A5070551509- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Urologic and reproductive health conditions
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Regional Development and Environment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Soft tissue tumor case studies
- Big Data Technologies and Applications
- Breast Cancer Treatment Studies
- Synthesis and biological activity
- Esophageal Cancer Research and Treatment
- E-commerce and Technology Innovations
- Effects of Radiation Exposure
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Metal-Catalyzed Oxygenation Mechanisms
- Quinazolinone synthesis and applications
- Pancreatic and Hepatic Oncology Research
- Cancer therapeutics and mechanisms
- Advanced Radiotherapy Techniques
- Epigenetics and DNA Methylation
Peking University
2022-2023
Peking University Cancer Hospital
2022-2023
First Affiliated Hospital Zhejiang University
2021-2023
Second Military Medical University
2023
Zhejiang University
2020-2021
Everbright International (China)
2021
Introduction Cholangiocarcinoma (CCA) is a malignant tumor of the biliary epithelium with poor prognosis. The lack biomarkers to predict therapeutic response and prognosis one major challenges for CCA treatment. Tertiary lymphoid structures (TLS) provide local pivotal microenvironment immune responses. prognostic value clinical relevance TLS in remain unclear. We aimed explore characteristics significance CCA. Methods investigated using surgery cohort containing 471 patients (cohort 1) an...
Radioresistance is the major reason for failure of radiotherapy in esophageal squamous cell carcinoma (ESCC). Previous evidence indicated that stanniocalcin 2 (STC2) participates various biological processes malignant tumors. However, researches on its effect radioresistance cancers are limited. In this study, STC2 was screened out by RNA-sequencing and bioinformatics analyses as a potential prognosis predictor ESCC radiosensitivity then determined to facilitate radioresistance. We found...
BACKGROUND: Mucinous prostate cancer (PCa) is an extremely rare form of malignancy. To date, the limited knowledge its biology and outcomes stems from mostly small, single institution experiences. We analyzed Surveillance, Epidemiology, End Results (SEER) database to explore incidence treatment mucinous PCa together with prognostic factors gain relatively large consolidated insights. METHODS: Age-adjusted (AAI) rates were evaluated over time. Propensity score matching (PSM) Kaplan-Meier...
Globally, lung cancer is one of the most malignant tumors, which adenocarcinoma (LUAD) common subtype, with a particularly poor prognosis. Ciclopirox olamine (CPX) an antifungal drug and was recently identified as potential antitumor agent. However, how CPX its mechanism action function during LUAD remain unclear.The effects on cell proliferation, cycle, reactive oxygen species (ROS) levels, apoptosis were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT)...
Radiation-induced heart injury (RIHI) limits the dose delivery of radiotherapy for thoracic cancer. Shenmai injection (SMI) is reported to have potential cytoprotective properties and commonly used in cardiovascular diseases. So, we aimed investigate protective effects SMI treatment on RIHI. In this study, established RIHI model using Sprague-Dawley rats H9c2 cell line. vivo, biochemical assay was measure serum cardiac injury-related biomarkers echocardiography evaluate function. The...
Whether to prophylactically irradiate the ipsilateral internal mammary chain (IMC) in post-mastectomy radiotherapy (PMRT) remains controversial because of equivocal clinical benefits against added toxicities. Our previous study revealed that cardiac dose was decreased during left-sided breast with abdominal deep inspiration breath-hold (aDIBH) as compared free-breathing (FB) and thoracic (tDIBH). Here we present dosimetric advantage aDIBH for patients undergoing PMRT IMC coverage.We...
Abstract Tyrosine kinase inhibitors (TKIs)-based systemic therapy for advanced hepatocellular carcinoma (HCC) has only limited clinical benefit and reaches a bottleneck due to its drug resistance. Here, through whole transcriptome sequencing (RNA-Seq) lipidomic analysis, we uncover that lipid metabolism reprogramming mediated by unconventional prefoldin RPB5 interactor (URI) endows HCC with resistance TKIs-induced ferroptosis. Mechanistically, URI directly interacts TRIM28 promotes p53...
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is extremely rare, and most of them are immediately treated for radical resection. However, the information concerning its natural history remains unclear. In this report, we presented a patient with parapharyngeal SFT/HPC, who was not surgical resection at first diagnosis. After approximately 3 years, tumor volume doubling time (TVDT) specific growth rate (SGR) could be measured through serial magnetic resonance imagings. The TVDTs in...
Combined with the analysis of current management status production technology transformation and overhaul project in power grid enterprises, a lean strategy projects based on fusion data multiple platforms big is proposed. In order to achieve accurate control process such as transformation, special cost items, include 1) analyzing deviation image progress, actual filing progress procedure electronic documents, budget implementation schedule respectively PMS, ERP Economic&Legal system; 2)...