A5052473428- Heat shock proteins research
- Computational Drug Discovery Methods
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Heart rate and cardiovascular health
- thermodynamics and calorimetric analyses
- Takotsubo Cardiomyopathy and Associated Phenomena
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Lipid Membrane Structure and Behavior
- Cardiac, Anesthesia and Surgical Outcomes
- Endoplasmic Reticulum Stress and Disease
- Cardiac Arrhythmias and Treatments
- Spaceflight effects on biology
- Microbial Natural Products and Biosynthesis
- Cardiac pacing and defibrillation studies
- HER2/EGFR in Cancer Research
- Exercise and Physiological Responses
- Atrial Fibrillation Management and Outcomes
- Cancer Treatment and Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Infective Endocarditis Diagnosis and Management
- Lung Cancer Treatments and Mutations
University of Calgary
2013-2024
Chinese University of Hong Kong
2024
University of Hong Kong
2024
Libin Cardiovascular Institute of Alberta
2016-2023
University of British Columbia
2022
Alberta Health Services
2020
University of California, San Diego
2019
Calgary Laboratory Services
2014-2018
University of Ottawa
2012-2014
University of North Carolina at Chapel Hill
2010-2013
N-Linked biantennary, triantennary, and core fucosylated biantennary oligosaccharides were isolated from animal glycoproteins derivatized at their reducing end with Boc-tyrosine. The terminal Gal residues enzymatically removed replaced GalNAc. Tyrosinamide-oligosaccharides radioiodinated administered intravenously to mice. Pharmacokinetic biodistribution studies revealed structure-dependent differences in the steady-state volume of distribution, total body clearance rate, targeting...
Blood levels of heat shock protein (HSP27) and natural IgG auto-antibodies to HSP27 (AAbs) are higher in healthy controls compared cardiovascular disease patients. Vaccination mice with recombinant HSP25 (rHSP25, murine ortholog human rHSP27) increased AAb levels, attenuated atherogenesis reduced plaque inflammation cholesterol content. We sought determine if the immune complex (IC) altered MΦ signaling (Toll Like Receptor 4; TLR4), scavenger receptors involved uptake (SR-AI, CD-36)....
Inorganic mercury and cadmium are becoming increasingly prevalent due to industrial activity have been linked cardiovascular disease diabetes. The binding affinity of Hg, Cd, their mixtures biomimetic erythrocyte membranes was investigated by isothermal titration calorimetry in physiologically relevant media (100 mM NaCl, pH 7.4, 37 °C). thermodynamic parameters were not expressed per mole lipid but as metals liposomes. To our knowledge, this method is novel provides a more intuitive...
The Drug Design Data Resource (D3R) aims to identify best practice methods for computer aided drug design through blinded ligand pose prediction and affinity challenges. Herein, we report on the results of Grand Challenge 4 (GC4). GC4 focused proteins beta secretase 1 Cathepsin S, was run in an analogous manner prior In Stage 1, participant ability predict BACE1 ligands were assessed. Following completion all co-crystal structures released, 2 tested rankings with structures. We provide...
Abstract Aims Ivabradine is a selective sinus node inhibitor indicated in patients with symptomatic chronic heart failure on stable guideline‐recommended therapy including appropriate doses of beta‐blockers. The use cardiogenic shock remains off label and has been considered contraindication due to the theoretical risk attenuating compensatory tachycardia. Tachycardia, especially context inotropic therapy, may be deleterious, resulting increased myocardial oxygen consumption reduction...
Acetaminophen overdose is one of the most common causes acute hepatic failure in developed world. There strong evidence for N-acetylcysteine (NAC) as a safe and effective antidote acetaminophen toxicity. However, there less clarity management massive overdoses (acute, single <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"><a:mtext>ingestions</a:mtext><a:mo>></a:mo><a:mn>500</a:mn></a:math> mg/kg with 4-hour equivalent concentrations ~6000 μmol/L) which are often associated...
Blunt thoracic aortic injury (BTAI) is associated with high mortality and morbidity. Thoracic endovascular repair has become the recommended treatment modality given improved short-term results compared to open repair. We present a case of 19-year-old male who presented acute paralysis multiorgan dysfunction from TEVAR thrombosis. Systemic thrombolysis, catheter-directed thrombolysis followed by aspiration thrombectomy, angioplasty were initially successful in restoring perfusion. However,...
The Drug Design Data Resource aims to test and advance the state of art in protein-ligand modeling, by holding community-wide blinded, prediction challenges. Here, we report on our third major round, Grand Challenge 3 (GC3). Held 2017-2018, GC3 centered protein Cathepsin S kinases VEGFR2, JAK2, p38-α, TIE2, ABL1; included both pose- affinity-ranking components. was structured much like prior challenges GC2015 GC2. First, Stage 1 tested pose affinity ranking methods; then all available...
Objective Higher β-blocker dose and lower heart rate are associated with decreased mortality in patients systolic failure (HF) sinus rhythm. However, the 30% of HF atrial fibrillation (AF), whether or predict is less clear. We assessed association between dose, all-cause AF. Methods performed a retrospective cohort study 935 (60% men, mean age 74, 44.7% reduced left ventricular ejection fraction (LVEF)) discharged concurrent diagnoses used Cox models to test independent associations higher...
Glycopyrronium bromide has recently been approved as a once daily maintenance inhalation therapy for moderate to severe chronic obstructive pulmonary disease (COPD). Efficacy and safety trial data have found rare cases of significant QT prolongation. To our knowledge, we describe the first case report prolongation >600 ms with initiation glycopyrronium in real world setting. A 78-year-old female COPD started on bromide, presented Emergency Department (ED) syncope. Her past medical history...
Idiopathic giant cell myocarditis (GCM) has a fulminant course and typically presents in middle-aged adults with acute heart failure or ventricular arrhythmia. It is rare disorder which involves T lymphocyte-mediated myocardial inflammation. Diagnosis challenging requires high index of suspicion since therapy may improve an otherwise uniformly fatal prognosis.A previously healthy 54-year-old female presented hemodynamically significant arrhythmia (VA) was found to have severe left...
Abstract Blood levels of heat shock protein (HSP27) and natural IgG auto-antibodies to HSP27 (AAbs) are higher in healthy controls compared cardiovascular disease patients. Vaccination mice with recombinant HSP25 (rHSP25, murine ortholog human rHSP27) increased AAb levels, attenuated atherogenesis reduced plaque inflammation cholesterol content. We sought determine if the immune complex (IC) altered MΦ signaling (Toll Like Receptor 4; TLR4), scavenger receptors involved uptake (SR-AI,...
<div>The Drug Design Data Resource (D3R) aims to identify best practice methods for computer aided drug design through blinded ligand pose prediction and affinity challenges. Herein, we report on the results of Grand Challenge 4 (GC4). GC4 focused proteins beta secretase 1 Cathepsin S, was run in an analogous manner prior In Stage 1, participant ability predict BACE1 ligands were assessed. Following completion all co-crystal structures released, 2 tested rankings with structures. We...
Abstract BACKGROUND Glioblastoma (GB), the most aggressive form of brain tumor, presents a significant clinical challenge with devastating prognosis. Globally, median overall survival (OS) for GB is typically 12-15 months, largely due to its inherent resistance chemotherapy and radiotherapy. However, some patients exhibit prolonged survival, their specific demographic genomic characteristics remain poorly defined. Understanding profile these exceptional responders holds great promise...