A5113979538- Orthodontics and Dentofacial Orthopedics
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Temporomandibular Joint Disorders
- MicroRNA in disease regulation
- Dental Radiography and Imaging
- Neonatal Respiratory Health Research
- Periodontal Regeneration and Treatments
- Cardiovascular Function and Risk Factors
- Viral-associated cancers and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone Tissue Engineering Materials
- Plasma Applications and Diagnostics
- Cardiac Imaging and Diagnostics
- Pancreatitis Pathology and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound in Clinical Applications
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Thermal Regulation in Medicine
- Pancreatic and Hepatic Oncology Research
- Dental Implant Techniques and Outcomes
Collaborative Innovation Center of Advanced Microstructures
2025
Nanjing University
2025
Marquette University
2010-2025
University of Pennsylvania
2015-2024
Lianyungang Maternal and Children’s Hospital
2022-2024
Peking University
2009-2024
Guangdong Polytechnic Normal University
2024
King University
2024
National Clinical Research Center for Digestive Diseases
2020-2024
Southern Medical University
2023
Mesenchymal stem cell (MSC)–derived exosome plays a central role in the cell-free therapeutics involving MSCs and contents can be customized under disease-associated microenvironments. However, optimal MSC-preconditioning to enhance its therapeutic potential is largely unknown. Here, we show that preconditioning of gingival tissue-derived (GMSCs) with tumor necrosis factor-alpha (TNF-α) ideal for treatment periodontitis. TNF-α stimulation not only increased amount secreted from GMSCs, but...
Abstract Ten-eleven translocation (Tet) family-mediated DNA oxidation represents an epigenetic modification capable of converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which regulates various biological processes. However, it is unknown whether Tet family affects mesenchymal stem cells (MSCs) or the skeletal system. Here we show that depletion Tet1 and Tet2 results in impaired self-renewal differentiation bone marrow MSCs (BMMSCs) a significant osteopenia phenotype....
It is very important to assess the effectiveness of prone positioning (PP) in patients with severe acute respiratory distress syndrome (ARDS). However, it difficult identify who may benefit from PP. The purpose this study was investigate whether potential (PPP) can be predicted by lung ultrasound ARDS. In prospective study, 45 ARDS were included for assessment PPP. A PP examination (PLUE) protocol performed dorsal regions 16 areas at H0, H3, and H6 (0, 3, 6 h after PP). ultrasonography...
Over 300 billion of cells die every day in the human body, producing a large number endogenous apoptotic extracellular vesicles (apoEVs). Also, allogenic stem cell transplantation, commonly used therapeutic approach current clinical practice, generates exogenous apoEVs. It is well known that phagocytic engulf and digest apoEVs to maintain body's homeostasis. In this study, we show fraction metabolized integumentary skin hair follicles. Mechanistically, activate Wnt/β-catenin pathway...
A number of studies are now collecting diffusion tensor imaging (DTI) data across sites. While the reliability anatomical images has been established by a groups, DTI not studied as extensively. In this study, five healthy controls were recruited and imaged at eight centers. Repeated measures obtained two protocols allowing intra-subject inter-site variability to be assessed. Regional within white matter for standard rotationally invariant measures: fractional anisotropy, mean diffusivity,...
Engineering a complete, physiologically functional, periodontal complex structure remains great clinical challenge due to the highly hierarchical architecture of periodontium and coordinated regulation multiple growth factors required induce stem cell multilineage differentiation. Using biomimetic self-assembly microstamping techniques, we construct bilayer consisting intrafibrillarly mineralized collagen resembling bone cementum, unmineralized parallel-aligned fibrils mimicking ligament....
Abstract BACKGROUND: Positron emission tomography (PET) performed during cancer therapy (treatment monitoring) has shown promise for predicting treatment outcome. However, when used this purpose, PET generally is not considered standard care. Under the Medicare ‘coverage with evidence development’ policy, (and integrated PET/computed tomography) became a covered service monitoring if prospective registry data were collected. METHODS: The National Oncologic Registry collected questionnaire on...
Mesenchymal stem cells (MSCs) closely interact with the immune system, and they are known to secrete inflammatory cytokines in response stress stimuli. The biological function of MSC-derived remains elusive. Here, we reveal that even under physiological conditions, MSCs produce release a low level tumor necrosis factor alpha (TNFα), which is unexpectedly required for preserving self-renewal differentiation via autocrine/paracrine signaling. Furthermore, TNFα critically maintains MSC vivo...
Plasma-activated medium (PAM) has a broad prospect in the medical field. However, how to define plasma dose of PAM and what is dose–response relationship on cells are still open questions medicine. In this paper, based equivalent total oxidation potential (ETOP) introduced, S-logistic model used describe between corresponding lethal effects cells. Experiments A875/HaCaT cell viabilities indicate that ETOP as suitable for PAM. Evidence discrepancies 50% response intensity suggests can be...
Biomimetic intrafibrillarly-mineralized collagen (IMC) is a promising scaffold for bone regeneration because of its structural and functional similarity to natural bone. The objective this study was evaluate the potential IMC loaded with autologous periodontal ligament stem cells (PDLSCs) in large defects minipigs. A macroporous bone-like subfibrillar nanostructure fabricated using biomimetic bottom-up approach. Non-healing full thickness were established on cranial minipigs, hydroxyapatite...
Mesenchymal stem cells derived from gingiva (GMSCs) display profound immunomodulation properties in addition to self-renewal and multilineage differentiation capacities. Hydrogen sulfide (H2S) is not only an environmental pollutant, but also important biological gas transmitter health disease. We used in-vitro coculture system a mouse colitis model compare the immunomodulatory effects between control H2S-deficient GMSCs. The flow cytometry analysis was for T-cell apoptosis T-helper 17 (Th17)...
The introduction of oxygen vacancies into hexagonal In 2 O 3 nanorods via H treatment has significantly enhanced both the yield and selectivity C 5 OH in photothermal reduction CO .
Background The lowering of body temperature is a common, almost reflexive step in the daily care septic shock patient. However, effect different magnitudes fever control on outcome refractory patients with very poor controversial and has yet to be explored. Methods This prospective trial examined sixty-five core higher than 38.5°C. Patients were randomly assigned group achieving “low temperature” range (LT group: 36.0-37.5 °C) or “high (HT 37.5-38.3 by physical methods including water-flow...
Diabetes is a major public health issue because of its widely epidemic nature and lack cure. Here, we show that pancreas-derived mesenchymal stem cells (PMSCs) are capable regenerating exocrine pancreas when implanted into the kidney capsule mice with streptozotocin (STZ)–induced diabetes. Mechanistically, found regenerated elevated interleukin-6 (IL-6) in PMSC implants, which transiently activated tumor necrosis factor–α (TNF-α) interferon-γ (IFN-γ) to inhibit IL-17, thereby rescuing...