A5076548246- RNA modifications and cancer
- Fungal and yeast genetics research
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Bacterial Genetics and Biotechnology
- Mass Spectrometry Techniques and Applications
- RNA and protein synthesis mechanisms
- Signaling Pathways in Disease
- Plant nutrient uptake and metabolism
- Cell death mechanisms and regulation
- Advanced Vision and Imaging
- Ion-surface interactions and analysis
- Cancer-related gene regulation
- Medical Image Segmentation Techniques
- Cancer-related molecular mechanisms research
- Analytical Chemistry and Chromatography
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Photosynthetic Processes and Mechanisms
- Computer Graphics and Visualization Techniques
- Cancer, Lipids, and Metabolism
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Shanghai Jiao Tong University
2025
Fudan University
2014-2024
State Key Laboratory of Genetic Engineering
2011-2023
Nanjing Maternity and Child Health Care Hospital
2023
Nanjing Medical University
2014-2023
Zhejiang Normal University
2022
Zhongshan Hospital
2015-2020
Beijing Tian Tan Hospital
2014
Septins, a conserved family of cytoskeletal GTP‐binding proteins, were presented in diverse eukaryotes. Here, comprehensive phylogenetic and evolutionary analysis for septin proteins metazoan was carried out. First, we demonstrated that all could be clustered into four subgroups, the representative homologue every subgroup non‐vertebrate chordate Ciona intestinalis , indicating emergence subgroups should have occurred prior to divergence vertebrates invertebrates, expansion gene number...
Human carbonyl reductase 1 (CBR1) converts the antitumor drug and anthracycline daunorubicin (DNR) into alcohol metabolite daunorubicinol (DNROL) with significantly reduced activity cardiotoxicity, this limits clinical use of DNR. Inhibition CBR1 can thus increase efficacy decrease toxicity Here we report that (−)-epigallocatechin gallate (EGCG) from green tea is a promising inhibitor CBR1. EGCG directly interacts acts as noncompetitive respect to cofactor nicotinamide adenine dinucleotide...
Increasing evidence has indicated that microRNAs (miRNAs) are strongly implicated in the initiation and progression of glioblastoma multiforme (GBM). Here, we identified a novel tumor suppressive miRNA, miR-377, investigated its role therapeutic effect for GBM. MiRNA global screening was performed on GBM patient samples adjacent nontumor brain tissues. The expression miR-377 detected by real-time reverse-transcription PCR. effects cell proliferation, cycle progression, invasion, orthotopic...
Mesoporous silica nanoparticles (MSN) have been widely applied for drug delivery systems. To investigate the effects of pore size on anticancer efficacies, MSN with different sizes but similar particle and surface charges were synthesized via a microemulsion method. The structures characterized by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), N2 adsorption-desorption isotherms. Doxorubicin loaded (DOX/MSN) prepared minimum loading capacity was detected in...
Activation of β-catenin, the central effector canonical wingless-type (Wnt) pathway, has been implicated in hepatocellular carcinoma (HCC). However, transcription regulation mechanism β-catenin gene HCC remains unknown. Here we report that human zinc finger protein 191 (ZNF191) is a potential regulator transcription. ZNF191, Krüppel-like protein, specifically interacts with TCAT motif, which constitutes HUMTH01 microsatellite tyrosine hydroxylase ( TH ) ex vivo . We demonstrate ZNF191...
PARP12 is a mono-ADP-ribosyltransferase, but its function remains largely unknown. Here, we identified four-and-a-half LIM-only protein 2 (FHL2) as functional partner of through affinity purification. Although did not mono-ADP-ribosylate FHL2 in vitro and vivo, deficiency decreased the level by promoting ubiquitination increased expression transforming growth factor beta1 (TGF-β1), which independent enzymatic activity. We also provided evidence that migration invasion hepatocellular...
Most cancer causal variants are found in gene regulatory elements, e.g., enhancers. However, enhancer predisposing to hepatocellular carcinoma (HCC) remain unreported. Here we conduct a genome-wide survey of HCC-susceptible through three-stage association study 11,958 individuals and identify rs73613962 (T > G) within the intronic region PRMT7 at 16q22.1 as susceptibility locus HCC (OR = 1.41, P 6.02 × 10-10). An dual-luciferase assay indicates that rs73613962-harboring has allele-specific...
Genetically engineered bacteria represent a promising drug delivery tool for disease treatment. The development of new strategies specific and independent protein regulation is necessary, especially combination therapy. Using the well-studied Escherichia coli phage λ as model system, we applied noncanonical amino acids (ncAAs) novel inducers in bacteria-based system. Screening permissive sites Cro revealed that incorporation AlocK at K8 site with MbPylRS-349F/tRNAPyl system produced...
Dendritic cells (DCs) are important for the initiation of adaptive immune response against Mycobacterium tuberculosis. Autophagy is an innate and defense mechanism control M. However, role autophagy in tuberculosis remains to be determined. In present study, we studied effects on maturation DCs infected with Bacillus Calmette- Guerin (BCG). The phenotype function were assessed by measuring expression CD86 HLA-DR secretion IL-10 IL-6. was evaluated change LC3II, a molecular marker autophagy....
Tumor angiogenesis is one of the hallmarks cancer as well an attractive target for therapy. Characterization novel pathways that act in parallel with VEGF/VEGFR axis to promote tumor may provide insights into anti-angiogenic therapeutic targets. We found expression level Nogo-B positively correlated vessel density hepatocellular carcinoma (HCC). While depletion inhibited angiogenesis, overexpression promoted a xenograft subcutaneous model human HCC cell line. Mechanically, regulates based on...
Aurora-A is a serine/threonine kinase, which overexpressed in multiple human cancers and plays key role tumorigenesis tumor development. In this study, we found that the receptor of activated C-kinase1 (RACK1), an important regulator biological functions, interacted with co-localized at centrosomes. Moreover, RACK1 induces auto-phosphorylation vitro vivo. Depletion impaired activation late G2 phase, then inhibited mitotic entry leaded to multi-polarity, severe chromosome alignment defects,...