A5101968261- Retinal Development and Disorders
- Kruppel-like factors research
- Cancer-related gene regulation
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Traumatic Ocular and Foreign Body Injuries
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Glaucoma and retinal disorders
- Epigenetics and DNA Methylation
- Facial Trauma and Fracture Management
- Antimicrobial Resistance in Staphylococcus
- Retinal Imaging and Analysis
- RNA Interference and Gene Delivery
- Photoreceptor and optogenetics research
- Retinopathy of Prematurity Studies
- Mitochondrial Function and Pathology
- Antimicrobial Peptides and Activities
- Congenital Heart Disease Studies
- bioluminescence and chemiluminescence research
- Physical Activity and Health
- Ophthalmology and Eye Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Supramolecular Self-Assembly in Materials
- Plant Toxicity and Pharmacological Properties
- Ubiquitin and proteasome pathways
Henan Provincial Eye Hospital
2021-2024
Zhengzhou University
2021-2024
Henan Provincial People's Hospital
2021-2024
New York Institute of Technology
2023
Affiliated Eye Hospital of Wenzhou Medical College
2023
Wenzhou Medical University
2023
Soochow University
2022
Southeast University
2022
Dali University
2019-2021
Guangdong Medical College
2018
Abstract Ewing’s sarcoma (ES) is a rare and highly aggressive malignant tumor arising from bone soft tissue. Suffering intractable or recurrent diseases, the patients’ therapy options are very limited. It extremely urgent to identify novel potential therapeutic targets for ES put them into use in clinical settings. In present study, high-throughput screening of small molecular pharmacy library was performed. The killing effect Aurora kinase A (AURKA) inhibitor TCS7010 cells identified, AURKA...
microRNAs are regulatory molecules regarded as important in the pathogenesis of different types tumors. microRNA-216a (miR-216a-5p) has been identified a tumor suppressor multiple malignancies. However, role miR-216a-5p small cell lung cancer (SCLC) remains obscure. The objective this study was to investigate miR-216a-5p/Bcl-2 axis SCLC pathogenesis.All experimental methods used were follows: microarray analysis, culture, transient, and stable gene transfection; real-time fluorescence PCR;...
Abstract Background Open-globe injuries (OGIs) remain the important cause of visual impairment and loss in all ages. Computed Tomography (CT) is a useful common tool evaluation eyeball. Prognostic value CT scan OGIs has been evaluated many studies. However, there no published consistent systematic scoring method for OGIs. The purpose this study was to evaluate characteristics build according scans which may aid clinicians management Methods Retrospective chart review inpatients with clinical...
Abstract To endow non‐antibacterial molecules with highly efficient bactericide activity is an important but challenging issue. Herein, a kind of cell‐penetrating peptide octa‐arginine (R8) found to be effective in activating antibacterial ability when assembling anionic surfactant sodium dodecyl sulfate (SDS), while individual R8 or SDS shows poor no ability. By combined electrostatic, hydrogen bond, and hydrophobic interactions, associate into wormlike micelle lamellar structure by forming...
The two-component system VraSR responds to the cell wall-active antibiotic stress in Staphylococcus epidermidis. To study its regulatory function biofilm formation, a vraSR deletion mutant (ΔvraSR) was constructed using S. epidermidis strain 1457 (SE1457) as parent strain. Compared SE1457, ΔvraSR showed impaired formation both vitro and vivo with higher ratio of dead cells within biofilm. Consistently, produced much less polysaccharide intercellular adhesin (PIA). also increased...
Purpose To describe the characteristics, managements, and outcomes of pediatric open globe injury (OGI) in central China. Methods Retrospective chart review diagnosis patients with OGI between 2017 2020 at Henan Eye Hospital. Four hundred one eyes younger than 17 years were included this study. Open was classified according to Birmingham Trauma Terminology system (BETT). Age, sex, history, cause, month trauma, treatment received, recorded. Visual acuity documented standard visual (decimals)....
Lacrimal canalicular laceration can be caused by trauma on the ocular adnexa, such as penetrating or blunt injuries, accounting for approximately 16% of eyelid lacerations and 20% eye traumas. Historically, anastomosis combined with bi-canalicular mono-canalicular stent intubation has been used repair. In this study, we analyzed epidemiological characteristics lacrimal evaluate clinical outcomes repair using in central China. It aims to provide a reference work.This is review 338 patients...
Purpose: To describe the characteristics, management, and outcomes of adult severe open-globe injured (OGI) eyes. Methods: Retrospective chart review inpatients with initial visual acuity (VA) light perception (LP) or no (NLP) associated OGI between 2017 2020 at Department Ophthalmology, Henan Eye Institute, Hospital, provincial People's Hospital. Results: Six hundred twenty-five eyes 622 patients VA LP NLP injuries (OGIs) were included. The mean age was 47.8 ± 14.1 years range from 18 to 91...
To investigate and compare the latency amplitude of electroretinogram (ERG) photopic negative response (PhNR) between young old Lewis rats.Thirteen rats were divided into two groups according to ages, group (3-month n=5) (24 month n=8). The ERGs left eyes measured a-wave, b-wave PhNRs recorded compared ages. mean values statistically analysed by t-test.The evidently prolonged in showed significant difference (P<0.05). There was no regarding latency, noted PhNRs.The PhNR aged possibly...
Purpose To clarify the effects of acute hyperglycemia on responses choroidal structural components and vascularity index during light modulation in healthy participants using techniques including image binarization artificial intelligence (AI) segmentation based swept-source optical coherence tomography (SS-OCT). Methods Twenty-four eyes 24 were imaged at different stages after ambient light, 40 min dark adaptation, 5 adaptation two imaging sessions: control receiving 75 g oral glucose...
To study the characteristics of photopic flash electroretinogram (ERG) in normal adult SD rats.Sixty rats aged 9 to 12 weeks were enrolled this study. Photopic ERG recorded from these 60 rats. The results statistically analyzed with SPSS software.Stable a, b and PhNR wave could be each rat. Implicit time a wave, implicit amplitude fit distribution. was (124.6±8.5) ms smallest coefficient variation 0.07. (11.3±4.2) μV 0.37. There no difference between female male rats.Photopic is an objective...
To summarize the therapeutic effects of modified double root translocation (MDRT) in management congenital heart disease-transposition great arteries (TGA) with ventricular septum defect (VSD) and left outflow tract obstruction (LVOTO). From May 2013 to March 2015, we treated 6 patients (4 males, 2 females, aged from 1 year 8 months old 5 years old) complete transposition obstruction, SaO2 54 ± 7.3%; velocity or pulmonary valve measured by Doppler was 4.46 0.15 m/s, Nakata index 217 32...
<p>Supplementary Figure S8 shows photos and histological sections of xenografts livers.</p>