A5074712286- Neuroscience and Music Perception
- Neural dynamics and brain function
- Multisensory perception and integration
- Neurobiology of Language and Bilingualism
- Hearing Loss and Rehabilitation
- EEG and Brain-Computer Interfaces
- Noise Effects and Management
- Phonetics and Phonology Research
- Functional Brain Connectivity Studies
- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Action Observation and Synchronization
- Reading and Literacy Development
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Face Recognition and Perception
- Speech and Audio Processing
- Aesthetic Perception and Analysis
- Reproductive Biology and Fertility
- Image Processing Techniques and Applications
- bioluminescence and chemiluminescence research
- Hepatitis B Virus Studies
- Image and Video Stabilization
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer, Stress, Anesthesia, and Immune Response
Beijing Language and Culture University
2021-2025
Peking University
2012-2021
Chinese Institute for Brain Research
2014-2021
McGovern Institute for Brain Research
2019
Center for Life Sciences
2017
Nanjing Medical University
2014
Jiangsu Province Hospital
2014
Cleveland Clinic
2008
University of Pennsylvania
1995
Abstract The perception of speech tempo is influenced by both the acoustic properties and cognitive state listener. However, there a lack research on how comprehension affects tempo. This study aims to disentangle impact manipulating linguistic structures measuring perceptual at explicit implicit levels. Three experiments were conducted explore these relationships. In Experiment 1, two tasks revealed that listeners tend overestimate sentences with low comprehensibility, although this effect...
Speech mental imagery is a quasi-perceptual experience that occurs in the absence of real speech stimulation. How imagined with higher-order structures such as words, phrases and sentences rapidly organized internally constructed remains elusive. To address this issue, subjects were tasked imagining perceiving poems along sequence reference sounds presentation rate 4 Hz while magnetoencephalography (MEG) recording was conducted. Giving sentence traditional Chinese poem five syllables,...
The excitotoxic response of NT2-N cells, a clonal line human teratocarcinoma cells that are terminally differentiated into neuron-like was examined using several endpoints. A 15 min exposure to glutamate produced dose-dependent toxicity with maximal cell loss 80-90% in 6 week old cells. rapidly triggered excitotoxicity induced by blocked NMDA selective antagonists, calcium dependent and pH sensitive could be mimicked but not non-NMDA agonists, AMPA, kainate or quisqualate. agonists however...
Native speakers excel at parsing continuous speech into smaller elements and entraining their neural activities to the linguistic hierarchy different levels (e.g., syllables, phrases, sentences) achieve comprehension. However, how a nonnative brain tracks hierarchical structures in second language (L2) comprehension whether it relates top-down attention proficiency remains elusive. Here, we applied frequency-tagging paradigm human adults investigated tracking responses hierarchically...
The subjective inner experience of mental imagery is among the most ubiquitous human experiences in daily life. Elucidating neural implementation underpinning dynamic construction critical to understanding high-order cognitive function brain. Here, we applied a frequency-tagging method isolate top-down process speech from bottom-up sensory-driven activities and concurrently tracked processing time scales corresponding two processes subjects. Notably, by estimating source...
The subjective representation of the sounds delivered to two ears a human listener is closely associated with interaural delay and correlation these two-ear sounds. When sounds, e.g., arbitrary noises, arrive simultaneously, single auditory image binaurally identical noises becomes increasingly diffuse, eventually separates into images as decreases. increases from zero several milliseconds, also changes distinct images. However, measuring effect factors on an group participants has not been...
This study investigated whether sound intensity affects listeners’ sensitivity to a break in interaural correlation (BIC) embedded wideband noise at different delays. The results show that the detection duration threshold remained stable between 60 and 70 dB SPL, but increased accelerating fashion as decreased toward 40 SPL. Moreover, elevated linearly delay from 0 4 ms, elevation slope became larger 50 Thus, detecting BIC is co-modulated by both delay.
Abstract Objective. Magnetoencephalography (MEG) is a powerful non-invasive diagnostic modality for presurgical epilepsy evaluation. However, the clinical utility of MEG mapping localising epileptic foci limited by its low efficiency, high labour requirements, and considerable interoperator variability. To address these obstacles, we proposed novel artificial intelligence–based automated magnetic source imaging (AMSI) pipeline detection localisation sources from data. Approach. expedite...
NT2 cells are a clonal line of human teratocarcinoma that exhibit N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity after terminal differentiation into NT2-N neurons. In this study, we used modulation glutamate to characterize the pharmacological properties and specific antibodies determine individual subunits NMDA receptors expressed by The glycine site antagonist 7-chlorokynurenic acid completely blocked toxicity in dose-dependent manner. Histamine polyamine agonists spermine...
Abstract Humans excel at constructing mental representations of speech streams in the absence external auditory input: internal experience imagery. Elucidating neural processes underlying imagery is critical to understanding this higher-order brain function humans. Here, using functional magnetic resonance imaging, we investigated shared and distinct correlates imagined perceived by asking participants listen poems articulated a male voice (perception condition) imagine hearing spoken that...
Spatial hearing in humans is a high-level auditory process that crucial to rapid sound localization the environment. Both neurophysiological models with animals and neuroimaging evidence from human subjects wakefulness stage suggest of objects mainly located posterior cortex. However, whether this cognitive preserved during sleep remains unclear. To fill research gap, we investigated sleeping brain's capacity identify locations by recording simultaneous electroencephalographic (EEG)...
Purpose: In the context of a cocktail party listening environment, processing different linguistic hierarchy levels in unattended speech and their influence on target recognition remain controversial. This study aims to investigate how structures (such as syllable, word, sentence) competing speech-to-speech masking situation. Method: Thirty-six participants were instructed recognize when it was masked by varied types across syllables, words, sentence. The perceived spatial location altered...
Speech comprehension requires listeners to rapidly parse continuous speech into hierarchically-organized linguistic structures (i.e. syllable, word, phrase, and sentence) entrain the neural activities rhythm of different levels. Aging is accompanied by changes in processing, but it remains unclear how aging affects levels representation. Here, we recorded magnetoencephalography signals older younger groups when subjects actively passively listened which hierarchical sentence were tagged at...
The adult brain can efficiently track both lower-level (i.e., syllable) and higher-level phrase) linguistic structures to comprehend speech. When children actively or passively listened speech, we found robust neural tracking of syllabic structure but marginally significant phrasal structure.
Under a “cocktail party” environment, listeners can utilize prior knowledge of the content and voice target speech [i.e., auditory priming (ASP)] perceived spatial separation to improve recognition among masking speech. Previous studies suggest that these two unmasking cues are not processed independently. However, it is unclear whether effects supported by common neural bases. In current study, we aimed first confirm ASP contribute improvement interactively in multitalker condition further...
The pitch processing of language and music is generally considered engaging overlapped neural correlates. Previous studies on musicians showed that the ability in could be transferred to language. It known training can facilitate speech, however, underlying mechanisms are not fully understood, especially non-musicians. Using magnetoencephalography, we presented a anomaly paradigm which consists language/music phrases ending either congruous or incongruous tones/pitches We found distinctive...
Background:Organ pool was expanded after introduction of liver graft from donors cardiac death. But owing to the inevitable warm-ischemia before procurement, these livers showed higher incidence severe complications, e.g. primary nonfunction. Widespread utilization DCD requires novel preservation strategy. Methods:Liver transplantation (LTx) using Sprague-Dawley rats (250g, male) employed access potential methods. All rat were randomized into following groups according procurement and...