A5102837588- Renal Diseases and Glomerulopathies
- Prostate Cancer Treatment and Research
- Air Quality and Health Impacts
- Chronic Kidney Disease and Diabetes
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Genetic and Kidney Cyst Diseases
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Drug-Induced Adverse Reactions
- Prostate Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Multiple and Secondary Primary Cancers
- Ear Surgery and Otitis Media
- Sexual function and dysfunction studies
- Renal and related cancers
- Diabetes and associated disorders
- Health, Environment, Cognitive Aging
- Sleep and related disorders
- Genetic Syndromes and Imprinting
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Obesity, Physical Activity, Diet
- Cancer-related molecular mechanisms research
Kaiser Permanente
2016-2024
Toronto Public Health
2024
University of Southern California
2009-2016
Southern California University for Professional Studies
2016
Teva Pharmaceuticals (United States)
2014
National Taiwan University
2002-2005
Fu Jen Catholic University
2005
Cathay General Hospital
2005
China Medical University
2004
Chang Gung Memorial Hospital
2004
<h3>Rationale</h3> Exposure to ambient air pollutants has been associated with increased lung cancer incidence and mortality, but due the high case fatality rate, little is known about impacts of pollution exposures on survival after diagnosis. This study aimed determine whether pollutant are patients cancer. <h3>Methods</h3> Participants were 352 053 newly diagnosed during 1988–2009 in California, ascertained by California Cancer Registry. Average residential concentrations estimated for...
Background: Studies have shown that air pollution exposures during pregnancy are associated with an increased risk of autism spectrum disorder (ASD) in children, and the appears to be greater for boys. However, studies assessing gestational windows susceptibility been mostly limited by trimesters. Objective: We identified sensitive exposure regional ASD examined sex differences a large birth cohort. Methods: This population-based retrospective cohort study included 294,937 mother–child pairs...
Diet, obesity and adipokines play important roles in diabetes CVD; yet, limited studies have assessed the relationship between diet multiple adipokines. This cross-sectional study associations diet, adiposity Mexican Americans. The cohort included 1128 participants (age 34·7±8·2 years, BMI 29·5±5·9 kg/m2, 73·2 % female). Dietary intake was by 12-month food frequency questionnaire. Adiposity measured BMI, total percentage body fat trunk using dual-energy X-ray absorptiometry. Adiponectin,...
Modeling of visual field and pharmacy data (Kaiser Permanente, 2001 to 2014) from open-angle/pseudoexfoliation glaucoma patients in clinical practice indicated a significant inverse association between the level medication adherence rate progression.The aim was quantify effect nonadherence topical hypotensive on glaucomatous progression practice.Retrospective analysis combined Kaiser Permanente Southern California's HealthConnect electronic health record database. Patients with diagnosis...
Previous studies have reported associations between in utero exposure to regional air pollution and autism spectrum disorders (ASD). In components of near-roadway (NRAP) has been linked adverse neurodevelopment animal models, but few investigated NRAP association with ASD risk. To identify risk associated a large, representative birth cohort. This retrospective pregnancy cohort study included 314,391 mother–child pairs singletons born 2001 2014 at Kaiser Permanente Southern California (KPSC)...
The purpose of this study was to characterize the differences in myopic progression children by race/ethnicity and age.
<h3>Objective</h3> To evaluate the subjective and objective outcomes of extended uvulopalatal flap (EUPF) surgery in patients with obstructive sleep apnea. <h3>Design</h3> Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), Snore (SOS), Epworth Sleepiness Scale (ESS), polysomnography were performed preoperatively then 6 months postoperatively. <h3>Setting</h3> Tertiary care, disorders referral center. <h3>Patients</h3> Fifty-five consecutive (52 men 3 women; mean age, 45 years)...
A retrospective cohort study investigated the association between having surgery and risk of mortality for up to 5 years if this was modified by incident ESRD during follow-up period. Summary Background Data: Mortality in individuals with pre-dialysis CKD is high few effective treatment options are available. Whether bariatric can improve survival people unclear.Patients class II III obesity stages 3-5 who underwent January 1, 2006 September 30, 2015 (n = 802) were matched patients did not...
OBJECTIVE Glucokinase (GCK) and glucose-6-phosphatase catalytic subunit 2 (G6PC2) regulate the glucose-cycling step in pancreatic β-cells may insulin secretion. GCK rs1799884 G6PC2 rs560887 have been independently associated with fasting glucose, but their interaction on glucose-insulin relationships is not well characterized. RESEARCH DESIGN AND METHODS We tested whether these variants are diabetes-related quantitative traits Mexican Americans from BetaGene Study attempted to replicate our...
Abstract In 2022, more than 100 000 non‐Hodgkin lymphoma (NHL) diagnoses are expected, yet few risk factors confirmed. this study, data from six US‐based cohorts (568 717 individuals) were used to examine body size and of NHL. Over 20 years follow‐up, 11 263 NHLs identified. Hazard ratios (HRs) 95% confidence intervals (CI) estimated associations with for adult mass index (BMI), height, weight change, waist circumference predicted fat mass. Adult height was broadly associated NHL, but most...
Acute epiglottitis is a potentially disastrous disease seen occasionally in otolaryngology emergency service. This study reports our experiences managing adult patients with acute Taiwanese setting.Admission medical records from 46 over period of 8 years tertiary referral service were retrospectively reviewed.No mortality was reported; 4 (8.7%) supported by artificial airway. A total 16 (34.8%) had comorbid conditions; hypertension and diabetes mellitus the most common systemic diseases....
Developing a reliable means to identify and study real-world populations of patients with membranous nephropathy (MN) using electronic health records (EHRs) would help advance glomerular disease research. Identifying MN cases EHRs is limited by the need for manual reviews biopsy reports.
Accurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an unsolved problem. We evaluated whether DNA methylation status selected candidate genes can predict the risk metastasis beyond clinical factors in men with untreated PCa. A nested case-control study was conducted among diagnosed localized PCa Kaiser Permanente California between 01/01/1997–12/31/2006 who did not receive curative treatments. Cases were those developed within 10 years from diagnosis....
There is no consensus on how to quantify the abnormality of upper airway structures in patients with obstructive sleep apnea (OSA). This research aimed use morphological indicators as clinical predictors correlate stage and surgical results OSA patients. One hundred five received palatopharyngeal surgery, i.e. extended uvulopalatal flap (EUPF). Morphological including modified Mallampati grade (MMP), tonsil size, body mass index were used preoperatively. Change respiratory disturbance (RDI)...
Obesity and adipokines are associated with development of type 2 diabetes. However, limited longitudinal studies have examined their roles on declining β-cell function over time. This report assessed three adiposity measures (BMI, percent body fat, trunk fat), insulin resistance, fifteen in relationship to change measured by disposition index (DI) from frequently-sampled-intravenous-glucose-tolerance testing. The results showed that factors were significantly independently rate DI time: BMI...
OBJECTIVE Our goal was to investigate the correlation between upper airway 3‐dimensional computed tomography (3‐D CT) measurements and polysomnography data of patients with sleep‐disordered breathing (SDB). STUDY DESIGN AND SETTING The 3‐D CT scan retropalatal space (RP), lateral anteroposterior diameters RP, retroglossal space, uvular thickness, volume were taken prospectively from 194 consecutive SDB patients. These correlated patients' respective Respiratory Distress Index (RDI), snoring...
Objective Limited studies have assessed the relationship between longitudinal changes in adiposity and multiple adipokines over time. This study examined BMI, total body fat, trunk fat associated with 16 circulating Mexican Americans at risk for type 2 diabetes. Methods Participants included 1,213 individuals cross‐sectional data a subset of 368 follow‐up measures (mean 4.6 ± 1.5 years from baseline). Joint multivariate associations 3 were by canonical correlation analysis. Results...
Acid phosphatase locus 1 (ACP1) is a low molecular weight tyrosine that has been shown to be an important regulator of insulin receptor signaling.We tested whether variation in ACP1 associated with type 2 diabetes-related traits 1035 individuals 339 Mexican-American families probands or without previous diagnosis gestational diabetes mellitus (GDM).Study participants were phenotyped by oral glucose tolerance test (for and level) iv sensitivity acute response) had dual-energy x-ray...
We used a genome-wide discovery approach to identify methylation markers associated with metastasis in men localized prostate cancer (PCa), as better identification of those at high risk can inform treatment decision-making.
OBJECTIVE To undertake cost‐utility analysis for tympanomastoid surgery to analyze its cost‐effectiveness in treating adult chronic suppurative otitis media (CSOM). METHODS Seventy‐seven patients with CSOM were evaluated the Chronic Ear Survey (CES) before and 1 year after surgery. Direct health care cost data during 1st operation retrieved. The utility gain was defined as change CES total score. ratio (CUR) per gain. Patients stratified by disease type into wet‐ear dry‐ear groups. RESULTS...
<h3>Background</h3> DuoResp Spiromax<sup>®</sup> (Teva Pharmaceuticals) is a dry-powder inhaler designed to deliver budesonide and formoterol fumarate (BF Spiromax<sup>®</sup>) with maximum ease of use. Pharmacokinetic studies have shown bioequivalence BF Turbuhaler<sup>®</sup>. This study compared the efficacy safety these devices in patients asthma. <h3>Methods</h3> was 12-week, multicentre, double-blind, randomised, controlled trial (N=605). Eligible (≥12 years old) had persistent asthma...
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is a genetic with high phenotypic variability. Insights into ADPKD progression could lead to earlier detection and management prior end stage (ESKD). We sought identify patients rapid decline (RD) in function determine clinical factors associated RD using data-driven approach. Methods A retrospective cohort study was performed among incident (1/1/2002-12/31/2018). Latent class mixed models were used rapidly declining...