A5000410331- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Lipid metabolism and biosynthesis
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Diet and metabolism studies
- Protein Kinase Regulation and GTPase Signaling
- Amino Acid Enzymes and Metabolism
- Cancer-related Molecular Pathways
- Ion Transport and Channel Regulation
- Thyroid Disorders and Treatments
- Digestive system and related health
- Fatty Acid Research and Health
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Economic Policies and Impacts
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Labor market dynamics and wage inequality
- Experimental Behavioral Economics Studies
- Intergenerational and Educational Inequality Studies
- Second Language Learning and Teaching
ANT Foundation Italy Onlus
2023
Maastricht School of Management
2023
Maastricht University
2023
University of Leicester
2021
Marche Polytechnic University
2020
University of Milano-Bicocca
2016-2018
Azienda Socio Sanitaria Territoriale Lariana
2018
Sapienza University of Rome
2003-2012
Hôpital Pellegrin
2009
University of Florence
1998
Stimulation of resident peritoneal macrophages with S-[2,3-bis(pamitoyloxy)-(2R,2S)-propyl]-N-palmytoyl-(R)-C ysSerLys4 or S(-)[2,3-bis(pamitoyloxy)-(2R,2S)-propyl]-N-palmytoyl-(R)-++ +CysAlaLys4, two synthetic bacterial lipopeptides, promoted the expression inducible form nitric oxide synthase, exhibiting a temporal pattern release that was delayed respect to induction elicited by lipopolysaccharide. Treatment genistein blocked synthesis triggered lipopeptides Simultaneous incubation...
// Gabriele Romano 1 , Ludovica Santi Maria Rosaria Bianco 2 Rita Giuffrè Mariateresa Pettinato Cristina Bugarin 3 Garanzini Leonilde Savarese 4 Silvia Leoni Grazia Cerrito Biagio Eugenio Leone Giuseppe Gaipa Emanuela Grassilli Michele Papa Marialuisa Lavitrano Roberto Giovannoni Department of Surgery and Translational Medicine, University Milano-Bicocca, 20900, Monza, Italy c/o Mental Physical Health Preventive Second Naples, 80138, M. Tettamanti Research Center, Pediatric Clinic, Milano...
Summary objective To determine the incidence of antimicrobial‐resistant, nonpathogenic Escherichia coli among healthy children aged 6–72 months in Camiri town and a rural village, Javillo, south‐eastern Bolivia. method A community‐based survey: stool samples were obtained from 296 selected by modified cluster sampling all 25 eligible Javillo. E. isolates tested for antimicrobial susceptibility according to standard disc diffusion method. By questionnaire survey 12 pharmacies using simulated...
Rapid nongenomic effects of thyroid hormones L-T(3) and L-T(4) on two plasma membrane transport systems were investigated in 14-d-old 19-d-old chick embryo hepatocytes. The Na(+)/H(+) exchanger activity was measured using the intracellular pH-sensitive fluorescent probe 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester, whereas amino acid estimated by [1-(14)C]-2-aminoisobutyric uptake. System A activation linear to hormone concentration, Na/H gave a bell-shaped...
In rats, various growth factors and hormones, as well partial hepatectomy (PH) are able to trigger the proliferative response of hepatocytes. Although recent evidence highlights important role thyroid hormones status in regulating liver cells vitro vivo models, mechanism involved pro-proliferative effects is still unclear. Here we have investigated how rats made hypo- hyperthyroid after prolonged treatment respectively with propylthiouracil (PTU) triiodothyronine (T3), affects regeneration...
Abstract The molecular mechanism by which thyroid hormones exert their effects on cell growth is still unknown. In this study, we used chick embryo hepatocytes at different stages of development as a model to investigate the effect two hormones, T3 and T4, metabolite T2, control proliferation. We observed that T2 provokes increase DNA‐synthesis well independently developmental stage. found stimulatory S phase reverted specific inhibitors protein kinase C (PKC) p42/44 mitogen‐activated...
The possible nuclear compartmentalization of glutathione S-transferase (GST) isoenzymes has been the subject contradictory reports. discovery that dinitrosyl-diglutathionyl-iron complex binds tightly to Alpha class GSTs in rat hepatocytes and a significant part bound is also associated with fraction (Pedersen, J. Z., De Maria, F., Turella, P., Federici, G., Mattei, M., Fabrini, R., Dawood, K. Massimi, Caccuri, A. Ricci, G. (2007) Biol. Chem. 282, 6364–6371) prompted us reconsider...
Retinoic acid (RA), the most biologically active metabolite of vitamin A, is known to modulate cell proliferation, apoptosis and differentiation, with different effects depending on cellular context. can exert its by directly or indirectly influencing expression genes involved in control proliferation. In present report we investigate possible correlation between antiproliferative, differentiative apoptotic previously observed rat hepatocytes HepG2 cells, a modulation cell-cycle regulators....
Nongenomic effects of thyroid hormones on Na + -K -ATPase activity were studied in chick embryo hepatocytes at two different developmental stages, 14 and 19 days embryonal age, the signal transduction pathways involved characterized. Our data showed following. 1) 3,5,3′-Triiodo-l-thyronine (T 3 ) 3,5-diiodo-l-thyronine (3,5-T 2 rapidly induced a transient inhibitory effect -ATPase; extent duration depended age cells. 2) 3,5-T behaved as true hormone fully mimicked T . 3) Thyroxine had no any...
The modulation by epidermal growth factor (EGF) of the Na+/H+ antiport in fetal and adult rat hepatocytes was studied nominally HCO3- free solution. EGF (10 nM) activated 0.22 +/- 0.03 (mean SD;n=10) pH units over basal value, measured with fluorescent pH-sensitive intracellular probe, 2',7'-bis(carboxyethyl)-5(6)- carboxyfluorescein (BCECF). effect inhibited amiloride analogue 5-(N-ethyl-N-isopropyl) (EIPA), ouabain, inhibitor Na+ pump, erbstatin analogue, an tyrosine kinase activity...
The regenerating liver presents a changed ability to use mevalonate 16 hr after partial hepatectomy. dolichol content and its synthesis from is increased, while no variation of dolichyl-P ubiquinone parameters are detectable. greater amount ofmevalonate utilized form dolichol, but not dolichyl-P, in this proliferating system, raises some questions about the physiological significance these isoprenoid compounds their biosynthetic sequence.