A5056227215- Mesenchymal stem cell research
- Lysosomal Storage Disorders Research
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Biomedical Research and Pathophysiology
- Pluripotent Stem Cells Research
- Bone Metabolism and Diseases
- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- HER2/EGFR in Cancer Research
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Anesthesia and Neurotoxicity Research
- Blood disorders and treatments
- Vascular Malformations and Hemangiomas
- Histiocytic Disorders and Treatments
- Vascular Tumors and Angiosarcomas
- Trace Elements in Health
- Neurogenetic and Muscular Disorders Research
- Biomedical Ethics and Regulation
- Autoimmune and Inflammatory Disorders Research
- Genetic factors in colorectal cancer
- Oral health in cancer treatment
- Peptidase Inhibition and Analysis
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2024
The San Raffaele Telethon Institute for Gene Therapy
2019-2024
University of Milano-Bicocca
2016-2020
Dulbecco Telethon Institute
2017
// Gabriele Romano 1 , Ludovica Santi Maria Rosaria Bianco 2 Rita Giuffrè Mariateresa Pettinato Cristina Bugarin 3 Garanzini Leonilde Savarese 4 Silvia Leoni Grazia Cerrito Biagio Eugenio Leone Giuseppe Gaipa Emanuela Grassilli Michele Papa Marialuisa Lavitrano Roberto Giovannoni Department of Surgery and Translational Medicine, University Milano-Bicocca, 20900, Monza, Italy c/o Mental Physical Health Preventive Second Naples, 80138, M. Tettamanti Research Center, Pediatric Clinic, Milano...
Mucopolysaccharidosis type I Hurler (MPSIH) is characterized by severe and progressive skeletal dysplasia that not fully addressed allogeneic hematopoietic stem cell transplantation (HSCT). Autologous progenitor cell–gene therapy (HSPC-GT) provides superior metabolic correction in patients with MPSIH compared HSCT; however, its ability to affect manifestations unknown. Eight (mean age at treatment: 1.9 years) received lentiviral-based HSPC-GT a phase 1/2 clinical trial (NCT03488394)....
Necrotizing enterocolitis (NEC) is a devastating gut disease in preterm neonates. In NEC animal models, mesenchymal stromal cells (MSCs) administration has reduced the incidence and severity of NEC. We developed characterized novel mouse model to evaluate effect human bone marrow-derived MSCs (hBM-MSCs) tissue regeneration epithelial repair. was induced C57BL/6 pups at postnatal days (PND) 3–6 by (A) gavage feeding term infant formula, (B) hypoxia/hypothermia, (C) lipopolysaccharide....
Abstract Umbilical cord blood (UCB) is a promising source of stem cells to use in early haematopoietic cell transplantation (HSCT) approaches for several genetic diseases that can be diagnosed at birth. Mucopolysaccharidosis type I (MPS-I) progressive multi-system disorder caused by deficiency lysosomal enzyme α-L-iduronidase, and patients treated with allogeneic HSCT the onset have improved outcome, suggesting administer such therapy as possible. Given best characterized MPS-I murine model...
Mesenchymal stromal cells (MSCs) have been employed in vitro to support hematopoietic stem and progenitor cell (HSPC) expansion vivo promote HSPC engraftment. Based on these studies, we developed an MSC-based co-culture system optimize the transplantation outcome of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene-edited (GE) human HSPCs. We show that bone marrow (BM)-MSCs produce several supportive anti-inflammatory factors capable alleviating proliferation...
Bone marrow-mesenchymal stromal cells (BM-MSCs) are key components of the BM niche, where they regulate hematopoietic stem progenitor cell (HSPC) homeostasis by direct contact and secreting soluble factors. BM-MSCs also protect niche from excessive inflammation releasing anti-inflammatory factors modulating immune activity. Thanks to these properties, were successfully employed in pre-clinical HSPC transplantation models, increasing rate engraftment, accelerating hematological...
Introduction Autosomal recessive osteopetrosis (ARO) is a rare genetic disease, characterized by increased bone density due to defective osteoclast function. Most of the cases are TCIRG1 gene mutation, leading severe phenotype and death in first years life. The standard therapy hematopoietic stem cell transplantation (HSCT), but its success limited several constraints. Conversely, (GT) could minimize immune-mediated complications allogeneic HSCT offer prompt treatment these patients. Methods...