A5100604443- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Heavy Metal Exposure and Toxicity
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Gut microbiota and health
- Escherichia coli research studies
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Peptidase Inhibition and Analysis
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Inhalation and Respiratory Drug Delivery
- Silk-based biomaterials and applications
- Advancements in Transdermal Drug Delivery
Pusan National University
2023-2025
The Ohio State University
2014-2024
Konkuk University
2017
Ohio University
2015-2016
Kwangwoon University
2013
Keimyung University
2012
Catholic Kwandong University
2006
Kyoto University
1996-2001
Significance We report the discovery of fundamental roles for noncanonical inflammasome molecule Caspase-4/11 in promoting pathological inflammatory and prothrombotic pathways severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) infections. Our work demonstrates that Caspase-11 has a broader role immune responses beyond its previously appreciated effects bacterial Further, we show Caspase-11–deficient mice infected with SARS–CoV-2 fare significantly better terms overall illness, lung...
With the rapid increase in SARS-CoV-2 cases children, a safe and effective vaccine for this population is urgently needed. The MMR (measles/mumps/rubella) has been one of safest most human vaccines used infants children since 1960s. Here, we developed live attenuated recombinant mumps virus (rMuV)–based candidates using MuV Jeryl Lynn (JL2) strain backbone. soluble prefusion spike protein (preS) gene, stablized by two prolines (preS-2P) or six (preS-6P), was inserted into genome at P–M F–SH...
Myostatin (MSTN) is a key negative regulator of muscle growth and development, an increase mass achieved by inhibiting MSTN signaling. In the current study, five alternative splicing isoforms mRNAs in avian species were identified various tissues. Among these five, three truncated forms myostatin, MSTN-B, -C, -E created premature stop codons produced partial prodomains encoded from exon 1. MSTN-B second dominant isoform following full-length MSTN-A, their expression was dynamically regulated...
Significance We report that suppression of the serine protease elastase reshapes innate responses induced by injected vaccines containing alum adjuvant. This reprogramming improves induction protective antibodies in bloodstream and stimulates signals, which support development antibody mucosal tissues. Our findings identify as regulator blunts adjuvant activity alum. They also demonstrate vaccination via routes is not an absolute requirement for tissues secretions. Supplementation alum-based...
Background: Particulate matter (PM) is a major environmental pollutant that induces oxidative stress, inflammation, and extracellular matrix (ECM) degradation, leading to skin damage accelerated aging. Xanthorrhizol (XAN), bioactive compound derived from Curcuma xanthorrhiza Roxb., exhibits anti-inflammatory antioxidative properties, making it promising candidate for protecting against PM-induced damage. This study investigated the protective effects of XAN C. supercritical extract (CXSE) on...
ABSTRACT Aminopeptidases A, B, and N dipeptidase D, with broad substrate specificity, are the four cysteinylglycinases of Escherichia coli K-12, there is no peptidase specific for cleavage cysteinylglycine.
Intestinal epithelial cells (IECs) are known to regulate allergic sensitization. We addressed the role of intrinsic IKKβ signaling in IECs effector phase allergy following oral allergen challenge and its impact on severity symptoms is poorly. Upon orally sensitization by co-administration ovalbumin with cholera toxin as adjuvant, wild-type mice lacking (IKKβΔIEC mice) developed similar levels serum IgE allergen-specific secretory IgA. However, subsequent challenges gut promoted reduced...
Abstract Cadmium is a toxic heavy metal that can be ingested due to its presence in contaminated water and accumulation leafy vegetables, fish grains. Since cadmium compete with iron for intestinal absorption, long-term ingestion of change composition gut-commensal bacteria by inhibiting the growth selected bacteria. Gut-commensal are critical maintain homeostasis since they limit attachment infectious agents, regulate pro-and anti-inflammatory milieu secretory IgA levels. However,...
The process of lipolysis is essential for regulating the catabolism cellular fat stores. Therefore, knowledge contributes to improving porcine production, such as reducing back fat, enhancing lean meat, and controlling marbling. Comparative gene identification-58 (CGI-58) plays an important role in multi-enzyme-mediated lipolysis. It was identified co-activator adipose triglyceride lipase (ATGL), which performs first step breaking down triacylglycerol generating diacylglycerol NEFA. We...
Abstract Low doses of cadmium can be ingested due to its presence in contaminated water and accumulation leafy vegetables, fish grains. Pollutants are believe contribute the increased incidence allergy diseases. We addressed whether chronic ingestion low could impact allergic sensitization thus, favor development Conventional C57BL/6 mice given drinking for 28 days exhibited a significant reduction bacterial diversity, an alteration Firmicutes Bacteriodetes ratio. This treatment also...
Abstract Obesity has been associated with dysbiosis, but innate mechanisms linking intestinal epithelial cell subsets and obesity remain poorly understood. Using mice lacking Paneth cells (Sox9 ΔIEC mice), small specialized in the production of antimicrobial products cytokines, we show that dysbiosis alone does not induce or metabolic disorders. Loss reduced ILC3 increased ILC2 numbers lamina propria. High-fat diet (HFD) induced higher weight gain more severe disorders Sox9 mice. Further,...
It is well established that dendritic cells and macrophages play a role in antigen presentation to B T shaping cell responses via cytokines they produce. We have previously reported depletion of neutrophils improves the production mucosal IgA after sublingual immunization with Bacillus anthracis edema toxin as adjuvant. These past studies also demonstrated an inverse correlation exists between number by cells. Using specific inhibitors elastase, we addressed whether elastase activity...
The colonic microenvironment, stemming from microbial, immunologic, stromal, and epithelial factors, serves as an important determinant of the host response to enteric pathogenic colonization. Infection with bacterial pathogen Citrobacter rodentium elicits a strong mucosal Th1-mediated colitis monocyte-driven inflammation activated via classical NF-κB pathway. Research has focused on leukocyte-mediated signaling main driver for C. rodentium-induced colitis, however we hypothesize that cell...
Abstract Sublingual immunization is emerging as an alternative to nasal and induction of mucosal IgA responses. Using Bacillus anthracis edema toxin (EdTx) adjuvant, we previously showed that innate responses triggered after sublingual could limit generation We tested whether co-administration a neutrophil elastase inhibitor (NEI) rescue the ability EdTx induce broad antibody responses, including IgA. NEI supplementation vaccines containing promoted antigen-specific serum but also enhanced...
Abstract SARS-CoV-2 is a worldwide health concern, and new treatment strategies are needed 1 . Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4), its mouse homologue, caspase-11 (CASP11), upregulated in infections, CASP4 expression correlates with severity of infection humans. SARS-CoV-2-infected Casp11 -/- mice were protected from severe weight loss lung pathology, including...
Anti-CD3-epsilon (CD3e) monoclonal antibodies (mAbs) and CD3e immunotoxins (ITs) are promising targeted therapy options for various T-cell disorders. Despite significant advances in mAb IT engineering, vascular leakage syndrome (VLS) remains a major dose-limiting toxicity ITs has been poorly characterized recent “engineered” mAbs. This study undertakes direct comparison of non-mitogenic CD3e-mAb (145-2C11 with Fc-silentTM murine IgG1: S-CD3e-mAb) new murine-version CD3e-IT...