A5026200099- Nanopore and Nanochannel Transport Studies
- Fuel Cells and Related Materials
- Ion-surface interactions and analysis
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Distributed Control Multi-Agent Systems
- Photodynamic Therapy Research Studies
- Fluid Dynamics and Heat Transfer
- Luminescence and Fluorescent Materials
- Surface Modification and Superhydrophobicity
- Advanced Control Systems Optimization
- Smart Grid Security and Resilience
- Biosensors and Analytical Detection
- Aerospace Engineering and Control Systems
- Protein Degradation and Inhibitors
- Microfluidic and Capillary Electrophoresis Applications
- Ubiquitin and proteasome pathways
- Software System Performance and Reliability
- Nanomaterials and Printing Technologies
- Carbon Nanotubes in Composites
- Porphyrin and Phthalocyanine Chemistry
- Peroxisome Proliferator-Activated Receptors
- Advanced Nanomaterials in Catalysis
- Microfluidic and Bio-sensing Technologies
Dalian Maritime University
2024-2025
College of Marin
2024
Peking University
2019-2024
Taizhou People's Hospital
2024
Nantong University
2024
Shanghai Sixth People's Hospital
2021
Jiangsu University
2015-2018
Zhanjiang Experimental Station
2017
University of Chinese Academy of Sciences
2010
The aims of this study were to detect the level histone crotonylation in prostate cancer (PCa) tissues, analyze correlations between its and clinical stage grade, explore effects bromodomain-containing protein 4 (BRD4) inhibitors sodium crotonate on PCa cell lines functions cells.PCa tissues from 72 patients adjacent 7 collected, immunohistochemistry was used measure crotonylation. Three human lines, PC-3, LNCaP, C42B, selected treated with IC50 value I-BET762, I-BET726, CPI-203,...
A30P and E46K are two mutants of α-synuclein (α-Syn) associated with familial early-onset Parkinson's disease (PD), amyloid fibrils α-Syn the hallmarks this disease. Detecting heterogeneous system in oligomerization stage is crucial for understanding fibril formation vivo toxicity oligomers. Over last decades, solid-state nanopore technology has been developed into a reliable versatile method single-molecule studies. In work, we study time-dependent kinetics early wild-type α-Syn, A30P,...
Hypoxia promotes not only the metastasis of tumors but also therapeutic resistance.
Electrical detection of single molecule based on solid‐state nanopores is recently combined with optical methods. The synergistic effect the electrical and measurements makes combination powerful. It promising for next‐generation single‐molecule approach. Conventional nanopore sensors monitor pulses caused by molecules translocating through nanopore. However, signal limited insufficient resolutions, low throughput, lack specificity, manipulation. Optical has been extensively studied since...
Post-translational modifications (PTMs), such as ubiquitination, are critically important in regulating genetic expressions by adjusting the nucleosome stability. A fast and label-free technology inspecting dynamic structures can facilitate interrogation of PTMs effects. Here we leverage advantages mechanically stable solid-state nanopores detect effect a ubiquitinated histone on mononucleosomes at single-molecule level. By comparing translocation dynamics natural cross-linked...
Discrimination of nucleotides serves as the basis for DNA sequencing using solid-state nanopores. However, translocation is usually too fast to be detected, not mention nucleotide discrimination. Here, we utilized polyphenolic TA and Fe3+, an attractive metal-organic thin film, achieved a robust surface coating silicon nitride The hydrophilic layer can greatly reduce low-frequency noise original unstable nanopore, nanopore size finely tuned in situ at nanoscale by simply adjusting relative...
In the study, a novel surface-enhanced Raman scattering (SERS)-lateral flow assay (LFA) tray for real-time detection of pyroptosis-associated miR-155-5p in breast cancer cells was established and validated. The SERS probe modified with monoclonal antibodies functionalized HP1@5-FAM first synthesized. When present, on specifically recognized target miRNAs hybridized them, resulting HP2 T line only capturing some probes that were not bound to miR-155-5p. appeared as light orange band or there...
Ferrofluids are novel functional materials that have extensively been exploited in fluid-based management and control systems, thus underlying the dynamic interactions between ferrofluid solid under various conditions is rather essential. Herein, we report an experimental investigation on impingement of millimeter-sized droplets superamphiphobic surfaces. Comparing to droplet impact no magnetic field, employment a non-uniform vertical field does not change types phenomena but alters their...
It is important to obtain the configuration of polypeptides and sequence information on amino acids for understanding various life processes many biological applications. Nanopores, as a newly developed single-molecule detection technology, exhibit unique advantages in real-time dynamics detection. Here, we designed special peptide chain with 10 arginine head achieved successful by ultrasmall solid-state nanopores (2-3 nm). Unique bidirectional translocation signals were observed explained...
The ability to detect biomolecules at the single-molecule level is forefront of biological research, precision medicine, and early diagnosis. Recently, solid-state nanopore sensors have emerged as a promising technique for label-free precise diagnosis assay. However, insufficient sensitivity selectivity small analytes are great challenge clinical applications via nanopores. Here, first time, metal-organic cage, PCC-57, employed carrier increase nanopores based on intrinsic interaction...
Abstract Herceptin (or trastuzumab) is an important therapeutic monoclonal antibody (mAb) used in the treatment of HER2‐positive breast cancer. Real‐time counting and characterization a fundamental step field disease‐related diagnosis therapy. Solid‐state nanopore‐based biosensors have been proved to hold great potential characterizing properties proteins at single‐molecule level for vitro diagnosis. Here, label‐free detection detailed translocation dynamics study using solid‐state nanopores...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Y. Chu, J. F. Lu, W. Q. Lu; Molecular Dynamics Simulation of Fluid Transport in Nanoscale Pore Porous Medium. AIP Conf. Proc. 1 March 2010; 1207 (1): 895–900. https://doi.org/10.1063/1.3366482 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar...