A5064168964- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Epilepsy research and treatment
- MicroRNA in disease regulation
- Vitamin C and Antioxidants Research
- Aldose Reductase and Taurine
- IL-33, ST2, and ILC Pathways
- Vitamin K Research Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Obesity and Health Practices
- Circular RNAs in diseases
- Inflammatory Bowel Disease
- Trauma and Emergency Care Studies
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Adenosine and Purinergic Signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Promotion and Cardiovascular Prevention
- Congenital gastrointestinal and neural anomalies
- Cardiac Health and Mental Health
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Alcoholism and Thiamine Deficiency
Temple University Hospital
2021-2022
University of Pennsylvania
2009-2014
Children's Hospital of Philadelphia
2011-2014
Center for Digestive and Liver Diseases
2011
American Academy of Neurology
2009
University of Birmingham
1989-1994
University of London
1994
University of Southampton
1994
London School of Hygiene & Tropical Medicine
1994
Selly Oak Hospital
1988-1991
<h3>Abstract</h3> <b>Objective</b> : To measure the change in cardiovascular risk factors achievable families over one year by a screening and lifestyle intervention general practice. <b>Design</b> Randomised controlled trial 26 practices 13 towns Britain. <b>Subjects</b> 12472 men aged 40-59 their partners (7460 5012 women) identified household. <b>Intervention</b> Nurse led programme using family centred approach with follow up according to degree of risk. <b>Main outcome measures</b>...
ABSTRACT Biliary atresia (BA) is a pediatric liver disease of unknown underlying etiology, in which fibroinflammatory destruction the extrahepatic biliary system leads to obstructive cholestasis. MicroRNAs are class short (18–23 nucleotide), noncoding RNA molecules, act as negative regulators target mRNA stability and translation. The importance these molecules normal diseased has been demonstrated, but their potential role pathogenesis BA not addressed. We have profiled changes microRNA...
Journal Article Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon Get access Adam M. Zahm, Zahm The Children's Hospital Philadelphia Research Institute, Philadelphia, PA 19104, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nicholas J. Hand, Hand Daphne Tsoucas, Tsoucas Claire L. Le Guen, Guen Robert N. Baldassano, Baldassano Joshua R. Friedman *Corresponding at: 3615 Civic Center Blvd., Abramson Suite 902G, United States...
A 2‐year randomized placebo‐controlled double‐blind trial of 250 mg day −1 the aldose reductase inhibitor Sorbinil in severe symptomatic chronic peripheral neuropathy was performed 21 diabetic patients. Due to adverse reactions 8 patients completed on and 6 placebo. Despite differences baseline neurophysiological parameters, duration diabetes, presence retinopathy between placebo treatment groups, there were no initial vitro platelet aggregation, albumin excretion rate (AER) or muscle...
The incidence of eosinophilic esophagitis (EoE) has increased in the past several years, yet our understanding its pathogenesis remains limited. To test hypothesis that microRNAs (miRNAs) are altered children with EoE, miRNAs were profiled esophageal mucosa biopsies obtained from patients active disease ( n = 5) and healthy control subjects 6). Fourteen significantly between groups; four these decreased EoE patients. A panel five (miR-203, miR-375, miR-21, miR-223, miR-142-3p) selected for...
BackgroundCoronavirus disease 2019 (COVID-19) is a viral pulmonary infection that can progress to cytokine storm syndrome because of widespread dysregulated inflammatory response. Many patients at risk for severe COVID-19 manifestation have been identified as those with preexisting conditions origin, well impair appropriate immune response, such obesity.ObjectivesThe aim this study describe the manifestation, clinical course, and biomarker milieu in obesity.SettingUniversity Hospital...
MicroRNAs have been found to play a profound role in embryonic and post-natal development through their regulation of processes such as cell proliferation, differentiation, morphogenesis. The microRNA-30 (miR-30) family is necessary for vertebrate hepatobiliary development; however, the mechanism which miR-30 regulates these not fully understood. Here, we identify genes directly regulated by that characterized key developmental factors. targets were confirmed via luciferase reporter assay,...
Smoking history is a known risk factor for significant chronic diseases as well pulmonary infections; however, the impact of smoking status on coronavirus disease 2019 (COVID-19) outcomes has not been conclusively characterized. This study aims to evaluate association COVID-19 outcomes, and explore mechanism by which smoking-related comorbidities relate outcomes.Patients admitted with SARS-CoV-2 infection from November 2020 through January 2021 were included in this study. Causal mediation...
Journal Article Abnormalities of Ascorbic Acid (Vitamin C) Metabolism in Elderly Patients with Diabetes Mellitus Get access A.J. Sinclair, Sinclair Department Geriatric Medicine and Medicine, University Birningham Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Le Guen, Guen L. Gray, Gray J. Lunec, Lunec B. Isaacs, Isaacs A. H. Barnett Age Ageing, Volume 19, Issue suppl_2, 1990, Pages P10-d–P11, https://doi.org/10.1093/ageing/19.suppl_2.P10-d Published: 01...
Conference Abstract| January 01 1988 Ferroxidase Activity and the Fructosamine Assay in Diabetic Pregnancy C.M. Florkowski; Florkowski *Department of Medicine, East Birmingham Hospital University Search for other works by this author on: This Site PubMed Google Scholar C. Le Guen; Guen 1Department Clinical Chemistry, Selly Oak B. Rowe; Rowe A.H. Barnett; Barnett A.F. Jones; Jones J. Winkles; Winkles Lunec Clin Sci (Lond) (1988) 74 (s18): 73P. https://doi.org/10.1042/cs074073Pb Views Icon...