A5024729327- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Physical Activity and Health
- Genetic Associations and Epidemiology
- Fatty Acid Research and Health
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Hormonal and reproductive studies
- Health Systems, Economic Evaluations, Quality of Life
- Urban Transport and Accessibility
- Nutrition and Health in Aging
- Digestive system and related health
- Atrial Fibrillation Management and Outcomes
- Retinoids in leukemia and cellular processes
- Alcohol Consumption and Health Effects
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Blood properties and coagulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
Leiden University Medical Center
2017-2025
Abstract Aims/hypothesis We hypothesised that the insulin-sensitising effect of physical activity depends on timing activity. Here, we examined cross-sectional associations breaks in sedentary time and with liver fat content insulin resistance a Dutch cohort. Methods In 775 participants Netherlands Epidemiology Obesity (NEO) study, assessed time, different intensities using sensors, by magnetic resonance spectroscopy ( n =256). Participants were categorised as being most active morning...
Current evidence on the associations between food environment and type 2 diabetes (T2D) is inconsistent did not investigate behavioral mediating pathway. To whether accessibility of retailers in residential neighborhood associated with T2D incidence four Dutch prospective cohorts, this mediated by diet quality. In multi-cohort study we included cohort studies (ntotal=10,249). Nearest distances from all participants' home to supermarkets, fast-food outlets green grocers were calculated at...
The aim of this study was to investigate the associations among sex hormone-binding globulin (SHBG), visceral adipose tissue (VAT), liver fat content, and risk type 2 diabetes (T2D). In Netherlands Epidemiology Obesity study, 5,690 women (53%) men (47%) without preexisting were included followed for incident T2D. SHBG concentrations measured in all participants, VAT using MRI, content proton magnetic resonance spectroscopy a random subset 1,822 participants. We examined between linear...
It remains unclear to what extent habitual physical activity and sedentary time (ST) are associated with visceral fat liver fat. We studied the substitution of ST spent physically active total body (TBF), adipose tissue (VAT), hepatic triglyceride content (HTGC) in middle-age men women.
Abstract Hypercoagulability is characterized by abnormal elevations of coagulation factor levels and increased thrombin generation potential. Prior studies demonstrated links between impaired glucose metabolism, endothelial dysfunction, hypercoagulability. However, the associations hypercoagulability incident type 2 diabetes as well its underlying mechanism remain unclear. We aimed to assess parameters including (F) VIII, FIX, FXI, fibrinogen, potential (lag time, endogenous [ETP], peak,...
Visceral adipose tissue (VAT) and hepatic triglyceride content (HTGC) are major risk factors for cardiometabolic diseases.We aimed to investigate the association of dietary intake main food groups with VAT HTGC in middle-aged men women.We used data from Netherlands Epidemiology Obesity study, a population-based study including 6671 participants aged 45-65 y at baseline. In this cross-sectional analysis, were assessed by magnetic resonance imaging spectroscopy, respectively, as primary...
The antioxidant vitamin E (α-tocopherol, α-TOH) protects lipids from oxidation by reactive oxygen species. We hypothesized that lifestyle factors associate with metabolism marked urinary α-tocopheronolactone hydroquinone (α-TLHQ) and α-carboxymethyl-hydroxychroman (α-CEHC levels), as potential reflection of lipid oxidation. conducted a cross-sectional study in the Netherlands Epidemiology Obesity Study. Serum α-TOH, α-TLHQ α-CEHC were quantified liquid chromatography coupled tandem mass...
It is unclear to what extent adherence dietary guidelines may specifically affect visceral fat and liver fat. We aimed study the association between Dutch Healthy Diet Index (DHD-index) total body fat, adipose tissue (VAT) hepatic triglyceride content (HTGC) in middle-aged men women.In this cross-sectional study, VAT was assessed by magnetic resonance imaging (MRI) 2580 participants, HTGC proton-MR spectroscopy 2083 participants. Habitual intake physical activity were estimated...