A5055919180- Pregnancy and preeclampsia studies
- Blood Coagulation and Thrombosis Mechanisms
- Preterm Birth and Chorioamnionitis
- Venous Thromboembolism Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Gut microbiota and health
- Urinary Tract Infections Management
- Cardiovascular Issues in Pregnancy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy-related medical research
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Infant Nutrition and Health
- Complement system in diseases
- Birth, Development, and Health
- Lung Cancer Diagnosis and Treatment
- Garlic and Onion Studies
- Neurological Complications and Syndromes
- Nitric Oxide and Endothelin Effects
- Urticaria and Related Conditions
- Probiotics and Fermented Foods
- Advanced Breast Cancer Therapies
- Pain Management and Opioid Use
Medical University of Graz
2012-2024
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2020
Graz University Hospital
2013
Copenhagen University Hospital
2012
University of Copenhagen
2012
Rigshospitalet
2012
Vienna General Hospital
2012
Medical University of Vienna
2012
University Hospital Innsbruck
2012
Odense University Hospital
2012
Abstract Objective Transvaginal sonography (TVS) is routinely performed as part of a pelvic sonogram in postmenopausal women, and images the endometrium are frequently obtained. In women without vaginal bleeding, threshold separating normal from abnormally thickened not known. The aim this study was to determine an endometrial thickness that should prompt biopsy woman bleeding. Methods This theoretical cohort aged 50 years older who were receiving hormone therapy. We determined risk cancer...
Summary Pregnancy is associated with substantial changes in the haemostatic system and a six-fold higher incidence of venous thromboembolism. Conventional global tests, such as prothrombin time activated partial thromboplastin time, do not definitely detect this hypercoagulable condition. We investigated whether during pregnancy are reflected calibrated automated thrombography (CAT). Thrombin generation was measured platelet-poor plasma (PPP) 150 healthy pregnant women without any diseases...
The microbial ecosystem of women undergoes enormous changes during pregnancy and the perinatal period. Little is known about extent in maternal microbiome beyond vaginal cavity its recovery after birth. In this study, we followed pregnant [maternal prepartum (mpre),
The objective was to investigate the association between chorionicity-specific intertwin birthweight discordance and adverse outcomes including long-term follow up at 6, 18, 48-60 months after term via Ages Stages Questionnaire.In this secondary analysis of a cohort study (Oldenburg et al., n = 1688) randomized controlled trial (PREDICT study, 1045) twin pairs were divided into three groups according discordance: <75th percentile, 75th-90th percentile >90th percentile. Information on infant...
In Brief OBJECTIVE: To estimate the association between cytokine levels in twin pregnancies and risk of spontaneous preterm delivery, including effect progesterone treatment. METHODS: This secondary analysis a randomized placebo-controlled trial investigating treatment on delivery included 523 women with available dried blood spot samples collected before (n=258) or placebo (n=265) after 4–8 weeks Samples were analyzed for cytokines using sandwich immunoassay. Cytokine at 34–37 gestation 34...
The causes for preterm birth (PTB) often remain elusive. We investigated whether circulating human milk oligosaccharides (HMOs) might be involved in modulating urinary and vaginal microbiome promoting or preventing PTB. identified here HMOs key microbial taxa associated with indicators of Based on our results, we propose two models how modulate risk PTB: (i) by changes sterile inflammation (microbiome-independent) (ii) HMO-driven shifts (microbiome-dependent). Our findings will guide current...
Progesterone treatment in second and third trimester of pregnancy has been shown to reduce the risk preterm delivery high-risk singleton gestations. This study was conducted investigate preventive effect vaginal progesterone a large population twin A double-blind, placebo-controlled randomised trial performed 17 centres Denmark Austria. Women with gestations were at 20–24 weeks' gestation daily pessaries or identically looking placebo until 34 gestation. Primary outcome spontaneous...
Background: The neonatal hemostatic system exhibits a fragile balance featuring lower levels of clotting factors as well inhibitors. Neonatal platelets show in-vitro hypoaggregability, but neonates exhibit well-functioning primary and secondary hemostasis despite this impairment. Recently, polyphosphate shed by activated has been shown to induce prothrombotic shift on the plasmatic coagulation adults. impact platelet derived might differ in due aforementioned peculiarities. Aims: We aimed...
Microangiopathic hemolytic anemias and thrombocytopenias in pregnant or postpartum women constitute an interdisciplinary diagnostic therapeutic challenge the evaluation of thrombotic microangiopathies (TMA), where urgent care must be considered. We here report case a 21-year-old Somali woman, who was delivered by emergency caesarean section at 35 weeks gestational age with acute dyspnea, placental abruption gross edema due to severe preeclampsia/HELLP syndrome. After delivery, she developed...
Preeclampsia still represents a life-threatening pregnancy complication, associated with severe maternal and neonatal morbidity mortality. Low-dose Aspirin is advised to avoid preeclampsia in high-risk pregnancies worldwide. As does not cover all women at risk, the prescription raises questions concerning optimal target population, dosage, onset of therapy. The aim this study was test platelet responsiveness on by optical aggegrometry, gain robust biochemically assessment data an obstetric...
Progesterone treatment reduces the risk of preterm delivery (PTD) in high-risk singleton gestations. Our aim was to evaluate preventive effect vaginal progesterone twin This is a sub study Danish-Austrian double-blind, placebo-controlled randomized trial (PREDICT study), where women with gestations were daily or placebo pessaries from 20–24 weeks until 34 weeks' gestation. population consists pregnancies defined as cervical length ⩽ 10th centile at current pregnancy history either...
Preeclampsia, with its reported incidence of about 5% pregnancies, is an important cause maternal and fetal morbidity mortality. Its exact pathogenesis remains uncertain, but many studies have demonstrated that preeclampsia a multisystemic syndrome characterized by (1–4) ● vasoconstriction, metabolic changes, endothelial cell dysfunction, activation the coagulation system, increased inflammatory response.
ABSTRACT Recent research provides new insights into the early establishment of infant gut microbiome, emphasizing influence breastfeeding on development gastrointestinal microbiomes. In our study, we longitudinally examined taxonomic and functional dynamics oral tract (GIT) microbiomes healthy infants ( n = 30) in their first year, focusing often-over-looked aspects, archaeal anaerobic Breastfed (BF) exhibit a more defined transitional phase microbiome compared to non-breastfed (NBF)...
Abstract Background Preterm birth is one of the leading causes neonatal mortality. The for spontaneous preterm (PTB) are multifactorial and remain often unknown. In this study, we tested hypothesis that human milk oligosaccharides (HMOs) in blood urine modulate maternal urinary vaginal microbiome influence risk PTB. We analyzed a cross-sectional cohort women with without labor correlated our findings measurements metabolites HMOs blood. Results identified several microbial signatures...
Delayed interval delivery in twin pregnancies is an unusual occurrence, even more so triplet pregnancies. We report on a delayed dichorionic triamniotic pregnancy after vitro fertilization (IVF). Because of severe to transfusion syndrome (TTTS), two fetuses demised at 22 weeks gestation. One the spontaneously aborted 25 The remaining live fetus and second were delivered by cesarean section 9 later because occurrence preeclampsia. This case indicates that triplets possible preeclampsia can...
Nitric oxide donors (NO-donors) have been shown to therapeutic potential (e.g., ischemia/reperfusion injury). However, due their release rate/antiplatelet properties, they may cause bleeding in patients. We therefore studied the antiplatelet effects of two different NO-donors, i.e., S-NO-Human Serum Albumin (S-NO-HSA) and Diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA-NONOate) whole blood (WB) samples. WB samples were spiked with S-NO-HSA or DEA-NONOate (100 µmol/L 200...
Abstract The microbial ecosystem of women undergoes enormous changes during pregnancy and the perinatal period. Little is known about extent in maternal microbiome beyond vaginal cavity its recovery after birth. In this study, we followed pregnant (mpre, n = 30) into postpartum period (1 month postpartum, mpost, 30). We profiled their oral, urinary, microbiome, archaeome, mycobiome urinary metabolome compared them with nonpregnant (np, 29). Overall, status mpre, mpost) had a smaller effect...