A5014450004- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Sinusitis and nasal conditions
- Herbal Medicine Research Studies
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Contact Dermatitis and Allergies
- Obstructive Sleep Apnea Research
- Fungal Biology and Applications
- Mycobacterium research and diagnosis
- Respiratory and Cough-Related Research
- Pharmacological Effects of Natural Compounds
- Immunodeficiency and Autoimmune Disorders
- Neuroscience of respiration and sleep
- Oral Health Pathology and Treatment
- Poisoning and overdose treatments
- IL-33, ST2, and ILC Pathways
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- Mechanical Circulatory Support Devices
Johns Hopkins University
2016-2025
Johns Hopkins Medicine
2014-2025
Nationwide Children's Hospital
2023
Johns Hopkins Bayview Medical Center
2013
Icahn School of Medicine at Mount Sinai
2009-2013
The University of Sydney
2000
Westmead Hospital
2000
The Alfred Hospital
1992
Critical examination of the quality and validity available allergic rhinitis (AR) literature is necessary to improve understanding appropriately translate this knowledge clinical care AR patient. To evaluate existing literature, international multidisciplinary experts with an interest in have produced International Consensus statement on Allergy Rhinology: Allergic Rhinitis (ICAR:AR).Using previously described methodology, specific topics were developed relating AR. Each topic was assigned a...
Chronic rhinosinusitis with nasal polyps (CRSwNP) can be a severe and debilitating disease associated significant morbidity, loss of smell, sinus pressure asthma exacerbations. Eosinophils play role in the majority (85%) patients. Benralizumab, an afucosylated monoclonal antibody directed against IL-5 receptor, has powerful apoptotic effects on eosinophils.We sought to investigate therapeutic benefit inhibiting receptor using benralizumab treat polyps.Patients NP (defined by endoscopic grade...
Summary Background High‐affinity IgE receptor (FcɛRI) expression on blood dendritic cells reportedly correlates with serum levels. Our studies demonstrate that plasmacytoid (pDCs) secrete pro‐inflammatory cytokines (IL‐6, TNF‐α) following FcɛRI stimulation – a mode of activation simultaneously reduces Toll‐like 9 (TLR9). Whether or not TLR9 and/or levels and their function relate to allergic status is unknown. Objective The aim this study compare the innate (TLR9‐mediated) immune response...
ICAR: Allergic Rhinitis Author Disclosure of Conflict Interest Conflicts Form for Authors International Forum Allergy & Rhinology-International Consensus Statement on and Rhinology: supplement Please note: The publisher is not responsible the content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
Summary Background We recently reported that human blood dendritic cells from allergic subjects have impaired IFN‐α production following toll‐like receptor 9 (TLR9)‐dependent innate immune stimulation. It is not known how subcutaneous allergen immunotherapy (SCIT) affects cell responses. Objective The aim of this study to determine SCIT function. Methods Peripheral mononuclear (PBMC) and plasmacytoid (pDCs) were isolated the seven dust mite at baseline upon reaching a standard maintenance...
Introduction: Plasmacytoid dendritic cells (pDC) are unique antigen-presenting that may be implicated in allergic disease because they bind IgE on their surface and modulate important Th1/Th2 cytokine responses. The authors previously discovered is not readily removed from pDCs using omalizumab to the same extent observed for basophils, suggesting a portion of membrane bound. Methods: A cross-sectional study was performed recruited adult volunteers Johns Hopkins Asthma & Allergy Clinic,...
Worldwide, cat allergies affect 15% of the population. Cat allergens are ubiquitous and challenging to eliminate from homes, making it difficult implement effective allergen reduction strategies. Developing strategies reduce in homes could alleviate burden allergic diseases, enhance symptom management, lower healthcare expenses, improve patients’ quality life. Studies have produced varied results concerning effectiveness specific environmental control measures lowering levels improving...
Obstructive sleep apnea is highly prevalent in children with asthma, particularly obese children. The sleep-related breathing disorder screening questionnaire has low accuracy for obstructive asthma. Our goal was to identify the questions on survey associated asthma.Participants completed survey, underwent polysomnography and their body mass index z-score measured. Participants scores above 0.33 were considered high risk those an apnea-hypopnea ≥ 2 events/h classified as having apnea....
Eotaxin/CCL-11 is a major chemoattractant that contributes to eosinophilic inflammation in asthma. Glucocorticoids inhibit inflammation, but long-time exposure may cause paradoxical adverse effects by augmenting eotaxin/CCL-11production. The aim of this study was determine if 7,4′-dihydroxyflavone (7,4′-DHF), the eotaxin/CCL11 inhibitor isolated from Glycyrrhiza uralensis, reduces vitro eotaxin production induced dexamethasone (Dex) exposure, and so, elucidate mechanisms inhibition. Human...
Th2 cytokines play a dominant role in the pathogenesis of allergic asthma. Interferon gamma (IFN-γ), Th1 cytokine, links to therapeutic mechanisms Interleukin (IL)-10, regulatory is involved induction immune tolerance. We previously demonstrated that Anti-Asthma Simplified Herbal Medicine Intervention (ASHMI) suppressed and increased IFN-γ patients with asthma animal models, but its bioactive compound unknown. Ganoderic acid beta (GAB) was isolated from Ganoderma lucidum (one herb ASHMI)....
It is well established that Th2 dominant responses play a central role in the pathogenesis of allergic diseases. In contract, Th1 and T regulatory immunity inhibit response induces immune tolerance to harmless environmental antigens. Ganoderic acid β (GAβ) was isolated from Ganoderma lucidum, widely used medicinal mushroom with immunomodulatory activity. Modulatory effect GAβ determined compared dexamethasone (Dex). by liquid-liquid extraction, silica gel column chromatography, preparative...
Allergy skin test reliability depends on the reagents and controls selected. Histamine is used at 1 mg/ml 6 concentration but few studies address rationale for selecting one versus other how this may impact diagnostic accuracy.To determine rate of false negative allergen tests responses between UniTest PC (using mg/mL histamine) Quintip devices mg/mL) 4 common aeroallergens.Subjects aged 18-65 with symptoms allergy to cat and/or ragweed received testing aeroallergens (dust mite mix, timothy...