A5043165756- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Hemoglobin structure and function
- Ethnobotanical and Medicinal Plants Studies
- Natural Antidiabetic Agents Studies
- Sesquiterpenes and Asteraceae Studies
- African Botany and Ecology Studies
- Traditional and Medicinal Uses of Annonaceae
- HIV-related health complications and treatments
- Neonatal Health and Biochemistry
- Moringa oleifera research and applications
- Phytochemical compounds biological activities
- Trypanosoma species research and implications
- Air Quality and Health Impacts
- Phytochemicals and Antioxidant Activities
- Folate and B Vitamins Research
- Cassava research and cyanide
- Phytochemistry and Bioactivity Studies
- Insect Pest Control Strategies
- Plant chemical constituents analysis
- Phytochemistry and Bioactive Compounds
- Biological Activity of Diterpenoids and Biflavonoids
Université de Dschang
2016-2025
Inserm
2024
Université de Montpellier
2024
Laboratoire de Biochimie
2016
Trachyspermum ammi (Apiaceae) is a plant with good reputation in the traditional Persian and Ayurvedic medicine. The hydrodistilled essential oil from fruits of T. ammi, known as 'ajwain oil', used countries such Iraq, Iran, Afghanistan, Pakistan, India preparation curry, to flavour several foods, preservative, perfumery. At therapeutic level, ajwain employed treatment gastrointestinal ailments, lack appetite bronchial problems. In present work, growing Iran was analysed by GC–FID GC–MS...
Studies demonstrate that free radicals are involved in the pathogenesis of diabetic complications. The aim this study was to determine implication total antioxidant capacity (TAC) and some enzymatic non-enzymatic antioxidants as suitable biomarkers complications risk factors. A 90 patients (70 with or without +20 normal healthy) were examined by evaluating level lipid peroxidation, nitrogen monoxide (NO), fasting blood glucose, glycated haemoglobin (HbA1c), using standard spectrophotometric...
Essential oils are complex mixtures of volatile components produced by the plant secondary metabolism and consist mainly monoterpenes sesquiterpenes and, to a minor extent, aromatic aliphatic compounds. They exploited in several fields such as perfumery, food, pharmaceutics, cosmetics. have long-standing uses treatment infectious diseases parasitosis humans animals. In this regard, their therapeutic potential against human African trypanosomiasis (HAT) has not been fully explored. present...
Cardiovascular diseases (CVD) and metabolic alterations are among the majors public health concern that have been reported in people living with HIV infections. Factors contributing to cardio syndrome include body fat distribution, dyslipidemia, insulin resistance, cardiovascular dysfunction inflammation. The aim of study was determine effect Spirulina platensis (Cyanobacteriaceae) supplementation versus local diet on lipid profile HIV-infected antiretroviral-naive patients. A prospective...
The aim of the present study was to investigate antioxidant activity and protective potential T. tetraptera extracts against ion toxicity. investigated spectrophotometrically several radicals (1,1-diphenyl-2-picrylhydrazyl (DPPH • ), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS hydroxyl radical (HO nitric oxide (NO )), followed by ferric reducing power, total phenols, flavonoid, flavonol contents. effects on catalase (CAT), superoxide dismutase (SOD), peroxidase activities...
Sickle Cell Disease is a chronic inflammatory disease that could be aggravated by exposure to variable factors such as infections, hemolysis, oxidative stress and so forth. preciptate acute or end-organ manifestation. However, the degree of inflammation vary in individuals. Thus this study evaluates state (hs-CRP, IL6, ferritin) children living with SCD associated factors. We conducted an analytical cross-sectional for 03 months. The patients included were those from Central Hospital Yaounde...
Henna leaves are the raw material of commercial body and hair dyes.According to historical ethnobotanical information, henna was one first plants used for such purpose.However, differences can be observed between products by origin material, presence other plants, or addition various contaminants that may cause allergies permanent scarring.Nowadays is everywhere but it lacks necessary controls.We report a pharmacognostic study focused on quality control henna's materials from different...
Spirulina platensis produced in Nomayos (Cameroon) is used as a dietary supplement. S. known neutraceutical with many beneficial effects on humans like lipid-lowering action. This study aims to investigate the mechanism of hypolipidemic action aqueous extract (S. platensis) through toxicological studies. In this study, we included two month old Wistar rats, weighing between 180 and 200 g. Aqueous was extracted prepared using standard methods. The rats received supplementation at 5000 mg/Kg...
Anemia is a condition that has multiple origins. One such origin the destruction of red blood cells' (RBCs) membrane induced by free radicals. Treatment anemia could therefore be enhanced use radicals' scavengers potentially found in some medicinal plants. In this study, protective effect Harungana madagascariensis on RBCs' physiology was investigated vitro and vivo.In hemolytic incubation fresh human RBCs with carbontetrachloride (CCl4) Olive oil (Oo). Relaxation times protons excited at 20...
Several studies described the phytochemical constituents of plants in relation with free radical scavenging property and inhibition lipid peroxidation. This study investigated vitro antioxidant property, protective effects ethanolic aqueous ethanol extract leaves barks Afrostyrax lepidophyllus (Huaceae) against ion mediated oxidative damages.
Under oxidative stress conditions, endogenous antioxidant defenses are unable to completely inactivate the free radicals generated by an excessive production of reactive oxygen species (ROS). This state causes serious cell damage leading a variety human diseases. Natural antioxidants can protect cells against stress. Hypaodaphnis zenkeri (H. zenkiri) is plant consumed as spice in Cameroonian diet, and its bark has been used traditional medicine for treatment several The present study aims at...
Sickle cell anemia (SCA) or sickle disease (SCD) is a genetic associated with increased morbidity and mortality in Africa other developing nations. Therefore, modern traditional remedies are being introduced for use the treatment management of this disease. This because safe, effective, inexpensive therapeutic agents urgently needed
Liver diseases are a global health problem. Medicinal plants being increasingly used to manage wide variety of including liver disorders. The aim this study was investigate the antioxidant properties and hepatoprotective activity polyphenolic extract from fruits Tetrapleura tetraptera (T. tetraptera).The T. administered at doses 50 mg/kg 100 for 07 per os rats before induction hepatotoxicity with 2 ml/kg 1:1 (v/v) carbon tetrachloride (CCl4) olive oil through intraperitoneal route. in vitro...
Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and one of the major risk factors for cardiovascular diseases induced by oxidative stress Africa. The aim this research was to investigate correlation between higher atherogenic index plasma (API) a group living with SCA Cameroon.
Reactive oxygen species (ROS), products of normal cell metabolism may cause damage to biological macromolecules leading severe health threats when they are present in high concentrations. Aromatic plants contain phytochemicals rich antioxidants that prevent oxidant formation or scavenge oxidants produced under oxidative stress conditions. In the study, we investigated free radical scavenging effects, antioxidant and ion toxicity preventive effect Xylopia aethiopica (X. aethiopica), a plant...
Abstract Objective The haptoglobin (Hp) gene located on chromosome 16q22 exhibits a polymorphism that can impact its capacity to inhibit the deleterious oxidative activity of free hemoglobin. We aimed determine influence Hp stress, lipid profile, and cardiovascular risk in Cameroonian sickle cell anemia patients (SCA patients). Method genotypes 102 SCA (SS), 60 healthy individuals (AA), 55 subjects with trait (AS) were determined by allele‐specific PCR, blood parameters assessed using...
Tuberculosis (TB) is a worldwide public health problem. It contagious and grave disease caused by Mycobacterium tuberculosis. Current drugs such as isoniazid, pyrazinamide, rifampicin used for the treatment of tuberculosis are potentially hepatotoxic can lead to drug hepatitis. In order improve follow-up TB patients in Cameroon, we carried out study which aimed evaluate hepatotoxicity risk factors associated with anti-TB drugs. The studies were performed on 75 participants who had visited...
Background and objectives: sickle cell disease is the most common hemoglobinopathy in world. It considered to be a real public health problem. Sickle patients are subjected several factors causing inflammation such as iron metabolism. The study aimed look for children with Cameroon, identify associated inflammation, raise consequences patient including profile of hemogram. Materials methods: We conducted an analytical cross-sectional 03 months. coming and/or followed at Hematology Department...
Recent studies releaved that the high production of reactive oxidative species due to exposure fine or ultrafine particles are implicated in many chronical respiratory disorders. However, poor standard clinical data sub-Saharan countries makes very difficult assessment knowledge air pollution health impact urban cities. Objective: aim this study was evaluate distribution disorders associated and through changes some stress biomarkers among motorbike drivers from two cities Cameroon Methods:...
Haptoglobin (HP) is a liver glycoprotein that actively synthesized during inflammatory and hemolytic processes. It also has pro-oxidant proinflammatory properties, which are function of its genotype. The genetic polymorphism the chains leads to synthesis three phenotypes/proteins, related number type their molecular weight, namely HP1-1, HP1-2 HP2-2. Patients with HP2-2 have more vascular complications, while those HP1-1 fewer. HP involved in worsening diseases, such as aggravation...
Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in the Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In present study we evaluated vitro biological activities displayed by essential oil obtained from aerial parts E. floribundus, namely antioxidant, antimicrobial antiproliferative activities. Moreover, investigated inhibitory effects on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for...