A5009704063- Vasculitis and related conditions
- Systemic Sclerosis and Related Diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders Research
- Blood disorders and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Atherosclerosis and Cardiovascular Diseases
- Chronic Lymphocytic Leukemia Research
- Connective Tissue Growth Factor Research
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Methemoglobinemia and Tumor Lysis Syndrome
- Galectins and Cancer Biology
- Immune responses and vaccinations
- Pericarditis and Cardiac Tamponade
- Gastrointestinal disorders and treatments
- Marine Toxins and Detection Methods
- Orthopedic Infections and Treatments
- Tracheal and airway disorders
- Inflammasome and immune disorders
- Vascular Anomalies and Treatments
Government Medical College
2021-2025
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2019-2024
Post University
2020
Government Medical College
2017
Government Medical College
2017
Abstract Background and Objective: Interstitial lung diseases (ILD) are a heterogeneous group of resulting in inflammation fibrosis parenchyma they on rising trend nowadays. An ILD registry offers an opportunity to understand disease patterns, standardize care, provide relevant longitudinal data. There is unmet need for studies the epidemiology ILDs from South India. This study aims find out clinical spectrum tertiary care center Materials Methods: observational epidemiological conducted 1...
Ciguatoxin (CTX) is a visibly unidentifiable, colourless, odourless, heat stable and lipid soluble polyether marine biotoxin associated with human illness. Marine dinoflagellates under the genus Gambierdiscus are responsible for producingciguatoxins (CTX). The ciguatoxin gets accumulated in herbivorous fishes, biotransformed carnivorous fishes finally reach fish consumers. In January 2016, individuals who consumed red snapper Trivandrum, Kerala, India weresuspected to be intoxicated...
Abstract Introduction The adenosine pathway is one of the ways through which methotrexate (MTX) ameliorates inflammation. We therefore explored an association polymorphism genes involved in and MTX metabolic pathways with response to MTX. Methods Association 7 (rs2236225 [ MTHFD1 1958G>A], rs17602729 AMPD1 G>A], rs1127354 ITPA C>A], rs1431131 TGFBR2 A>T], rs2372536 ATIC C>G], rs11188513 ENTPD1 C>T] rs5751876 ADORA2A T>C]) efficacy was studied Indian rheumatoid arthritis...
Background: While patients with systemic sclerosis (SSc) are predisposed to cardiovascular events, data regarding this from India is sparse. We analysed correlates of subclinical atherosclerosis in Indian SSc. Methods: Patients SSc fulfilling the 2013 classification criteria ( n = 61) were recruited after obtaining written informed consent. Clinical risk factors for disease (CVD) assessed. A carotid ultrasound was performed assess mean intima-media thickness (CIMT). Total and endothelial...
<h3>Background:</h3> With the advances in treatment of Rheumatoid arthritis, incidence vasculitis (RV) has decreased, especially Caucasian population. (1) There is a paucity studies on from Indian subcontinent and hence exact prevalence associations this population not clear. <h3>Objectives:</h3> We aimed to study prevalence, clinical characteristics, vasculitis. <h3>Methods:</h3> conducted retrospective records review all adult patients who fulfilled 2010 ACR EULAR classification criteria...
<title>Abstract</title> Common Variable Immunodeficiency (CVID) is a heterogeneous disorder characterized by impaired antibody production and recurrent infections. In this study we investigated the clinical immunological features of CVID in Indian patients develops machine learning model for predicting disease severity. We retrospectively analyzed 150 diagnosed with over decade at tertiary care center India. The median age diagnosis was 18 years, male predominance (62%). majority (66.6%) had...
To describe the clinical profile and treatment outcomes of a longitudinal series patients with rapidly progressive interstitial lung disease (RP-ILD) associated anti MDA 5 antibody. RP-ILD were identified from prospective cohort adult idiopathic inflammatory myopathy (IIM). Clinical, demographic, serological parameters all recorded using structured proforma. Rapidly ILD was defined as development radiological deterioration hypoxemia within 3 months onset respiratory symptoms. The diagnosis...
Abstract A 57‐year old gentleman had presented a year back with inflammatory oligoarthritis and vasculitic neuropathy, diagnosed as unclassifiable vasculitis, initiated on oral corticosteroids intravenous cyclophosphamide (monthly X 6). His disease stabilized he been maintained azathioprine, which to be stopped due acute pancreatitis subsequent pseudocyst formation, requiring percutaneous drainage suspecting infection. Within week of drainage, developed sudden onset pain in left upper limb,...
Abstract Background Despite methotrexate (MTX) being the first line therapy for RA,30% of patients do not respond to MTX. Methotrexate acts by increasing adenosine levels which lead anti-inflammatory effects. Adenosine deaminase (ADA) enzyme converts inosine thus reduces adenosine. Thus, ADA and single nucleotide polymorphism (SNP) in gene may affect treatment effect Our objective was study if genetic baseline serum with RA is associated response. Methods 207 DMARD naïve active (DAS28 ESR...
Histoplasmosis is an endemic mycosis caused by Histoplasma Capsulatum, a thermally dimorphic fungus with mycelial and yeast forms. Muscle involvement infrequent in Histoplasmosis.A 49-year-old lady presented generalized myalgia arthritis of two-year duration, which had responded partly to glucocorticoids. The reported us two years into the illness ulcerative eyelid lesions, worsening myalgia, painful skin nodules. Eventually, it turned out that anti-synthetase syndrome was primary diagnosis...
Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis (RA), but nearly 30% of RA patients do not respond to it. acts by enhancing level adenosine, which gets converted inosine enzyme adenosine deaminase (ADA). We studied whether ADA gene polymorphism and serum levels total are associated with responsiveness MTX.Two hundred seven disease-modifying antirheumatic drug-naive active (DAS28-ESR [Disease Activity Score-28 erythrocyte sedimentation rate] ≥3.2) satisfying European...
<h3>Background</h3> Idiopathic inflammatory myopathies (IIM) is a rare heterogenous group of diseases with varying involvement muscle, skin, joints and lung. There paucity prospective cohort studies in IIMs from India which assess the treatment response clinico serological profile patients IIM. <h3>Objectives</h3> To describe clinical characteristics, autoantibody early IIM attending Rheumatology clinic tertiary care teaching hospital South between October 2020 June 2022. compare...
<h3>Background</h3> Extra-articular manifestations are seen in around 40% of patients with Rheumatoid arthritis (RA) western studies and increase the mortality RA [1]. There is a paucity data from India, especially South India on prevalence associations extra-articular RA. <h3>Objectives</h3> To estimate frequency (EAM) their disease characteristics attending Rheumatology clinic tertiary care teaching hospital India. <h3>Methods</h3> A cross-sectional study 316 consecutive fulfilling 2010...
Use of reverse pull headgear (RPHG) is well advocated and widely used all over for the early correction developing Class III malocclusions, mainly in late mixed dentition period. Seldom are any articles found, on use RPHG postpubertal girls with facial profiles anterior open bite. Twinning teeth usually results from abnormalities development tooth. Clinically, such a tooth hampers esthetics available arch length, which necessitates multidisciplinary intervention. This article reports...