A5070281210- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Healthcare Policy and Management
- Viral Infections and Vectors
- Global Maternal and Child Health
- Retinoids in leukemia and cellular processes
- Nail Diseases and Treatments
- Healthcare Systems and Reforms
- Bacterial Infections and Vaccines
- Enzyme function and inhibition
- Global Health Care Issues
- Phosphodiesterase function and regulation
- Viral Infections and Outbreaks Research
- Pneumonia and Respiratory Infections
- Urticaria and Related Conditions
- Blood Pressure and Hypertension Studies
- Respiratory viral infections research
- Child and Adolescent Health
- Asthma and respiratory diseases
- Mosquito-borne diseases and control
- Nutritional Studies and Diet
- Skin Protection and Aging
- Sodium Intake and Health
- Retinopathy of Prematurity Studies
Health Action by People
2017-2025
Kerala University of Health Sciences
2020-2023
Government Medical College
2016-2021
Bausch Health (United States)
2014-2020
University of Kerala
2020
Dr. Somervell Memorial CSI Medical College and Hospital
2016-2017
Government Medical College and Hospital
2017
Medical University of South Carolina
2006
University of California, Los Angeles
1993
Versar (United States)
1962
Objective To evaluate the performance of non-laboratory INTERHEART risk score (NL-IHRS) to predict incident cardiovascular disease (CVD) across seven major geographic regions world. The secondary objective was fasting cholesterol-based IHRS (FC-IHRS). Methods Using measures discrimination and calibration, we tested NL-IHRS (n=100 475) FC-IHRS (n=107 863) for predicting CVD in a community-based, prospective study regions: South Asia, China, Southeast Middle East, Europe/North America, America...
Biologics are being used increasingly to treat moderate‐to‐severe psoriasis. Efficacy may differ in patients with previous exposure biologics. To investigate the impact of biologic on efficacy and safety brodalumab ustekinumab plaque Two placebo‐ ustekinumab‐controlled phase III clinical trials. There was an initial 12‐week induction where were treated [210 mg or 140 every 2 weeks (Q2W)], placebo. end points included ≥ 75% improvement Psoriasis Area Severity Index (PASI 75) static...
Brodalumab is efficacious for the treatment of moderate-to-severe plaque psoriasis through 52 weeks.To evaluate efficacy and safety brodalumab 120 weeks, including following withdrawal retreatment.At baseline, patients were randomized to (n = 222) or placebo 220). At week 12, achieving a static Physician's Global Assessment (sPGA) score 0 1 (sPGA 0/1) with rerandomized 83) 84; later re-treated if sPGA ≥ 3 occurred), receiving switched 208). Safety was assessed by exposure-adjusted rates...
Abstract Objective To evaluate the effectiveness of Hospital Disaster Management (HDM) Skill Training Program (STP), focusing on learning and behavior nurse educators. Methods The study design was a randomized control trial with pre-test post-test group blinding outcome assessor. sample includes educators in selected collegiate nursing institutions, 30 participants experimental groups. training delivered hybrid mode, were randomly assigned to validated using Delphi technique. Learning...
Saccharomyces cerevisiae strain PP5 has a phosphodiesterase (PDE) deficiency that results in heat-shock sensitivity due to the intracellular accumulation of cAMP. This also carries cam mutation, which confers permeability cAMP and, as shown here, other compounds. Expression rat type IV PDE these cells caused them revert resistance. Treatment transformed with rolipram, an antidepressant humans and potent inhibitor PDEs, reinstated heat shock. The biochemical properties deletion mutants this...
Oat beta‐glucan is a water soluble, linear polymer of glucose consisting 1,4 (70%) and 1,3 (30%) linkages with an average molecular weight 1 × 10 6 Da. Scientific reports indicate film‐forming moisturizer, biological response modifier, promoter wound healing. Our objective was to study the penetration oat (1,4:1,3) in human skin models evaluate clinically its efficacy for reducing fine‐lines wrinkles. Penetration studies performed on abdominal used single application 0.5% solution at dose 5...
Patients with psoriasis have lesional symptoms, including itch, which can reduce quality of life. The efficacy and safety brodalumab, an interleukin-17 receptor A antagonist, in treating moderate-to-severe been reported three randomized, controlled, phase 3 trials (AMAGINE-1/-2/-3).The effect brodalumab on symptoms was assessed using the symptom inventory (PSI), a validated patient-reported instrument.Patients were randomized to receive (140 or 210 mg every 2 weeks [Q2W]), placebo...
Background Brodalumab, a fully human anti-interleukin-17 receptor A monoclonal antibody, has demonstrated superior efficacy and safety over ustekinumab as induction therapy for moderate-to-severe psoriasis. Objectives To evaluate the of brodalumab through week 52 in patients who had inadequate responses to ustekinumab. Methods subgroup analysis phase III AMAGINE-2/-3 double-blind randomized controlled trials was performed. Participants were aged 18–75 years Psoriasis Area Severity Index...
Social capital, characterised by trust, reciprocity and cooperation, is positively associated with a number of health outcomes. We test the hypothesis that among hypertensive individuals, those greater social capital are more likely to have their hypertension detected, treated controlled.Cross-sectional data from 21 countries in Prospective Urban Rural Epidemiology study were collected covering 61 229 individuals aged 35-70 years, households 656 communities which they live. Outcomes include...
We have created a series of deletion mutants human cardiac cAMP phosphodiesterase in order to define sequences necessary for function and identify residues required inhibition by cGMP the drugs milrinone trequinsin. These truncated constructs were expressed yeast cells, their biochemical properties analyzed. The mutations an amino acid sequence that is essential function. Among active constructs, there was considerable variability level expression stability proteins, with full-length near...
Efinaconazole is a new triazole antifungal for topical treatment of onychomycosis. The reproductive and developmental toxicity efinaconazole was characterized in fertility early embryonic development (rat), embryo-fetal (rat rabbit), peri/post-natal (rat) studies accordance with current ICH guidances. In the study, maternal noted as estrous cycle prolongation (NOAEL = 5 mg/kg/day) but there were no male effects even presence paternal 25 mg/kg/day). Rat perinatal pup lethality most sensitive...
Background: Early detection of curable cancers is a cost-effective way to address the cancer care burden low- and middle-income countries active engagement primary physicians using mobile technology can have significant impact on outcomes in short time. Aims: To describe process mHealth study; Oncology Education Training for Providers Mobile Phones which developed application (M-OncoEd) educate approaches early cancers. It also aims how insight gained through qualitative research by...
BackgroundScrub typhus is a potentially fatal rickettsial infection endemic in Asia. But there are only very few reports of pediatric scrub from Southern Kerala, which situated South India.ObjectiveTo study the clinicoepidemiological profile patients with Kerala.MethodsClinical 108 consecutive, 1- to 12-year-old children diagnosed admitted tertiary care teaching hospital India August 2011 May 2015 was studied.ResultsThe median age affected 6.83 years male female ratio 1.42:1. Definite...
Staphylococcus aureus has largely developed resistance to the multiple antimicrobial agents. Garlic (Allium sativum) is claimed retard development of and produce synergy with conventional The aim present study was evaluate effect combination ampicillin fresh garlic extract (FGE) against S. by using in vitro method.Antimicrobial activity FGE studied well diffusion broth dilution methods. checkerboard method clinical isolates aureus. organisms were exposed individual as different combinations...
The concept of research for the postgraduates, its scope and debating points in Indian context are described discussed this article. as part postgraduate activity is along with importance methodology, followed by barriers faced doing good research. After introductory part, debate identified listed initiation discussion. alternate viewpoints also each discussion point. suggestions put forth initiating further debate.
ObjectiveThe objective of this study is to evaluate the risk factors in very low birth weight preterm newborns screened for retinopathy prematurity (ROP) a tertiary care hospital and find relationship severity disease. Very few reports on ROP are available from part South India.MethodsA prospective screening was done enrolling 812 babies during period April 2013 2015 followed up until maturation retina or regression The population included preterms ≤32 weeks ≤1500 g at admitted newborn...
A hospital-based sentinel surveillance network for bacterial meningitis was established in India to estimate the burden of meningitis, and proportion major vaccine-preventable causative organisms. This report summarises findings conducted between March 2012, September 2016 eleven hospitals.We enrolled eligible children with age group one 59 months. CSF samples were collected processed biochemistry, culture, latex agglutination, real-time PCR. Pneumococcal isolates serotyped tested...