orthodontic tooth movement (OTM) is aseptic force-induced bone remodeling process mediated by the activation of periodontal ligament (PDL) progenitor cells. However, whether how force induces PDL pyroptosis, thereby influencing OTM alveolar remains unknown. In this study, we found that mechanical induced expression pyroptosis-related...
Engineering a complete, physiologically functional, periodontal complex structure remains great clinical challenge due to the highly hierarchical architecture of periodontium and coordinated regulation multiple growth factors required induce stem cell multilineage differentiation. Using biomimetic self-assembly microstamping techniques, we construct bilayer consisting intrafibrillarly mineralized collagen resembling bone cementum, unmineralized parallel-aligned fibrils mimicking ligament....
Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a type III polyketide synthase (PKS) using one p-coumaroyl-CoA three malonyl-CoA molecules as substrates. Here, we report fungal non-ribosomal peptide synthetase -polyketide (NRPS-PKS) hybrid FnsA for formation. Feeding experiments with isotope-labelled precursors demonstrate that accepts not only p-coumaric acid (p-CA), but also p-hydroxybenzoic (p-HBA) starter units, or four elongation, respectively....
The ecological importance of the duplication and diversification gene clusters that synthesize secondary metabolites in fungi remains poorly understood. Here, we demonstrated subsequent a cluster produced two polyketide synthase cosmopolitan fungal genus Metarhizium. Diversification occurred promoter regions exon-intron structures Pks paralogs (Pks1 Pks2). These genes have distinct expression patterns, with Pks1 highly expressed during conidiation Pks2 infection. Different upstream signaling...
Autophagy, a lysosomal degradation pathway, serves as protective cellular mechanism in maintaining cell and tissue homeostasis under mechanical stimulation. As the mechanosensitive cells, periodontal ligament stem cells (PDLSCs) play an important role force-induced inflammatory bone remodeling tooth movement process. However, whether how autophagy PDLSCs influences process force stimuli is still unknown. In this study, we found that increased expression of protein LC3, number M1 macrophages...
Periodontal ligament (PDL), as a mechanical connection between the alveolar bone and tooth, plays pivotal role in force-induced orthodontic tooth movement (OTM). However, how force controls remodeling of PDL collagenous extracellular matrix (ECM) is largely unknown. Here, we aimed to evaluate stress distribution ECM fiber during process OTM. An experimental model was built by ligating coil spring left maxillary first molar central incisors. After activating for 7 days, distance 0.324 ± 0.021...
Maintaining the stemness of bone marrow mesenchymal stem cells (BMMSCs) is crucial for homeostasis and regeneration. However, in vitro expansion diseases impair BMMSC stemness, limiting its functionality tissue engineering. Using a deep learning-based efficacy prediction system sequencing, we identify natural small-molecule compound, dihydroartemisinin (DHA), that maintains enhances During long-term expansion, DHA preserves characteristics, including self-renewal ability unbiased...
Abstract Wild boars exhibit genetic and phenotypic diversity shaped by migrations local adaptations. Its expansion across Eurasia, especially in central Asia, remains underexplored. Here, we present newly sequenced whole-genome data of 47 wild from Eastern Central Europe, combined with 49 existing genomes, creating a comprehensive dataset 96 individuals. Our analyses show that Asian Southeast Suids split ∼3.6 Mya, Southern Chinese ancestors diverging ∼1.8 Mya. The between European-Near East...
With the increasing incidence of metabolic diseases (e.g. diabetes mellitus), exploring safe and effective blood glucose regulation strategies has become a hot research topic in field functional foods precision nutrition. This study focuses on multiple biological activities molecular mechanisms composite plant enzymes regulation, especially their efficacy regulation. By combining physicochemical characterisation enzyme kinetic studies, reveals mechanism action sugar metabolism. The showed...
As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, have been reported in many countries regions recent years. Moreover, porcine strains could cross interspecies barrier to infect human. To investigate epidemic trends of as well cross-immunoreactivity different isolates, epidemiological investigation about RVs (PoRVs) was performed during period 2020-2023 multiple provinces China. A total nine representative were identified. The phylogenetic...
Abstract Protein domains of transposable elements (TEs) and viruses increase the protein diversity host genomes by recombining with other domains. By screening 10 million eukaryotic proteins, we identified several that define multi-copy gene families frequently co-occur TE/viral Among these, a Tc1/Mariner transposase helix-turn-helix (HTH) domain was captured F-box genes in Caenorhabditis genus, creating new class genes. For specific members this class, like fbxa-215, found HTH is required...
Adult tendon stem/progenitor cells (TSPCs) are essential for maintenance, regeneration, and repair, yet they become susceptible to senescence with age, impairing the self-healing capacity of tendons. In this study, we employ a recently developed deep-learning-based efficacy prediction system screen potential stemness-promoting senescence-inhibiting drugs from natural products using transcriptional signatures stemness. The top-ranked candidate, prim-O-glucosylcimifugin (POG), saposhnikovia...
Abstract Shifts in gut microbial diversity and structure are one route by which vertebrate hosts adapt to local environmental conditions. However, recent studies have mostly been limited a single species, small sample sizes, or restricted geographic ranges. Therefore, drawing global picture of microbiome diversity, community structure, determinants for their adaptive shifts remains be elucidated. We here collected 6508 samples from 113 species covering diverse classes, feeding behaviors,...
To prevent COVID-19, the COVID-19 vaccine has been widely administered worldwide, but various complications accompany this vaccine. The aim of study was to investigate demographic patterns, clinical features, diagnostic findings, and treatment outcomes associated with shoulder injury related administration (SIRVA). This examined 22 patients SIRVA following vaccination from Web Science (WOS) PubMed databases. were categorized based on sex, age, type received, dose administered, latency...