A5092082139- Lipid metabolism and disorders
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Artificial Immune Systems Applications
Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
First Affiliated Hospital of Guangzhou Medical University
2024
Nanjing Medical University
2023
Abstract Secreted phospholipase A2s are involved in the development of obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease, which have become serious growing health concerns worldwide. Integration genome‐wide association study gene co‐expression networks analysis showed that secreted A2 group XIIA (PLA2G12A) may participate hepatic lipids metabolism. Nevertheless, role PLA2G12A lipid metabolism its potential mechanism remain elusive. Here, we used AAV9 vector carrying human...
Mucosal immunity is crucial for preventing the infection and transmission of respiratory viruses. Nasal antibody inversely correlated with a lower risk However, current reference standard nasal assessment serum-based, mainly consisting monomeric IgG IgA. The applicability serum-derived standards assessing antibodies, mostly dimeric or polymeric secretory IgA (sIgA), remains unvalidated. Herein, we first proved that sera-derived was not applicable antibodies. Using non-homologous as...
Introduction Infection with SARS-CoV-2 begins in the upper respiratory tract and can trigger production of mucosal spike-specific secretory IgA (sIgA), which provides protection against reinfection. It has been recognized that individuals high level nasal have a lower risk However, sIgA wanes over time, different may various descending kinetics, leading to individual differences susceptibility A method for detecting passage would be valuable predicting reinfection so people at better...
Nonalcoholic fatty liver disease (NAFLD) is considered a major health epidemic with an estimated 32.4% worldwide prevalence. No drugs have yet been approved and therapeutic nodes remain unmet need. Long noncoding RNAs are emerging as important class of novel regulators influencing multiple biological processes the pathogenesis NAFLD. Herein, we described long RNA, lnc_217, which was enriched upregulated in high-fat diet-fed mice, genetic animal model We found that specific knockdown lnc_217...