A5050779617- Zebrafish Biomedical Research Applications
- Physiological and biochemical adaptations
- MicroRNA in disease regulation
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Aquaculture disease management and microbiota
- Axon Guidance and Neuronal Signaling
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Cancer Research and Treatments
- Laser Applications in Dentistry and Medicine
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Infrared Thermography in Medicine
- Bone fractures and treatments
- Neonatal Respiratory Health Research
Technische Universität Dresden
2014-2023
KU Leuven
2022-2023
University Hospital Carl Gustav Carus
2022
Zebrafish have an unlimited capacity to regenerate bone after fin amputation. In this process, mature osteoblasts dedifferentiate osteogenic precursor cells and thus represent important source of newly forming bone. By contrast, differentiated do not appear contribute repair injuries in mammals; rather, form anew from mesenchymal stem cells. This raises the question whether osteoblast dedifferentiation is specific appendage regeneration, a special feature lepidotrichia fish fin, or process...
Glucocorticoids are widely used as therapeutic agents to treat immune-mediated diseases in humans because of their anti-inflammatory and immunosuppressive effects. However, glucocorticoids have various adverse effects, particular rapid pronounced bone loss associated with fractures glucocorticoid-induced osteoporosis, a common form secondary osteoporosis. In zebrafish, which increasingly study processes regeneration disease, show detrimental effects on tissue; however, the underlying...
Long-term glucocorticoid administration in patients undergoing immunosuppressive and anti-inflammatory treatment is accompanied by impaired bone formation increased fracture risk. Furthermore, can lead to wound healing altered cell metabolism. Recently, we showed that exposure of zebrafish the prednisolone during fin regeneration impacts negatively on length, formation, osteoblast function regenerate. The underlying cellular molecular mechanisms impairment, however, remain incompletely...
Zebrafish are able to regenerate various organs, including appendages (fins) after amputation. This involves the regeneration of bone, which regrows within roughly two weeks injury. Furthermore, zebrafish heal bone rapidly trepanation skull, and repair fractures that can be easily introduced into bony fin rays. These injury assays represent feasible experimental paradigms test effect administered drugs on forming bone. Here, we describe use these 3 models their combined with systemic...
ABSTRACT In zebrafish, transgenic labeling approaches, robust regenerative responses and excellent in vivo imaging conditions enable precise characterization of immune cell behavior response to injury. Here, we monitored osteoblast-immune interactions bone, a tissue which is particularly difficult image tetrapod species. Ablation individual osteoblasts leads recruitment neutrophils macrophages varying numbers, depending on the extent initial insult, initiates generation cathepsin K+...
As a treatment for various immune-mediated diseases, the use of glucocorticoids as anti-inflammatory and immunosuppressive agents is common practice. However, their severely hampered by risk development adverse effects such secondary osteoporosis, skin atrophy, peptic ulcer formation. The exact molecular cellular mechanisms underlying those effects, which involve most major organ systems, are not yet fully understood. Therefore, investigation great importance to improve regimens patients....
Abstract In zebrafish, transgenic labeling approaches, robust regenerative responses and excellent in vivo imaging conditions enable precise characterization of immune cell behavior response to injury. Here, we monitored osteoblast-immune interactions bone, a tissue which is particularly difficult image tetrapod species. Ablation individual osteoblasts leads recruitment neutrophils macrophages varying numbers, depending on the extent initial insult, initiates generation cathepsinK +...