A5072596819- SARS-CoV-2 and COVID-19 Research
- Helminth infection and control
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Parasite Biology and Host Interactions
- Healthcare during COVID-19 Pandemic
- Coccidia and coccidiosis research
- Parasites and Host Interactions
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Healthcare Regulation
- Colorectal and Anal Carcinomas
- Mollusks and Parasites Studies
- Animal Virus Infections Studies
- Biosensors and Analytical Detection
- Colorectal Cancer Treatments and Studies
- COVID-19 and healthcare impacts
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Child Nutrition and Water Access
- Long-Term Effects of COVID-19
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Viral gastroenteritis research and epidemiology
Fundação Oswaldo Cruz
2014-2024
Michigan State University
2023
Universidade Federal de Minas Gerais
2023
Ministério da Saúde
2017
The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number mutations when compared other variants, brought light concern about vaccine escape, especially from neutralization by antibodies induced vaccination.Based on viral microneutralization assays, we evaluated in 90 individuals impact antibody induction, against booster dose BNT162b2 mRNA after CoronaVac primary vaccination scheme.Here show that percentage seroconverted 30 and 60 days scheme was 16.6% 10%,...
Prior to eliminating schistosomiasis, efforts must address accurate and fast individual diagnosis. Diagnosis is still inaccurate by parasitological point-of-care circulating cathodic antigen (POC-CCA) in areas of low endemicity. Our group has optimized POC-CCA with a 30 min urine concentration step no need for specialized technicians or equipment high accuracy. We evaluated this new method, called filter (FLT), two Brazilian endemic distinct profiles. At baseline, had poor performance...
Abstract Early diagnosis of SARS-CoV-2 is essential to limiting the spread virus and managing infected patients during hospitalization. The sensitivity RT-qPCR contested by fact that it time-consuming, executed trained technicians in proper environment for material extraction. Here, we evaluated first antigen test recommended World Health Organization at September, 2020 as an alternative immediate symptomatic suspected a hospital Brazil epidemic peak. All were submitted rapid using...
Early diagnosis of SARS-CoV-2 is essential to limiting the spread virus and managing infected patients during hospitalization. The sensitivity RT-qPCR contested by fact that it time-consuming, executed trained technicians in proper environment for material extraction. Here, we evaluated first antigen test recommended World Health Organization at September, 2020 as an alternative immediate symptomatic suspected a hospital Brazil epidemic peak. All were submitted rapid using nasopharyngeal...
SARS-CoV-2 virus originated in Wuhan (China) December (2019) and quickly spread worldwide. Antigen tests are rapid diagnostic (RDT) that produce results 15-30 min an important tool for the scale-up of COVID-19 testing. authorized self-testing at home some countries, including Brazil. Widespread testing is required to guide public health policies control speed transmission economic recovery.Patients with suspected were recruited Hospital da Baleia (Belo Horizonte, Brazil). The...
The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number mutations when compared other variants, brought light concern about vaccine escape, especially from neutralization by antibodies induced vaccination. In this scenario, we evaluated impact on antibody induction, against booster dose BNT162b2 mRNA after CoronaVac primary vaccination scheme. percentage seroconverted individuals 30 and 60 days scheme was 17% 10%, respectively. After administration,...
Introduction SARS-CoV-2 vaccines production and distribution enabled the return to normalcy worldwide, but it was not fast enough avoid emergence of variants capable evading immune response induced by prior infections vaccination. This study evaluated, against Omicron sublineages BA.1, BA.5 BQ.1.1, antibody a cohort vaccinated with two doses CoronaVac protocol followed heterologous booster doses. Methods To assess vaccination effectiveness, serum samples were collected from 160 individuals,...
La fasciolosis ha sido considerada una infección de gran importancia para la salud pública, además causar impactos en economía debido al aumento del número casos los últimos años. Es endémica Perú y Bolivia. En Brasil, enfermedad es el estado Río Grande do Sul. Estudios realizados con especímenes Fasciola hepatica diferentes regiones geográficas demuestran que las características vermes adultos huevos pueden variar acuerdo localización origen hospedero. este estudio evaluamos si estas...
INTRODUÇÃO:Durante a pandemia da COVID-19, iniciada em 2020, inúmeros foram os esforços para driblar doença e minimizar seus efeitos, principalmente por meio vacinação.Sabe-se que indivíduos submetidos à tratamentos imunossupressores, como pacientes tratamento antineoplástico ativo, necessitam serem melhor assistidos, visto eles apresentam maiores chances de desenvolver formas graves são mais susceptíveis infecção.Estudos já feitos mostraram as vacinas contra COVID-19 capazes garantir...
The COVID-19 pandemic has caused a severe global health and economic crisis, with significant consequences for human mortality morbidity. Therefore, there is an urgent need more studies on the immune response to SARS-CoV-2 infection, both enhance its effectiveness prevent deleterious effects. This study presents chronology of antibodies during six months after infection in hospitalized patients kinetics serum soluble mediators cellular triggered by SARS-CoV-2. Samples clinical data from 330...
em pacientes oncológicos tratamento de quimio e radioterápicos, descrever os níveis anticorpos totais específicos ao SARS-CoV-2 com ou sem diagnóstico COVID-19 antes da vacinação avaliar a resposta celular nesses pacientes.METODOLOGIA: O monitoramento conta
Rectal Adenocarcinoma (RA) represents more than 90% of rectal tumors, with high global incidence and mortality rates. Treatment includes neoadjuvant therapy
Control constraints of Schistosomiasis include the lack diagnostic methods with high sensitivity. We develop a prospective study in southeast Brazil to standardize new sensitive and rapid for Schistosoma mansoni infection. Currently, we are investigating 6 endemic areas (>1000 individuals chronic infection) 84 travelers infected fresh water pool (with acute infection). Sera, urine, feces saliva samples were used standardization/validation innovative methods, including acute,...
Colorectal cancer (CRC) is a heterogeneous disease. Subtyping in gene expression recognized as relevant criterion for classification of the disease, but its clinical usefulness hampered by lack standard and methodology to be used between studies analyze responsiveness each patient chemotherapeutic treatment. CXCR4 (CD184) when highly expressed generates proliferation cell survival, angiogenesis metastatic tumor migration. When CD26 less expressed, there decrease local chemokine levels,...
The molecular heterogeneity of colorectal cancer (CRC) combined with a lack methodological standard, which evaluates the effectiveness chemotherapeutic treatment, has demonstrated challenge in control disease, making it necessary to evaluate gene expression profile tumor an individualized way. Studies have shown that overexpression CXCR4 low CD26 satisfactory prognostic and treatment responsiveness. However, inverse encodes lower chance progression‐free survival evolution disease staging....
Colorectal cancer (CRC) is one of the most prevalent neoplasms and presents a multifactorial complex etiopathogenesis, not yet fully elucidated. Studies have shown that tumors right colon differ significantly from left colon, because they present greater risks metastasis, are less responsive exhibit different predictive prognostic markers. Some these markers been studied, such as tetraspanin CO029 protein, which favors cell motility, epithelial‐mesenchymal (EMT) neoplastic stem (CSC)...
Introduction:Recent studies have drawn attention to the use of gold nanoparticles (AuNPs) in immunobiological production.Ongoing efforts effective production peptide-derived monoclonal antibodies (mAbs) shown trend developing target-specific systems, which antigen is conjugated AuNPs for targeted delivery antigen-presenting cells (APCs).Several describe them as promising vehicles immunotherapy diseases such cancer, due their ability stimulate innate immunity.Thus, they play an interesting...
Introduction: After the results of phase III vaccine studies became available, leading oncology societies recommended two doses COVID-19 vaccination to all patients with cancer no specific recommendation for tumor type and active treatments.However, data on efficacy in is limited due exclusion from most clinical trials.Objective: For this reason, study proposes evaluate effectiveness against COVID19 immunosuppressed population, especially group under treatment, analyze lasting protective...
Introdução O entendimento do perfil genético tumoral, no reto, deverá contribuir nos próximos anos para a categorização dos fenótipos que mantêm resposta patológica completa.