A5062456488- Spatial Cognition and Navigation
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Gaze Tracking and Assistive Technology
- Cognitive Abilities and Testing
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Geographic Information Systems Studies
- Birth, Development, and Health
- Human Health and Disease
- Magnetic and Electromagnetic Effects
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Historical Geography and Cartography
- Dietary Effects on Health
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Identity, Memory, and Therapy
- Evacuation and Crowd Dynamics
- Spaceflight effects on biology
Instituto Cajal
2022-2024
Consejo Superior de Investigaciones Científicas
2024
Abstract Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and associated toxicity have questioned clinical impact of this approach emphasized need alternative treatments. Given limited therapeutic options available these poor understanding molecular mechanisms underlying resistance metastatic lesions to WBRT, we sought uncover actionable targets biomarkers that could help refine patient...
Abstract Aging involves the deterioration of organismal function, leading to emergence multiple pathologies. Environmental stimuli, including lifestyle, can influence trajectory this process and may be used as tools in pursuit healthy aging. To evaluate role epigenetic mechanisms context, we have generated bulk tissue single cell multi-omic maps male mouse dorsal hippocampus young old animals exposed environmental stimulation form enriched environments. We present a molecular atlas aging...
Physical exercise is a robust lifestyle intervention known for its enhancement of cognitive abilities. Nevertheless, the extent to which these benefits can be transmitted across generations (intergenerational inheritance F1, and transgenerational F2 beyond) remains topic limited comprehension. We have already shown that improvements resulting from physical inherited parents their offspring, proving intergenerational effects. So, we set out explore whether enhancements might extend...
Abstract Lifestyle factors, particularly physical exercise, significantly influence brain structure and cognitive function through a hormetic effect dependent on exercise intensity duration. The underlying mechanisms of this profile remain largely unexplored. Recently, the gut microbiota, has emerged potent modulator lifestyle-induced changes behavior. Here, we demonstrate that 40-minute protocol moderate enhances abilities related to object recognition memory, increases hippocampal...
Summary Lifestyle induces long lasting effects on brain and cognition, with some interventions like stress including transgenerational inheritance mediated by epigenetic mechanisms. Physical exercise is one lifestyle intervention driving robust improvements of intergenerational transmission to the litter. However, little known about whether are transgenerationally transmitted. Here we analyzed adult hippocampal neurogenesis (AHN) behavioral phenotype sedentary male mice F2 generation...
Spatial navigation is a key aspect of human behavior and it still not completely understood. A number experimental approaches exist, although most the published data in last decades have relied on virtual maze on-screen simulation or not-completely freely moving 3D devices. Some interesting recent developments, such as circular mazes, contributed to analyze critical aspects spatial real space, dedicated protocols only allow for simple approaches. Here, we developed both specifically designed...