A5026362288- Gut microbiota and health
- Diet and metabolism studies
- Zebrafish Biomedical Research Applications
- Eating Disorders and Behaviors
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
- Insect Utilization and Effects
- Genetics, Bioinformatics, and Biomedical Research
- Cell Image Analysis Techniques
- Insect behavior and control techniques
- Genomics and Phylogenetic Studies
- Radiopharmaceutical Chemistry and Applications
- Mosquito-borne diseases and control
- Neurobiology and Insect Physiology Research
- Dietary Effects on Health
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Insect symbiosis and bacterial influences
- Nutritional Studies and Diet
- Microbial Metabolism and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Parasitic Diseases Research and Treatment
University College Cork
2023-2025
APC Microbiome Institute
2023-2025
Center for Climate and Resilience Research
2024
Pontificia Universidad Católica de Chile
2020-2023
University of Chile
2021
The integrated framework of in silico , vitro and vivo approaches identifies bacterial strains with the potential to degrade prebiotics, produce neuroactive molecules, alter stress-related gene expression behaviour a zebrafish model.
Abstract Objective: Compulsive-like rigidity may be associated with hyposerotonergia and increased kynurenine (KYN) pathway activity. Conversion of tryptophan (TRP) to (KYN), which contribute hyposerotonergia, is bolstered by inflammation, could related altered gut microbiota composition. Here, we studied these mechanisms in a naturalistic animal model compulsive-like behavioural rigidity, i.e., large nest building (LNB) deer mice ( Peromyscus sp.). Methods: Twenty-four (24) normal (NNB)- 24...
The composition and function of the human gut microbiome has been linked to multiple health outcomes across all world regions, often with region-specific associations. Unfortunately, extent which microbiomes from different populations are characterised is limited by their economic resources. Over 70% sequenced come analyses European North American populations, skewing our understanding focusing excessively on just 15% global population. Thus, entire continents rely results research conducted...
Because of its outstanding biological and industrial importance, many efforts have been made to characterize the mycobiota new environments their biochemical biotechnological potentials. Gut can be a source novel yeasts with potential used as probiotics or applications. In this work, we characterized two as-yet unexplored yeast communities from intestinal content cultured marine Chilean fishes Genypterus chilensis (G. chilensis) Seriolella violacea (S. violacea). Yeasts were isolated through...
The host microbiome plays an essential role in health and disease. Microbiome modification by pathogens or probiotics has been poorly explored especially the case of probiotic yeasts. Next-generation sequencing currently provides best tools for their characterization. Debaryomyces hansenii 97 ( D. 97) Yarrowia lipolytica 242 Y. 242) are yeasts that protect wildtype zebrafish Danio rerio ) larvae against a Vibrio anguillarum V. infection, increasing survival rate. We investigate effect these...
ABSTRACT Lactiplantibacillus plantarum is a commensal bacterial species often found within the human gut. To expand our knowledge about this human-associated taxon with potential probiotic properties, here we present draft genome sequence of strain APC2688, isolated from fecal sample.
Abstract Ageing is usually associated with physiological decline, increased mental health issues, and cognitive deterioration, alongside specific changes in the gut microbiome. However, relationship between neuroactive potential of microbiome cognition among elderly remains less explored. This study examines a cohort 153 older Chilean adults complaints, assessing anthropometric data, via five distinct tests, composition through 16SV4 sequencing. Our findings reveal associations factors...
Abstract Lifestyle factors, particularly physical exercise, significantly influence brain structure and cognitive function through a hormetic effect dependent on exercise intensity duration. The underlying mechanisms of this profile remain largely unexplored. Recently, the gut microbiota, has emerged potent modulator lifestyle-induced changes behavior. Here, we demonstrate that 40-minute protocol moderate enhances abilities related to object recognition memory, increases hippocampal...
Major Depressive Disorder (MDD) is a highly prevalent, severe mental health condition that constitutes one of the leading causes disability worldwide. While recent animal studies suggest causal role gut microbiome in pathophysiology MDD models, evidence humans still unclear due to small sample sizes, inconsistent clinical assessment diagnosis, and methodological limitations regarding inference cross-sectional data. Here, we explicitly address these shortcomings investigate potential link...