Barbara M. Geubels
A5023925120- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- Chemotherapy-induced organ toxicity mitigation
- Advanced Radiotherapy Techniques
- Chemotherapy-induced cardiotoxicity and mitigation
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Clinical practice guidelines implementation
- Pharmacological Effects and Toxicity Studies
- Cancer Treatment and Pharmacology
- Patient-Provider Communication in Healthcare
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Anorectal Disease Treatments and Outcomes
Maastricht University
2021-2025
Catharina Ziekenhuis
2021-2025
Radboud University Nijmegen
2021-2025
The Netherlands Cancer Institute
2021-2025
Center for Human Reproduction
2023
University Medical Center Groningen
2012-2015
University of Groningen
2015
Abstract Background In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is lack of consensus on the definition management near-cCR. This study aimed to compare outcomes in who achieved at first reassessment versus later reassessment. Methods registry included from International Watch & Wait Database. Patients were categorized as having or (that near-cCR reassessment) based MRI endoscopy. Organ preservation,...
BackgroundThe success of cisplatin-based (Platinol, Bristol-Myers Squibb Company, New York, NY, USA) chemotherapy for testicular cancer comes at the price long-term and late effects related to healthy tissue damage. We assessed modelled serum platinum (Pt) decay after determined relationships between circulating Pt levels known effects.Patients methodsIn 99 survivors, treated with chemotherapy, 24-h urine samples were collected during follow-up (1–13 years treatment). To build a population...
PURPOSE Organ preservation has become an attractive alternative to surgery (total mesorectal excision [TME]) among patients with rectal cancer after neoadjuvant therapy who achieve a clinical complete response (cCR). Nearly 30% of these will develop local regrowth (LR). Although salvage resection is frequently feasible, there may be increased risk for development subsequent distant metastases (DM). The aim this study compare the DM between LR Watch and Wait (WW) near-complete pathologic...
Abstract Introduction Most reports on the outcome of Watch-and-Wait (W&W) in rectal cancer come from expert centres. This study a broad implementation Netherlands. Material and Methods The process W&W is described patients registry between 2004 2022 analysed (regrowth, metastases, survival, organ preservation). Three equally sized chronological cohorts were compared to capture any differences during over time. Results was gradually implemented 18 high-volume hospitals coordinated by...
Young-onset rectal cancer, in patients less than 50 years, is expected to increase the coming years. A watch-and-wait strategy nowadays increasingly practised with a clinical complete response (cCR) after neoadjuvant treatment. Nevertheless, there may be reluctance offer organ preservation treatment young owing potentially higher oncological risk. This study compared aged years those or more identify possible differences outcomes of watch and wait.The analysed data from cCR therapy whom...
Journal Article Outcomes of watch and wait after short-course radiotherapy in an international multicentre watch-and-wait cohort Get access Barbara M Geubels, Geubels Department Surgery, Netherlands Cancer Institute, Amsterdam, The NetherlandsDepartment Catharina Hospital, Eindhoven, NetherlandsGROW School for Oncology Reproduction, Maastricht University, Maastricht, Search other works by this author on: Oxford Academic Google Scholar Aart-Jan van den Esschert, Esschert Sofieke J D Temmink,...
Rectal cancer patients with a clinical complete response to neoadjuvant (chemo)radiation are eligible for Watch and Wait (W&W). For local regrowth, total mesorectal excision (TME) is considered the standard of care. This study evaluated (LE) suspected regrowth. From 591 prospectively entered into national W&W registry, 77 LE regrowth were included. Outcomes analyzed included histopathologic findings, locoregional recurrence, long-term organ preservation, colostomy-free overall survival. In...
Total mesorectal excision for rectal cancer is a major operation associated with morbidity and mortality. For older or inoperable patients, alternatives are necessary. This prospective study evaluated the oncological functional outcome quality of life patients treated contact X-ray brachytherapy boost to avoid surgery. During follow-up, tumor response toxicity on endoscopy were scored. Functional assessed self-administered questionnaires. Additionally, in-depth interviews regarding patients'...
Introduction Standard treatment for patients with intermediate or locally advanced rectal cancer is (chemo)radiotherapy followed by total mesorectal excision (TME) surgery. In recent years, organ preservation aiming at improving quality of life has been explored. Patients a complete clinical response to can be managed safely watch-and-wait approach. However, the optimal organ-preserving strategy good, but not remains unclear. The aim OPAXX study determine rate that achieved in good after...
For nodal regrowth in patients with rectal cancer following watch-and-wait standardized protocols on diagnostic procedures and subsequent treatment are lacking.
4528 Background: Successful platinum(Pt)-based chemotherapy for testicular cancer (TC) comes at the price of late cardiovascular morbidity and neurotoxicity. Damage induced by circulating Pt could be an etiological mechanism. We investigated relation between effects. Methods: In 96 consecutive TC patients (med age 29 [17-53] chemotherapy), 3 serum samples a 24h-urine sample were collected on several time-points med 5 yrs (1-13) after treatment. concentrations ([Pt]) measured with sensitive...