Michael Maiwald

ORCID: 0000-0003-4309-728X
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About
Contact & Profiles
Research Areas
  • NMR spectroscopy and applications
  • Spectroscopy and Chemometric Analyses
  • Analytical Chemistry and Chromatography
  • Advanced NMR Techniques and Applications
  • Advanced MRI Techniques and Applications
  • Advanced Chemical Sensor Technologies
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Microfluidic and Capillary Electrophoresis Applications
  • Fault Detection and Control Systems
  • Digital Innovation in Industries
  • Metabolomics and Mass Spectrometry Studies
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Flexible and Reconfigurable Manufacturing Systems
  • Crystallization and Solubility Studies
  • Scientific Measurement and Uncertainty Evaluation
  • Phase Equilibria and Thermodynamics
  • Chemical Thermodynamics and Molecular Structure
  • X-ray Diffraction in Crystallography
  • Advanced Control Systems Optimization
  • Analytical chemistry methods development
  • Catalysis and Oxidation Reactions
  • Carbon Dioxide Capture Technologies
  • Healthcare Technology and Patient Monitoring
  • Various Chemistry Research Topics
  • Physics and Engineering Research Articles

Federal Institute For Materials Research and Testing
2016-2025

Hydrogenics (Belgium)
2023

Bluegrass Advanced Materials (United States)
2020

Software (Spain)
2020

University of Stuttgart
1999-2008

Merck (Germany)
2006-2008

University of Kaiserslautern
2002

Ruhr University Bochum
1995-1998

Norwich Research Park
1997

John Innes Centre
1997

10.1016/j.trac.2016.03.016 article EN TrAC Trends in Analytical Chemistry 2016-03-19

Modular plants using intensified continuous processes represent an appealing concept for the production of pharmaceuticals. It can improve quality, safety, sustainability, and profitability compared to batch processes; besides, it enables plug-and-produce reconfiguration fast product changes. To facilitate this flexibility by real-time quality control, we developed a solution that be adapted quickly new is based on compact nuclear magnetic resonance (NMR) spectrometer. The NMR sensor...

10.1007/s00216-019-01752-y article EN cc-by Analytical and Bioanalytical Chemistry 2019-03-23

Abstract Complex processes meet and need Industry 4.0 capabilities. Shorter product cycles, flexible production needs, direct assessment of quality attributes raw material call for an increased new process analytical technologies (PAT) concepts. While individual PAT tools may be available since decades, we holistic concepts to fulfill above industrial needs. In this series two contributions, want present a combined view on the future (process technology), which is projected in smart labs...

10.1007/s00216-020-02421-1 article EN cc-by Analytical and Bioanalytical Chemistry 2020-02-14

We report the scale-up of a batch solid synthesis zeolitic imidazolate framework-8 (ZIF-8) for reactive extrusion. The crystalline product forms in extruder directly under mixture 2-methylimidazole and basic zinc carbonate presence catalytic amount liquid. process parameters such as temperature, liquid type, feeding rate, linker excess were optimized using setup specifically designed situ Raman spectroscopy. Highly ZIF-8 with Brunauer–Emmett–Teller (BET) surface area 1816 m2 g–1 was...

10.1021/acssuschemeng.2c07509 article EN ACS Sustainable Chemistry & Engineering 2023-03-21

Abstract Industry 4.0 is all about interconnectivity, sensor-enhanced process control, and data-driven systems. Process analytical technology (PAT) such as online nuclear magnetic resonance (NMR) spectroscopy gaining in importance, it increasingly contributes to automation digitalization production. In many cases up now, however, a classical evaluation of data their transformation into knowledge not possible or economical due the insufficiently large datasets available. When developing an...

10.1007/s00216-020-02687-5 article EN cc-by Analytical and Bioanalytical Chemistry 2020-05-09

Quantitative 13C NMR spectroscopy was used to investigate the complex chemical equilibria in ternary liquid mixtures of formaldehyde−water−methanol at temperatures between 298 and 383 K. In these mixtures, formaldehyde is predominantly bound methylene glycol, poly(oxymethylene) glycols, hemiformal, hemiformals, which are formed by a series oligomerization reactions. The present study first data on species distribution studied technically important system reported. It complements previous...

10.1021/ie0203072 article EN Industrial & Engineering Chemistry Research 2002-12-13

Quantitative online nuclear magnetic resonance (NMR) spectroscopy was used to study the species distribution in solutions of carbon dioxide (CO2) aqueous N-methyldiethanolamine (MDEA), and MDEA + piperazine (PIP). The mass fraction unloaded ternary solution 0.2, 0.3, 0.4 g/g. In quaternary solutions, 0.3 g/g, that PIP 0.1 temperature ranged from 293 K 333 K, overall CO2 loading up 1.4 molCO2/molamine. For measurements, a special apparatus allowed mixtures be prepared gravimetrically applied...

10.1021/ie800914m article EN Industrial & Engineering Chemistry Research 2008-09-24

Abstract The competitiveness of the chemical and pharmaceutical industry is based on ensuring required product quality while making optimum use plants, raw materials, energy. In this context, effective process control using reliable analytics secures global competitiveness. setup those strategies often originate in development but need to be transferable along whole life cycle. series two contributions, we want present a combined view future PAT (process analytical technology), which...

10.1007/s00216-020-02420-2 article EN cc-by Analytical and Bioanalytical Chemistry 2020-02-15

Abstract Online NMR spectroscopy is an excellent tool to study complex reacting multicomponent mixtures and gain process insight understanding. For online studies under conditions, flow probes can be used in a wide range of temperature pressure. This paper compiles the most important aspects towards quantitative provides examples. After introduced as method for technical samples without sample preparation deuterated solvents, influences residence time distribution, pre‐magnetization, cell...

10.1002/cite.201500120 article EN Chemie Ingenieur Technik 2016-03-02

Medium-resolution nuclear magnetic resonance spectroscopy (MR-NMR) currently develops to an important analytical tool for both quality control and process monitoring. In contrast high-resolution online NMR (HR-NMR), MR-NMR can be operated under rough environmental conditions. A continuous re-circulating stream of reaction mixture from the vessel spectrometer enables a non-invasive, volume integrating analysis reactants products. Here, we investigate esterification 2,2,2-trifluoroethanol with...

10.1002/mrc.4216 article EN Magnetic Resonance in Chemistry 2015-04-09

NMR is a powerful analytical technique that combines an exquisite qualitative power, related to the unicity of spectra each molecule in mixture, with intrinsic quantitativeness, fact integral peak only depends on number nuclei (i.e., amount substance times equivalent signal), regardless molecule. Signal integration most common approach quantitative but has several drawbacks (vide infra). An alternative use hard modeling peaks. In this paper, we present pyIHM, Python package for...

10.1021/acs.analchem.4c06484 article EN cc-by Analytical Chemistry 2025-02-24

To obtain information on the adoption of self-measurement blood pressure by hypertensives and their attending physicians.Callers to Cardiovascular Hotline Heidelberg revealing themselves have high were interviewed about self-recording pressure.Among callers 70% practised self-measurement. Half them bought a device own initiative, one-third recommendation or prescription physician. A quarter those practising technique introduced it experienced personnel comparable number adequately informed...

10.1097/00004872-199603000-00008 article EN Journal of Hypertension 1996-03-01
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