A5083630398- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Ginger and Zingiberaceae research
- Protein purification and stability
- Gut microbiota and health
- Traditional Chinese Medicine Studies
- Nanoparticle-Based Drug Delivery
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Signaling Pathways in Disease
- Drug Transport and Resistance Mechanisms
- Adipose Tissue and Metabolism
- Iron Metabolism and Disorders
- Probiotics and Fermented Foods
- Glutathione Transferases and Polymorphisms
- Ginseng Biological Effects and Applications
- Helicobacter pylori-related gastroenterology studies
- Synthesis and biological activity
- Acupuncture Treatment Research Studies
Sichuan University
2012-2024
Hunan University of Traditional Chinese Medicine
2017-2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Shandong University of Traditional Chinese Medicine
2023
Nanjing Medical University
2022
Jiangsu Province Hospital
2022
Peking University
2021-2022
Wenzhou Medical University
2012-2019
First Affiliated Hospital of Wenzhou Medical University
2012-2019
The Seventh Affiliated Hospital of Sun Yat-sen University
2019
Mitogen-activated protein kinase (MAPK) cascades are activated by diverse extracellular signals and participate in the regulation of an array cellular programs. In this study, we investigated roles MAPKs induction phase II detoxifying enzymes chemicals. Treatment human hepatoma (HepG2) murine (Hepa1c1c7) cells withtert-butylhydroquinone (tBHQ) or sulforaphane (SUL), two potent enzyme inducers, stimulated activity signal-regulated 2 (ERK2) but not c-Jun N-terminal 1. tBHQ SUL also MAPK...
Phase II drug-metabolizing enzymes, such as glutathione <i>S</i>-transferase and quinone reductase, play an important role in the detoxification of chemical carcinogens. The induction these detoxifying enzymes by a variety agents occurs at transcriptional level is regulated <i>cis</i>-acting element, called antioxidant response element (ARE) or electrophile-response element. In this study, we identified signaling kinase pathway that negatively regulates ARE-mediated gene expression....
The COVID-19 global epidemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a great public health emergency. Discovering antiviral drug candidates urgent for the prevention and treatment of COVID-19. This work aims to discover natural SARS-CoV-2 inhibitors from traditional Chinese herbal medicine licorice. We screened 125 small molecules Glycyrrhiza uralensis Fisch. (licorice, Gan-Cao) virtual ligand screening targeting receptor-binding domain (RBD) spike protein....
Poor delivery of insoluble anticancer drugs has so far precluded their clinical application. In this study, we developed a tumor-targeting system for drug (paclitaxel, PTX) by PEGylated O-carboxymethyl-chitosan (CMC) nanoparticles grafted with cyclic Arg-Gly-Asp (RGD) peptide. To improve the loading efficiency (LE), combined O/W/O double emulsion method temperature-programmed solidification technique and controlled PTX within matrix network as in situ nanocrystallite form. Furthermore, these...
Nanoparticles based on the heavy chain of human ferritin (HFn) are arousing growing interest in field drug delivery due to their exceptional characteristics. However, unsatisfied plasma half life HFn substantially limits its application as a platform for antitumor agents. Herein we fused an albumin binding domain (ABD) variant that basically derives from streptococcal protein G and possesses long-acting characteristic serum N-terminus aim half-life extension. This ABD-HFn construct was...
Summary Although plant secondary metabolites are important source of new drugs, obtaining these compounds is challenging due to their high structural diversity and low abundance. The roots Astragalus membranaceus a popular herbal medicine worldwide. It contains series cycloartane‐type saponins (astragalosides) as hepatoprotective antivirus components. However, astragalosides exhibit complex sugar substitution patterns which hindered purification bioactivity investigation. In this work,...
Hepatic steatosis, a hallmark of non-alcoholic fatty liver disease (NAFLD), represents significant global health issue. Liver lipidomics has garnered increased focus recently, highlighting Traditional Chinese Medicine's (TCM) role in mitigating such conditions through lipid metabolism regulation. The Zuogui Jiangtang Qinggan Formula (ZGJTQGF), longstanding TCM regimen for treating Type 2 Diabetes Mellitus (T2DM) with NAFLD, lacks definitive mechanism its regulatory effects.
Non-alcoholic fatty liver disease (NAFLD) represents a significant global health burden, exhibiting strong correlation with insulin resistance, obesity, and type 2 diabetes (T2DM). Despite the severity of hepatic steatosis in T2DM patients, no specific drugs have been approved for clinical treatment disease. Tangerine peel is one kind popular functional food reported to possess hypoglycemic lipid-lowering potential. In this study, we investigated effects Tangerine-peel-derived exosome-like...
Butylated hydroxyanisole (BHA), a commonly used food preservative, is reported to have anticarcinogenic properties in some animal models. However, the use of BHA as chemopreventive agent against cancer human has been challenged by observation that may exert toxic effect tissues animals. Therefore, it great significance understand mechanism BHA-induced toxicity. Here, we report induces apoptosis freshly isolated rat hepatocytes. Treatment hepatocytes with also induced loss mitochondrial...
The interplay between phase II enzymes and efflux transporters leads to extensive metabolism low bioavailability for flavonoids. To investigate the simplest one UDP-glucuronosyltransferase isoform transporter in flavonoid disposition, engineered HeLa cells stably overexpressing UGT1A9 were developed, characterized, further applied of two model flavonoids (genistein apigenin) excretion their glucuronides. results indicated that rapidly excreted glucuronides genistein apigenin. kinetic...
Objective To compare the efficacy of three protocols for ovarian stimulation in patients with diminished reserve during vitro fertilization (IVF) treatment. Methods This prospective randomized study enrolled who underwent cycles IVF or intracytoplasmic sperm injection. The were randomly divided into groups: a modified gonadotrophin releasing hormone (GnRH) agonist protocol (group A); (ii) mild B); (iii) an antagonist C). Demographic characteristics, clinical variables and pregnancy outcomes...
The current research tried to explore the effect of Qiweibaizhu powder (QWBZP) on bacterial diversity and community structure intestinal mucosa dysbiosis diarrhea mice provide a scientific basis for efficacy QWBZP antibiotic-induced diarrhea. A mouse model was constructed with broad-spectrum antibiotics through mixture cephradine capsules gentamicin sulfate (23.33 mL·kg -1 ·d ). Intestinal collected, DNA extracted from each group. characteristics in were analyzed by MiSeq sequencing based...
This study explored the association between oral microbes and head neck cancer (HNC) as well symptoms related to patients with HNC before surgical treatment. Fifty-six 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, symptom data collected. Salivary samples collected determine microbial characteristics using 16S rRNA gene sequencing. Patients presented increased Capnocytophaga abundances. markers (area under curve=0.81)...
Cocaine is a widely abused drug. Recently, it has been shown to induce teratogenesis in both humans and animals. Cocaine-induced teratogenicity associated with reactive oxygen species (ROS), which are generated by cytochrome P450 during cocaine biotransformation. Since ROS have reported genotoxicity, of interest know whether and/or its metabolites also genotoxic. In this study, Chinese hamster ovary K1 cells were employed as model system investigate the genetic toxicity presence or absence...